Simotinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Simotinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Simotinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.116561
EGLN3 egl-9 family hypoxia-inducible factor 3 0.112318
RUNX1 runt-related transcription factor 1 0.090094
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0895242
ASPH aspartate beta-hydroxylase 0.0879775
PGK1 phosphoglycerate kinase 1 0.0829782
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0819174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0760893
PHF3 PHD finger protein 3 0.0747947
ZMYND8 zinc finger, MYND-type containing 8 0.0725464
PRELID2 PRELI domain containing 2 0.0717548
ARHGAP26 Rho GTPase activating protein 26 0.0688279
STK39 serine threonine kinase 39 0.0686155
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0657447
RAD51B RAD51 paralog B 0.0617243
MEIS2 Meis homeobox 2 0.0605059
IFNGR1 interferon gamma receptor 1 0.0589689
NRIP1 nuclear receptor interacting protein 1 0.0579303
LPP LIM domain containing preferred translocation partner in lipoma 0.0551533
TRIO trio Rho guanine nucleotide exchange factor 0.0544232
SORBS1 sorbin and SH3 domain containing 1 0.0534258
ZBTB20 zinc finger and BTB domain containing 20 0.0531261
RNF43 ring finger protein 43 0.052204
UBAC2 UBA domain containing 2 0.0521911
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0519179
ZMYM2 zinc finger, MYM-type 2 0.0516369
STS steroid sulfatase (microsomal), isozyme S 0.0506622
PRKCA protein kinase C, alpha 0.0502401
SAMD12 sterile alpha motif domain containing 12 0.0494587
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0481701
PTGR1 prostaglandin reductase 1 0.0469708
GCLC glutamate-cysteine ligase, catalytic subunit 0.0465964
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0465202
FAT1 FAT atypical cadherin 1 0.0460463
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0458151
NCKAP5 NCK-associated protein 5 0.0450583
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0449567
DENND4C DENN/MADD domain containing 4C 0.0446729
FNDC3B fibronectin type III domain containing 3B 0.0444468
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.044332
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0438799
GMDS GDP-mannose 4,6-dehydratase 0.0431454
ZDHHC20 zinc finger, DHHC-type containing 20 0.0431392
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0418561
MSI2 musashi RNA-binding protein 2 0.0399353
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0395538
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0395328
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0394395
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0391745
PDIA3 protein disulfide isomerase family A, member 3 0.0389348
ABHD2 abhydrolase domain containing 2 0.0388435
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0382662
SMYD3 SET and MYND domain containing 3 0.037858
PTK2 protein tyrosine kinase 2 0.0369127
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.036766
BICRAL BICRA like chromatin remodeling complex associated protein 0.0360815
TXNRD1 thioredoxin reductase 1 0.0359549
WWOX WW domain containing oxidoreductase 0.0359311
TXNIP thioredoxin interacting protein 0.035679
ARHGAP32 Rho GTPase activating protein 32 0.0356456
RHOBTB3 Rho-related BTB domain containing 3 0.0355361
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0353225
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0350234
ERRFI1 ERBB receptor feedback inhibitor 1 0.0349995
CCDC146 coiled-coil domain containing 146 0.034419
EHF ets homologous factor 0.0339309
KIF16B kinesin family member 16B 0.0337719
ARGLU1 arginine and glutamate rich 1 0.0337192
ARHGAP12 Rho GTPase activating protein 12 0.0337077
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0335429
SBF2 SET binding factor 2 0.0329021
KLF5 Kruppel-like factor 5 (intestinal) 0.032677
RNF149 ring finger protein 149 0.0324398
KMT2C lysine (K)-specific methyltransferase 2C 0.0324156
EHBP1 EH domain binding protein 1 0.0318491
PIAS1 protein inhibitor of activated STAT, 1 0.0318106
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0317299
PATJ PATJ crumbs cell polarity complex component 0.0315585
MYO10 myosin X 0.0315379
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0314096
LDHA lactate dehydrogenase A 0.0313605
PTEN phosphatase and tensin homolog 0.0304484
SPIDR scaffolding protein involved in DNA repair 0.0303001
ENO1 enolase 1, (alpha) 0.0301729
MEF2A myocyte enhancer factor 2A 0.0293878
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0292372
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0290963
ATXN1 ataxin 1 0.0289085
TAS2R14 taste receptor, type 2, member 14 0.028728
FMN1 formin 1 0.0287046
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0286386
KLF3 Kruppel-like factor 3 (basic) 0.0285477
AOPEP aminopeptidase O (putative) 0.0284796
ALPK1 alpha-kinase 1 0.0283609
ABLIM1 actin binding LIM protein 1 0.0283179
NDFIP2 Nedd4 family interacting protein 2 0.0282577
PTBP3 polypyrimidine tract binding protein 3 0.0282497
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.027947
IGF1R insulin-like growth factor 1 receptor 0.0278683
TBPL1 TBP-like 1 0.0277411

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.153261
ANXA2 annexin A2 -0.0739203
LMO7 LIM domain 7 -0.0735612
RAB7A RAB7A, member RAS oncogene family -0.0718943
INTS6 integrator complex subunit 6 -0.0707582
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0672736
EZR ezrin -0.0619922
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0567667
SQSTM1 sequestosome 1 -0.0526394
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0523915
MYO1E myosin IE -0.0417265
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0407958
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0406622
FTH1 ferritin, heavy polypeptide 1 -0.0400141
AREG amphiregulin -0.0399991
MCTP1 multiple C2 domains, transmembrane 1 -0.0387994
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0368307
JUN jun proto-oncogene -0.0367903
LYZ lysozyme -0.0365427
BLZF1 basic leucine zipper nuclear factor 1 -0.0352301
VMP1 vacuole membrane protein 1 -0.0350147
MORF4L2 mortality factor 4 like 2 -0.0346241
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0343913
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0330979
HM13 histocompatibility (minor) 13 -0.0330132
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0316968
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0316878
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0309073
CCNL1 cyclin L1 -0.030624
DDIT3 DNA-damage-inducible transcript 3 -0.029765
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0293862
HLA-B major histocompatibility complex, class I, B -0.0292885
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0292261
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0285754
SMAD3 SMAD family member 3 -0.0283139
MCL1 myeloid cell leukemia 1 -0.0280579
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0280454
LDLR low density lipoprotein receptor -0.0278441
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0278362
TMSB10 thymosin beta 10 -0.0276425
LOC102724023 ES1 protein homolog, mitochondrial -0.0274227
FTL ferritin, light polypeptide -0.0272654
UBAP2 ubiquitin associated protein 2 -0.0264009
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0263511
C6ORF132 chromosome 6 open reading frame 132 -0.0259471
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0258262
RPL35A ribosomal protein L35a -0.0249181
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0248282
MT2A metallothionein 2A -0.0247415
GOSR2 golgi SNAP receptor complex member 2 -0.0246911
NABP1 nucleic acid binding protein 1 -0.0239577
ACTG1 actin gamma 1 -0.0236751
RIGI RNA sensor RIG-I -0.0236236
LCN2 lipocalin 2 -0.0235939
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0232783
CLDN4 claudin 4 -0.0228118
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0227191
TNS4 tensin 4 -0.0223611
GDI2 GDP dissociation inhibitor 2 -0.0222473
COPA coatomer protein complex, subunit alpha -0.0221689
SPAG9 sperm associated antigen 9 -0.0221302
RPL19 ribosomal protein L19 -0.0215244
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0212539
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0212368
SEC31A SEC31 homolog A (S. cerevisiae) -0.0211202
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0209648
TJP1 tight junction protein 1 -0.0209485
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0206295
SP100 SP100 nuclear antigen -0.0205666
TSC22D2 TSC22 domain family, member 2 -0.0201909
MX2 MX dynamin-like GTPase 2 -0.0201463
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0201103
RPL23 ribosomal protein L23 -0.0200671
SEC24A SEC24 family member A -0.0200612
ATF4 activating transcription factor 4 -0.0200484
BRD2 bromodomain containing 2 -0.0198701
WSB1 WD repeat and SOCS box containing 1 -0.0198642
UGDH UDP-glucose 6-dehydrogenase -0.0195844
FOSL1 FOS-like antigen 1 -0.0190157
S100A10 S100 calcium binding protein A10 -0.0189863
RPL7L1 ribosomal protein L7-like 1 -0.0189236
RPS19 ribosomal protein S19 -0.0188581
FBXO39 F-box protein 39 -0.0187032
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0185688
IER2 immediate early response 2 -0.0184931
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0183218
STX5 syntaxin 5 -0.0179643
TUT7 terminal uridylyl transferase 7 -0.0179639
POF1B premature ovarian failure, 1B -0.0178841
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0177635
WASF2 WAS protein family, member 2 -0.0173948
IGFBP3 insulin-like growth factor binding protein 3 -0.0173673
OCLN occludin -0.0171674
PERP PERP, TP53 apoptosis effector -0.0171273
NFX1 nuclear transcription factor, X-box binding 1 -0.0171022
KYNU kynureninase -0.0170329
ARF4 ADP-ribosylation factor 4 -0.016928
TRIB1 tribbles pseudokinase 1 -0.0169249
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0168291
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0167101