| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.154562 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.13143 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.125423 |
| NLGN1 | neuroligin 1 | 0.112342 |
| DST | dystonin | 0.106948 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.103335 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0991113 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0955477 |
| TENM3 | teneurin transmembrane protein 3 | 0.088255 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0879614 |
| TXNRD1 | thioredoxin reductase 1 | 0.0871418 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0828599 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0771395 |
| TMEM41B | transmembrane protein 41B | 0.0771154 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0750217 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0744112 |
| VIM | vimentin | 0.0736826 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0729875 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.066581 |
| NEK7 | NIMA-related kinase 7 | 0.065101 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0649363 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0632218 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0604943 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0601345 |
| PGK1 | phosphoglycerate kinase 1 | 0.0584875 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0579447 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0570162 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0566484 |
| PUM2 | pumilio RNA-binding family member 2 | 0.05649 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.05618 |
| SMYD3 | SET and MYND domain containing 3 | 0.0543087 |
| EPHA6 | EPH receptor A6 | 0.0534765 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0523187 |
| ZNF292 | zinc finger protein 292 | 0.0519455 |
| PCBP2 | poly(rC) binding protein 2 | 0.0506915 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0505286 |
| MMP12 | matrix metallopeptidase 12 | 0.0494111 |
| ANXA1 | annexin A1 | 0.0492654 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0490138 |
| KIF5B | kinesin family member 5B | 0.0486731 |
| LDHA | lactate dehydrogenase A | 0.0485173 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0480282 |
| DTNA | dystrobrevin, alpha | 0.0479991 |
| USP34 | ubiquitin specific peptidase 34 | 0.047762 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0475423 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0474812 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0468613 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0440009 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0437887 |
| YEATS2 | YEATS domain containing 2 | 0.0431585 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0430275 |
| NEBL | nebulette | 0.0429561 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.042665 |
| TPR | translocated promoter region, nuclear basket protein | 0.04035 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.039414 |
| RAD51B | RAD51 paralog B | 0.0389285 |
| EHBP1 | EH domain binding protein 1 | 0.0387246 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0378074 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0375737 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0373807 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0366824 |
| CPOX | coproporphyrinogen oxidase | 0.0366042 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0365212 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0361137 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0359825 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0358811 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0353834 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0347612 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0345347 |
| LMO7 | LIM domain 7 | 0.034462 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.034308 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.034289 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.034278 |
| ECT2 | epithelial cell transforming 2 | 0.0337436 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0336352 |
| RPLP0 | ribosomal protein, large, P0 | 0.0332628 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.032947 |
| ATP11A | ATPase, class VI, type 11A | 0.0328335 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0327401 |
| TNPO1 | transportin 1 | 0.0324187 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0322133 |
| KIAA1328 | KIAA1328 | 0.0316878 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.031659 |
| EPHA5 | EPH receptor A5 | 0.0315848 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0315813 |
| CEP192 | centrosomal protein 192kDa | 0.0315297 |
| NF1 | neurofibromin 1 | 0.0315161 |
| EXOC6B | exocyst complex component 6B | 0.0312167 |
| IL6ST | interleukin 6 signal transducer | 0.0311982 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.03118 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0310702 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0310086 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0309193 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0309028 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0308454 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0308365 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0308332 |
| TMEM123 | transmembrane protein 123 | 0.0305886 |
| PREPL | prolyl endopeptidase-like | 0.0305674 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0303515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.100827 |
| TMSB10 | thymosin beta 10 | -0.0915769 |
| PTMA | prothymosin, alpha | -0.0832708 |
| HMGA2 | high mobility group AT-hook 2 | -0.0770934 |
| CALR | calreticulin | -0.0464442 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0386742 |
| FTL | ferritin, light polypeptide | -0.0362836 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0334296 |
| ASPH | aspartate beta-hydroxylase | -0.0331705 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0320842 |
| INTS6 | integrator complex subunit 6 | -0.0310864 |
| EGR1 | early growth response 1 | -0.0290533 |
| RPL35A | ribosomal protein L35a | -0.0287032 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0283717 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0269917 |
| ZNF804A | zinc finger protein 804A | -0.0256869 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0255038 |
| TBCA | tubulin folding cofactor A | -0.0250328 |
| LRRC23 | leucine rich repeat containing 23 | -0.0237072 |
| ACTG1 | actin gamma 1 | -0.0235075 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0234477 |
| HMGB1 | high mobility group box 1 | -0.0233361 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0225351 |
| GNAS | GNAS complex locus | -0.0215531 |
| S100A10 | S100 calcium binding protein A10 | -0.0212631 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0207431 |
| ADIPOR2 | adiponectin receptor 2 | -0.0204274 |
| RPS19 | ribosomal protein S19 | -0.0192405 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0189998 |
| YBX3 | Y box binding protein 3 | -0.0187555 |
| RPS25 | ribosomal protein S25 | -0.0178011 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0172106 |
| CUX1 | cut-like homeobox 1 | -0.0171965 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0168645 |
| GCG | glucagon | -0.01646 |
| MYPN | myopalladin | -0.0164222 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -0.0163576 |
| YBX1 | Y box binding protein 1 | -0.0158564 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.015826 |
| KHSRP | KH-type splicing regulatory protein | -0.015767 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0157096 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0155771 |
| RSU1 | Ras suppressor protein 1 | -0.015489 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.015386 |
| RPL34 | ribosomal protein L34 | -0.0152275 |
| NAV3 | neuron navigator 3 | -0.0151115 |
| ADD2 | adducin 2 (beta) | -0.0150787 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0145714 |
| NHSL1 | NHS-like 1 | -0.014394 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.014302 |
| RPLP2 | ribosomal protein, large, P2 | -0.0142471 |
| TCF20 | transcription factor 20 (AR1) | -0.0139327 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0138697 |
| RPS23 | ribosomal protein S23 | -0.0138302 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0138123 |
| MAP4 | microtubule-associated protein 4 | -0.0137702 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | -0.0136926 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0135853 |
| TUBA1B | tubulin, alpha 1b | -0.0131863 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0131433 |
| RPL36 | ribosomal protein L36 | -0.0131113 |
| JUN | jun proto-oncogene | -0.0129832 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0129385 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0127989 |
| PDCD6 | programmed cell death 6 | -0.0127865 |
| CALD1 | caldesmon 1 | -0.0126073 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0124072 |
| RPS24 | ribosomal protein S24 | -0.012308 |
| HMGA1 | high mobility group AT-hook 1 | -0.0122668 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0121554 |
| CFAP70 | cilia and flagella associated protein 70 | -0.0121531 |
| TGM2 | transglutaminase 2 | -0.012087 |
| DGKH | diacylglycerol kinase, eta | -0.0118627 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0117993 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0116285 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.011541 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0115073 |
| FASN | fatty acid synthase | -0.0114854 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0114351 |
| TCF12 | transcription factor 12 | -0.0114217 |
| MYOM1 | myomesin 1 | -0.0114074 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0113927 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0113821 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0113128 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0112262 |
| MEF2D | myocyte enhancer factor 2D | -0.0111263 |
| RBM10 | RNA binding motif protein 10 | -0.011072 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0110542 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0109832 |
| NOP56 | NOP56 ribonucleoprotein | -0.0109662 |
| RPL27 | ribosomal protein L27 | -0.0109469 |
| FRMD5 | FERM domain containing 5 | -0.0105917 |
| SMIM44 | small integral membrane protein 44 | -0.0105823 |
| TMEM181 | transmembrane protein 181 | -0.0105653 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0105374 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0105319 |
| FKBP2 | FK506 binding protein 2, 13kDa | -0.0103297 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.010294 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0102119 |
| ANKRD28 | ankyrin repeat domain 28 | -0.010165 |
