| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.23763 |
| FAM13A | family with sequence similarity 13, member A | 0.0980819 |
| MEIS2 | Meis homeobox 2 | 0.0732497 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.064398 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0561997 |
| HELZ | helicase with zinc finger | 0.0556665 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0514763 |
| ZNF292 | zinc finger protein 292 | 0.0503029 |
| FNBP1 | formin binding protein 1 | 0.0463849 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0444691 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0430977 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0411156 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0392342 |
| MEF2A | myocyte enhancer factor 2A | 0.0389669 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0379895 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0378652 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0374129 |
| MAP1B | microtubule-associated protein 1B | 0.0373053 |
| PKM | pyruvate kinase, muscle | 0.036574 |
| OGA | O-GlcNAcase | 0.0356602 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0355828 |
| WDR45B | WD repeat domain 45B | 0.0352329 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0346546 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0338664 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.033262 |
| DTNA | dystrobrevin, alpha | 0.0323305 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0321058 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0313023 |
| PCBP2 | poly(rC) binding protein 2 | 0.030264 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0301039 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0295955 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0292031 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0289897 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0279409 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0277277 |
| LPIN1 | lipin 1 | 0.0274692 |
| RNF145 | ring finger protein 145 | 0.0265339 |
| USP3 | ubiquitin specific peptidase 3 | 0.0264345 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0263479 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0258338 |
| SETD5 | SET domain containing 5 | 0.0255372 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0253052 |
| INSIG2 | insulin induced gene 2 | 0.0252587 |
| ZNF148 | zinc finger protein 148 | 0.0251098 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0247756 |
| NUP58 | nucleoporin 58 | 0.0244823 |
| RFX7 | regulatory factor X, 7 | 0.0242599 |
| NBAS | neuroblastoma amplified sequence | 0.0239482 |
| DENND4C | DENN/MADD domain containing 4C | 0.023704 |
| RARA | retinoic acid receptor, alpha | 0.0235112 |
| NDRG1 | N-myc downstream regulated 1 | 0.0235089 |
| NEK7 | NIMA-related kinase 7 | 0.0234336 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0232304 |
| PTEN | phosphatase and tensin homolog | 0.0231812 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0229326 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0229012 |
| XPO1 | exportin 1 | 0.022809 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0226728 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0226195 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0225808 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0224842 |
| SBF2 | SET binding factor 2 | 0.0223723 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.022314 |
| RNF150 | ring finger protein 150 | 0.0221008 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0220851 |
| PDE8A | phosphodiesterase 8A | 0.02181 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0215855 |
| YTHDC1 | YTH domain containing 1 | 0.0214316 |
| PGK1 | phosphoglycerate kinase 1 | 0.0213323 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0211919 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0210471 |
| ECT2 | epithelial cell transforming 2 | 0.0210386 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0209462 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0209219 |
| CENPF | centromere protein F, 350/400kDa | 0.0205677 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0203938 |
| GOLGA4 | golgin A4 | 0.0203438 |
| TOB1 | transducer of ERBB2, 1 | 0.0200859 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0200359 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0199624 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0198831 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0198083 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0197667 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0197613 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0195575 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0193696 |
| SUCO | SUN domain containing ossification factor | 0.0193087 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0192721 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0192348 |
| ARRDC3 | arrestin domain containing 3 | 0.0191598 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0190218 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.018949 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0189372 |
| FOXO3 | forkhead box O3 | 0.0188419 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0188047 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0186617 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0185353 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0184763 |
| CDC27 | cell division cycle 27 | 0.0181596 |
| RAB21 | RAB21, member RAS oncogene family | 0.0179341 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.284933 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.202307 |
| LSAMP | limbic system-associated membrane protein | -0.191532 |
| VCL | vinculin | -0.16836 |
| EXT1 | exostosin glycosyltransferase 1 | -0.13167 |
| PRKCA | protein kinase C, alpha | -0.125738 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.102538 |
| IGF2 | insulin-like growth factor 2 | -0.0979229 |
| ACTG1 | actin gamma 1 | -0.0941234 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0886156 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0806587 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0758281 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0678515 |
| CUX1 | cut-like homeobox 1 | -0.0676405 |
| ZNF804A | zinc finger protein 804A | -0.0659125 |
| PLAT | plasminogen activator, tissue | -0.0654796 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0640989 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0634679 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0621205 |
| PTMA | prothymosin, alpha | -0.0620695 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0619995 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0605262 |
| TPM1 | tropomyosin 1 (alpha) | -0.0567841 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0560616 |
| TPM4 | tropomyosin 4 | -0.0560427 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0560371 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0542176 |
| EGR1 | early growth response 1 | -0.0534049 |
| MSI2 | musashi RNA-binding protein 2 | -0.053041 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0529049 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0522515 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0518465 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0515911 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0511547 |
| SYT1 | synaptotagmin I | -0.0511357 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0509676 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0487246 |
| FRMD4A | FERM domain containing 4A | -0.0484704 |
| BPTF | bromodomain PHD finger transcription factor | -0.0484376 |
| VMP1 | vacuole membrane protein 1 | -0.0481661 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.047744 |
| NREP | neuronal regeneration related protein | -0.0472114 |
| NPAS2 | neuronal PAS domain protein 2 | -0.047187 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0444772 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0439981 |
| COL1A1 | collagen, type I, alpha 1 | -0.0433522 |
| CDH13 | cadherin 13 | -0.0431866 |
| CRH | corticotropin releasing hormone | -0.0430906 |
| MCL1 | myeloid cell leukemia 1 | -0.043022 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0429783 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0428475 |
| CADM2 | cell adhesion molecule 2 | -0.0418423 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0417395 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0400583 |
| RPL35A | ribosomal protein L35a | -0.0393427 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0393412 |
| CNTN4 | contactin 4 | -0.0392786 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0385629 |
| EFNA5 | ephrin-A5 | -0.0384257 |
| KLHL13 | kelch-like family member 13 | -0.0374761 |
| CCDC57 | coiled-coil domain containing 57 | -0.0357738 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0355746 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0352626 |
| RPL23 | ribosomal protein L23 | -0.0347069 |
| DNM3 | dynamin 3 | -0.0346414 |
| IER3 | immediate early response 3 | -0.0345673 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0339482 |
| TCF12 | transcription factor 12 | -0.0338482 |
| SP100 | SP100 nuclear antigen | -0.0336985 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0333799 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0332607 |
| RPS24 | ribosomal protein S24 | -0.0330102 |
| RNF213 | ring finger protein 213 | -0.0324981 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0324327 |
| PARD3 | par-3 family cell polarity regulator | -0.0322048 |
| RPLP1 | ribosomal protein, large, P1 | -0.0320475 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0318947 |
| VIM | vimentin | -0.0318319 |
| EGFR | epidermal growth factor receptor | -0.031798 |
| HMGA2 | high mobility group AT-hook 2 | -0.0316982 |
| TRIM24 | tripartite motif containing 24 | -0.0312685 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0306413 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0305901 |
| HIP1 | huntingtin interacting protein 1 | -0.0302022 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0302012 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0299432 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0297497 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0297478 |
| MYO1E | myosin IE | -0.0296927 |
| FMN1 | formin 1 | -0.0294812 |
| COL3A1 | collagen, type III, alpha 1 | -0.0294349 |
| RPS12 | ribosomal protein S12 | -0.0290911 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0290672 |
| GSE1 | Gse1 coiled-coil protein | -0.028964 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0283462 |
| SMYD3 | SET and MYND domain containing 3 | -0.0281912 |
| SIK2 | salt-inducible kinase 2 | -0.0281707 |
| CALD1 | caldesmon 1 | -0.0276336 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0275867 |
| UBAP2 | ubiquitin associated protein 2 | -0.0275179 |
