| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.219241 |
| FBN1 | fibrillin 1 | 0.21543 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.185948 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.125321 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.115644 |
| MT2A | metallothionein 2A | 0.0885998 |
| COL1A2 | collagen, type I, alpha 2 | 0.0802209 |
| MYOF | myoferlin | 0.07518 |
| ATP13A3 | ATPase type 13A3 | 0.0727543 |
| CD44 | CD44 molecule (Indian blood group) | 0.0718748 |
| GPC6 | glypican 6 | 0.0684204 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0658858 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0657197 |
| FNDC3B | fibronectin type III domain containing 3B | 0.063688 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.063353 |
| PRELID2 | PRELI domain containing 2 | 0.0603214 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0554215 |
| DST | dystonin | 0.0551956 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0545524 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.052721 |
| LOXL2 | lysyl oxidase-like 2 | 0.0502121 |
| B2M | beta-2-microglobulin | 0.0499754 |
| RUNX1 | runt-related transcription factor 1 | 0.0490734 |
| PLAT | plasminogen activator, tissue | 0.0490565 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0486768 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0461295 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0452188 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0441843 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0408374 |
| FLNB | filamin B, beta | 0.0401957 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0400417 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0385248 |
| GLIS3 | GLIS family zinc finger 3 | 0.0372591 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0367745 |
| YEATS2 | YEATS domain containing 2 | 0.0360287 |
| STC1 | stanniocalcin 1 | 0.03596 |
| SVIL | supervillin | 0.0356788 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0353125 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0349326 |
| LDHA | lactate dehydrogenase A | 0.0342448 |
| NEK7 | NIMA-related kinase 7 | 0.034055 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0329904 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0321237 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0309941 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0304523 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.030131 |
| CD109 | CD109 molecule | 0.029825 |
| KIFAP3 | kinesin-associated protein 3 | 0.0297505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.029491 |
| PKM | pyruvate kinase, muscle | 0.0288715 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0288351 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0287051 |
| CTSB | cathepsin B | 0.0286002 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0284266 |
| SP3 | Sp3 transcription factor | 0.0283071 |
| FNIP1 | folliculin interacting protein 1 | 0.0280117 |
| ANKRD36 | ankyrin repeat domain 36 | 0.027808 |
| NAV1 | neuron navigator 1 | 0.0275089 |
| ARRDC3 | arrestin domain containing 3 | 0.0273644 |
| AUTS2 | autism susceptibility candidate 2 | 0.0272708 |
| HDAC9 | histone deacetylase 9 | 0.0269211 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0265343 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0263303 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0259584 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0258753 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0256968 |
| MEF2A | myocyte enhancer factor 2A | 0.0254702 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0254012 |
| SEPTIN9 | septin 9 | 0.0249555 |
| ZNF292 | zinc finger protein 292 | 0.0249266 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0248204 |
| PGK1 | phosphoglycerate kinase 1 | 0.0246083 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0241909 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0240765 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0240212 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0238971 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.023874 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0238089 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0238024 |
| C5ORF15 | chromosome 5 open reading frame 15 | 0.0237742 |
| COL3A1 | collagen, type III, alpha 1 | 0.0234197 |
| NOTCH2 | notch 2 | 0.0233215 |
| CLU | clusterin | 0.0233107 |
| SBF2 | SET binding factor 2 | 0.0232085 |
| PRKD3 | protein kinase D3 | 0.0230203 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0228541 |
| SYTL3 | synaptotagmin-like 3 | 0.0227801 |
| TENM3 | teneurin transmembrane protein 3 | 0.0227064 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0227002 |
| FADS2 | fatty acid desaturase 2 | 0.0226024 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0225406 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0224897 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0223451 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0221201 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.022117 |
| TDRD7 | tudor domain containing 7 | 0.0219478 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0219043 |
| COL5A2 | collagen, type V, alpha 2 | 0.0217575 |
| KIAA1217 | KIAA1217 | 0.0217053 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0216864 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.21071 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.146092 |
| VIM | vimentin | -0.144775 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.119692 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0879144 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0873357 |
| FN1 | fibronectin 1 | -0.061262 |
| MAP1B | microtubule-associated protein 1B | -0.0564172 |
| CALR | calreticulin | -0.0539418 |
| NDRG1 | N-myc downstream regulated 1 | -0.0528034 |
| PTMA | prothymosin, alpha | -0.0502373 |
| AHNAK | AHNAK nucleoprotein | -0.0496804 |
| CANX | calnexin | -0.0477041 |
| TPM4 | tropomyosin 4 | -0.0427381 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0424388 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0409044 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0388877 |
| S100A10 | S100 calcium binding protein A10 | -0.0369093 |
| EGFR | epidermal growth factor receptor | -0.0358059 |
| COL5A1 | collagen, type V, alpha 1 | -0.0349981 |
| CSTB | cystatin B (stefin B) | -0.0343346 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0338529 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0330041 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0289518 |
| FBXO11 | F-box protein 11 | -0.0267423 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0260464 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0257658 |
| COPA | coatomer protein complex, subunit alpha | -0.0247934 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0244317 |
| HDLBP | high density lipoprotein binding protein | -0.0240076 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0238105 |
| JUN | jun proto-oncogene | -0.0236519 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0233398 |
| RRBP1 | ribosome binding protein 1 | -0.0232949 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0232698 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0232145 |
| LMNA | lamin A/C | -0.0231992 |
| TMSB10 | thymosin beta 10 | -0.0229201 |
| VEGFA | vascular endothelial growth factor A | -0.0229193 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0229148 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0226075 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0225662 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0223513 |
| GOLGB1 | golgin B1 | -0.0222268 |
| CDH13 | cadherin 13 | -0.0218972 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0217589 |
| VMP1 | vacuole membrane protein 1 | -0.0211856 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0206043 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0205837 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0203348 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0200739 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0198306 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0197573 |
| MTDH | metadherin | -0.0196258 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0195171 |
| FAM107B | family with sequence similarity 107, member B | -0.0188232 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0187448 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0179513 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0178775 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0178502 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0177491 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0175924 |
| EGR1 | early growth response 1 | -0.0175593 |
| DSPP | dentin sialophosphoprotein | -0.0175213 |
| SEC24D | SEC24 family member D | -0.0170021 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.016845 |
| POTEF | POTE ankyrin domain family, member F | -0.016633 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0166273 |
| INSIG1 | insulin induced gene 1 | -0.0165514 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0165236 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0164993 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0164196 |
| FTL | ferritin, light polypeptide | -0.0163793 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0162146 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0162028 |
| TGFB1 | transforming growth factor, beta 1 | -0.0160743 |
| CENPF | centromere protein F, 350/400kDa | -0.0160441 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0160044 |
| RPS24 | ribosomal protein S24 | -0.0156917 |
| CTSD | cathepsin D | -0.0156813 |
| GDF15 | growth differentiation factor 15 | -0.0156046 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0156018 |
| TAOK1 | TAO kinase 1 | -0.0155872 |
| ASPH | aspartate beta-hydroxylase | -0.0155739 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.01556 |
| CDK13 | cyclin-dependent kinase 13 | -0.0155449 |
| SH3GL1 | SH3-domain GRB2-like 1 | -0.0153107 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0151133 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0150943 |
| RAB5A | RAB5A, member RAS oncogene family | -0.014944 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0147891 |
| PFN1 | profilin 1 | -0.0147773 |
| FOSL1 | FOS-like antigen 1 | -0.0145231 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0144642 |
| FSTL1 | follistatin-like 1 | -0.014322 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0142945 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0142502 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | -0.0142053 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0141046 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | -0.0140605 |
