| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.138915 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.135514 |
| COL6A3 | collagen, type VI, alpha 3 | 0.114265 |
| FNDC3B | fibronectin type III domain containing 3B | 0.112775 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.10634 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.104235 |
| CD44 | CD44 molecule (Indian blood group) | 0.0980603 |
| FN1 | fibronectin 1 | 0.0977756 |
| FBN1 | fibrillin 1 | 0.0947332 |
| LDHA | lactate dehydrogenase A | 0.0917291 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0915629 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0845744 |
| PRELID2 | PRELI domain containing 2 | 0.0839926 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.081895 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0792661 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0737318 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0713138 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0666885 |
| PDE10A | phosphodiesterase 10A | 0.0622663 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0618654 |
| DST | dystonin | 0.0596499 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0581873 |
| ENO1 | enolase 1, (alpha) | 0.0563893 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0523178 |
| CDH13 | cadherin 13 | 0.0509106 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0501711 |
| VCAN | versican | 0.0481134 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.048008 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0478491 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0464136 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0461489 |
| IL6ST | interleukin 6 signal transducer | 0.0455034 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0453916 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0438345 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0422157 |
| NAV1 | neuron navigator 1 | 0.0421895 |
| EGFR | epidermal growth factor receptor | 0.0414777 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0414297 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0414051 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0400273 |
| SMYD3 | SET and MYND domain containing 3 | 0.0398581 |
| SDC2 | syndecan 2 | 0.0398274 |
| PGK1 | phosphoglycerate kinase 1 | 0.0380044 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0378972 |
| MAP1B | microtubule-associated protein 1B | 0.0378422 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0373592 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0373504 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0362328 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0359734 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0359692 |
| RUNX1 | runt-related transcription factor 1 | 0.035032 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0349814 |
| PKM | pyruvate kinase, muscle | 0.034792 |
| POSTN | periostin, osteoblast specific factor | 0.0341223 |
| ASPH | aspartate beta-hydroxylase | 0.0336011 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0326686 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0324231 |
| CPQ | carboxypeptidase Q | 0.0320724 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.031931 |
| HAS2 | hyaluronan synthase 2 | 0.0316557 |
| CD109 | CD109 molecule | 0.0313535 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0313161 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0311587 |
| SBF2 | SET binding factor 2 | 0.0311134 |
| RAD51B | RAD51 paralog B | 0.0309282 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0309025 |
| ATXN1 | ataxin 1 | 0.0305868 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0300008 |
| SEC24A | SEC24 family member A | 0.0299425 |
| NAV2 | neuron navigator 2 | 0.0298786 |
| CNTN5 | contactin 5 | 0.0296823 |
| ATP13A3 | ATPase type 13A3 | 0.0296642 |
| B2M | beta-2-microglobulin | 0.0295626 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0291295 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0289632 |
| COL5A1 | collagen, type V, alpha 1 | 0.0287391 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0285027 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0282368 |
| VCL | vinculin | 0.0280876 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280377 |
| TENM3 | teneurin transmembrane protein 3 | 0.0276406 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0274892 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0271824 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0267536 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0264473 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0264122 |
| YEATS2 | YEATS domain containing 2 | 0.0261775 |
| CENPF | centromere protein F, 350/400kDa | 0.0261707 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0261247 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0258869 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0251967 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0250528 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0248733 |
| SMAD3 | SMAD family member 3 | 0.0248486 |
| MYOF | myoferlin | 0.0247216 |
| MYO1E | myosin IE | 0.0246795 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0245865 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0244145 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0242539 |
| TPI1 | triosephosphate isomerase 1 | 0.0241511 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.118477 |
| NDRG1 | N-myc downstream regulated 1 | -0.0990535 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0470863 |
| PTMA | prothymosin, alpha | -0.0349751 |
| TMSB10 | thymosin beta 10 | -0.0339745 |
| CALR | calreticulin | -0.0335673 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0332168 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0315401 |
| RPL35A | ribosomal protein L35a | -0.0300919 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0291174 |
| RPL28 | ribosomal protein L28 | -0.0247653 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0241399 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0220028 |
| COL1A1 | collagen, type I, alpha 1 | -0.0215121 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0205063 |
| YBX1 | Y box binding protein 1 | -0.0202112 |
| TFG | TRK-fused gene | -0.0193232 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.018948 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0177187 |
| IER3 | immediate early response 3 | -0.0174715 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0170435 |
| IL6 | interleukin 6 | -0.0170105 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0169789 |
| PLEC | plectin | -0.0167488 |
| COL3A1 | collagen, type III, alpha 1 | -0.0167399 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0166315 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.016531 |
| RPS12 | ribosomal protein S12 | -0.0160151 |
| RPL34 | ribosomal protein L34 | -0.0158956 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0158189 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.014405 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0143545 |
| STC1 | stanniocalcin 1 | -0.0143431 |
| RLF | rearranged L-myc fusion | -0.0140246 |
| VEGFA | vascular endothelial growth factor A | -0.013978 |
| RPS3 | ribosomal protein S3 | -0.0139657 |
| RPS2 | ribosomal protein S2 | -0.0135514 |
| RPL5 | ribosomal protein L5 | -0.013408 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0131273 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0129921 |
| RRBP1 | ribosome binding protein 1 | -0.0128517 |
| RPL13A | ribosomal protein L13a | -0.0128244 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0127249 |
| RHEB | Ras homolog enriched in brain | -0.0126666 |
| FTL | ferritin, light polypeptide | -0.0125406 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0124845 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | -0.0123617 |
| TAPBP | TAP binding protein (tapasin) | -0.0123056 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0122361 |
| SRGN | serglycin | -0.0122073 |
| SAFB2 | scaffold attachment factor B2 | -0.0121781 |
| CCNY | cyclin Y | -0.0121695 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0120534 |
| ATF4 | activating transcription factor 4 | -0.0119356 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0118964 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0117366 |
| RPS25 | ribosomal protein S25 | -0.0116365 |
| LAMA5 | laminin, alpha 5 | -0.0115208 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0114021 |
| USP3 | ubiquitin specific peptidase 3 | -0.0113628 |
| SQLE | squalene epoxidase | -0.0112404 |
| FOSL1 | FOS-like antigen 1 | -0.0111468 |
| QKI | QKI, KH domain containing, RNA binding | -0.0110751 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0110491 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0109396 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0108727 |
| FBXO42 | F-box protein 42 | -0.0107917 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.010759 |
| CBFB | core-binding factor, beta subunit | -0.0107356 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | -0.0107103 |
| RHOA | ras homolog family member A | -0.0105673 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.0105526 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0105443 |
| LAMB3 | laminin, beta 3 | -0.0105148 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.010503 |
| RPS24 | ribosomal protein S24 | -0.0104604 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.01044 |
| HYOU1 | hypoxia up-regulated 1 | -0.0104219 |
| PFN1 | profilin 1 | -0.0103343 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0103052 |
| MAP4 | microtubule-associated protein 4 | -0.0102967 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0102121 |
| CLASRP | CLK4-associating serine/arginine rich protein | -0.0101548 |
| SEC61G | Sec61 gamma subunit | -0.0100673 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.00971554 |
| HMGA2 | high mobility group AT-hook 2 | -0.0097019 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.00968508 |
| SDC4 | syndecan 4 | -0.0096761 |
| SAFB | scaffold attachment factor B | -0.00966665 |
| CLMP | CXADR-like membrane protein | -0.00965483 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00965006 |
| RPL26 | ribosomal protein L26 | -0.009642 |
| KAZN | kazrin, periplakin interacting protein | -0.00951781 |
| BMERB1 | bMERB domain containing 1 | -0.0094288 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.00940092 |
| SELENOF | selenoprotein F | -0.00937213 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.00934866 |
| COG5 | component of oligomeric golgi complex 5 | -0.0093338 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.00910185 |
| CFB | complement factor B | -0.00910182 |
