Silodosin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Silodosin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Silodosin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0426906
NUP58 nucleoporin 58 0.0420655
SNX14 sorting nexin 14 0.0412102
APLP2 amyloid beta (A4) precursor-like protein 2 0.038277
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0351434
SMAP1 small ArfGAP 1 0.0344754
HDGF hepatoma-derived growth factor 0.0309346
CHD1 chromodomain helicase DNA binding protein 1 0.0304171
ARFGEF3 ARFGEF family member 3 0.0302235
GOLGA2 golgin A2 0.0302134
PHF3 PHD finger protein 3 0.0295614
CDC42SE2 CDC42 small effector 2 0.02897
EEF1G eukaryotic translation elongation factor 1 gamma 0.028902
BIRC3 baculoviral IAP repeat containing 3 0.0288506
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0286273
SPAG9 sperm associated antigen 9 0.027766
CAMTA1 calmodulin binding transcription activator 1 0.0277247
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0268166
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0267487
BCLAF1 BCL2-associated transcription factor 1 0.0267139
RAB6A RAB6A, member RAS oncogene family 0.0265855
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0262588
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0257796
CUL3 cullin 3 0.0254636
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0251924
SET SET nuclear proto-oncogene 0.0249876
AGO2 argonaute RISC catalytic component 2 0.0249504
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0249425
CDK19 cyclin-dependent kinase 19 0.0249061
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0248398
FAM117B family with sequence similarity 117, member B 0.0246859
RNF145 ring finger protein 145 0.0244874
USP37 ubiquitin specific peptidase 37 0.023892
HMGB2 high mobility group box 2 0.0236764
RB1CC1 RB1-inducible coiled-coil 1 0.0234539
PCBP2 poly(rC) binding protein 2 0.0233927
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0230773
APOLD1 apolipoprotein L domain containing 1 0.0229568
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0228403
DGKD diacylglycerol kinase, delta 130kDa 0.0228204
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0228133
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0227659
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0225415
MAP2K1 mitogen-activated protein kinase kinase 1 0.0218122
UBQLN1 ubiquilin 1 0.0217822
TFG TRK-fused gene 0.0217221
SEPTIN2 septin 2 0.0216981
ATXN2 ataxin 2 0.0216871
RIMKLB ribosomal modification protein rimK-like family member B 0.0216796
CENPF centromere protein F, 350/400kDa 0.0216784
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0216497
MATR3 matrin 3 0.0216454
TPR translocated promoter region, nuclear basket protein 0.0215575
FNBP4 formin binding protein 4 0.0214888
ERBIN erbb2 interacting protein 0.0213573
ZC3H13 zinc finger CCCH-type containing 13 0.021319
RHEB Ras homolog enriched in brain 0.0212405
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.021191
ANLN anillin, actin binding protein 0.0211505
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207516
CLTC clathrin, heavy chain (Hc) 0.0206457
CKAP2 cytoskeleton associated protein 2 0.0203463
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0203341
WAC WW domain containing adaptor with coiled-coil 0.0200814
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0200317
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0200159
XPO1 exportin 1 0.0200042
TBK1 TANK-binding kinase 1 0.0198507
PEAK1 pseudopodium-enriched atypical kinase 1 0.0198461
TRA2B transformer 2 beta homolog (Drosophila) 0.0198094
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0197118
SRPK1 SRSF protein kinase 1 0.0195789
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0195061
TWSG1 twisted gastrulation BMP signaling modulator 1 0.0194301
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0193595
PTBP2 polypyrimidine tract binding protein 2 0.0192675
TBC1D5 TBC1 domain family, member 5 0.019219
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0192014
RACGAP1 Rac GTPase activating protein 1 0.0191846
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0190309
CCNB1 cyclin B1 0.0189242
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0188721
MSN moesin 0.0188012
TOP2B topoisomerase (DNA) II beta 180kDa 0.0185993
TXNRD1 thioredoxin reductase 1 0.0185574
PRRC1 proline-rich coiled-coil 1 0.0184698
DPY19L1 dpy-19-like 1 (C. elegans) 0.0183765
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.018251
GSPT1 G1 to S phase transition 1 0.018216
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.017997
SRSF11 serine/arginine-rich splicing factor 11 0.0178029
JMJD1C jumonji domain containing 1C 0.0176294
CALU calumenin 0.0176146
ARHGAP21 Rho GTPase activating protein 21 0.0175285
SEC13 SEC13 homolog (S. cerevisiae) 0.0173993
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.017385
ARL15 ADP-ribosylation factor-like 15 0.0173434
NDC80 NDC80 kinetochore complex component 0.0173182
FBXO11 F-box protein 11 0.0171261
ANAPC10 anaphase promoting complex subunit 10 0.0171168

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.475967
VIM vimentin -0.187092
TMSB10 thymosin beta 10 -0.0970647
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.092317
IGFBP3 insulin-like growth factor binding protein 3 -0.0798525
FNDC3B fibronectin type III domain containing 3B -0.0689617
PKM pyruvate kinase, muscle -0.0644155
CD44 CD44 molecule (Indian blood group) -0.0643271
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0622924
LOC112694756 uncharaterized LOC112694756 -0.0549078
TPT1 tumor protein, translationally-controlled 1 -0.0533929
RPLP1 ribosomal protein, large, P1 -0.050471
SAMD4A sterile alpha motif domain containing 4A -0.0499125
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0488926
ELL2 elongation factor, RNA polymerase II, 2 -0.047422
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0466272
MT2A metallothionein 2A -0.0457143
HMGA2 high mobility group AT-hook 2 -0.0449273
OSMR oncostatin M receptor -0.0448572
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0446889
ACTG1 actin gamma 1 -0.0445876
AKAP12 A kinase (PRKA) anchor protein 12 -0.0417637
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0414572
RPS25 ribosomal protein S25 -0.0400261
RPL23 ribosomal protein L23 -0.0390388
ATM ATM serine/threonine kinase -0.0387028
THSD4 thrombospondin, type I, domain containing 4 -0.038281
AHNAK AHNAK nucleoprotein -0.038002
SLC38A2 solute carrier family 38, member 2 -0.0377235
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0367203
ANXA2 annexin A2 -0.0362192
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0352965
RPL35A ribosomal protein L35a -0.0352152
PTMA prothymosin, alpha -0.0338038
TM4SF1 transmembrane 4 L six family member 1 -0.0336591
RPS8 ribosomal protein S8 -0.0331745
RPS6 ribosomal protein S6 -0.033164
FTH1 ferritin, heavy polypeptide 1 -0.0330987
BIRC6 baculoviral IAP repeat containing 6 -0.0327835
GNAS GNAS complex locus -0.0327481
DST dystonin -0.0327403
IER3 immediate early response 3 -0.0321795
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0321669
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0318631
BASP1 brain abundant, membrane attached signal protein 1 -0.0317809
RORA RAR-related orphan receptor A -0.031705
RNF213 ring finger protein 213 -0.0316123
DOCK4 dedicator of cytokinesis 4 -0.0308722
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.030866
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0308209
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0307836
PHF14 PHD finger protein 14 -0.030477
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.030393
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0303027
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0300257
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0299837
FUS FUS RNA binding protein -0.0296089
SH3KBP1 SH3-domain kinase binding protein 1 -0.029527
BPTF bromodomain PHD finger transcription factor -0.0295172
EXT1 exostosin glycosyltransferase 1 -0.0293911
LDHA lactate dehydrogenase A -0.0293115
UBE2H ubiquitin-conjugating enzyme E2H -0.0292751
AK1 adenylate kinase 1 -0.0291194
ZBTB38 zinc finger and BTB domain containing 38 -0.0289033
EEF2 eukaryotic translation elongation factor 2 -0.0288868
TPM4 tropomyosin 4 -0.0287415
TRIP12 thyroid hormone receptor interactor 12 -0.0286679
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0285695
HDAC9 histone deacetylase 9 -0.0285172
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284201
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0281527
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.028093
ZBTB20 zinc finger and BTB domain containing 20 -0.0278624
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.027861
RPLP2 ribosomal protein, large, P2 -0.0278182
ANGPTL4 angiopoietin-like 4 -0.0277344
VCL vinculin -0.0277214
MBNL1 muscleblind-like splicing regulator 1 -0.0274732
HIPK2 homeodomain interacting protein kinase 2 -0.0273691
NAV3 neuron navigator 3 -0.0272152
SMYD3 SET and MYND domain containing 3 -0.0269801
DENND5B DENN/MADD domain containing 5B -0.0269035
FRMD6 FERM domain containing 6 -0.02689
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0267221
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.026692
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0263387
UBB ubiquitin B -0.0261315
WWTR1 WW domain containing transcription regulator 1 -0.0261228
BCAS3 breast carcinoma amplified sequence 3 -0.0260523
INTS6 integrator complex subunit 6 -0.0253074
NDRG1 N-myc downstream regulated 1 -0.0250725
SCAPER S-phase cyclin A-associated protein in the ER -0.0250411
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0248399
ENO2 enolase 2 (gamma, neuronal) -0.0247965
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0247833
RAI14 retinoic acid induced 14 -0.0247707
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0246853
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0244398
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0244015
NUMB numb homolog (Drosophila) -0.0242971