| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC38A2 | solute carrier family 38, member 2 | 0.19995 |
| MT2A | metallothionein 2A | 0.160191 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.124691 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.122754 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.108924 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.106736 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.1016 |
| APOB | apolipoprotein B | 0.0955157 |
| GPC6 | glypican 6 | 0.0901161 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0852691 |
| ATXN1 | ataxin 1 | 0.0849675 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0849516 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0838507 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0834159 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0826597 |
| EHBP1 | EH domain binding protein 1 | 0.082638 |
| FN1 | fibronectin 1 | 0.0771561 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0770597 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0736403 |
| APOA2 | apolipoprotein A-II | 0.0734641 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0719202 |
| FRMD5 | FERM domain containing 5 | 0.0672662 |
| VCL | vinculin | 0.0665896 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0575654 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0565889 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0559407 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0554112 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0541731 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0540111 |
| ASPH | aspartate beta-hydroxylase | 0.0529476 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.052836 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0527574 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0497607 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0496954 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0489269 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0481398 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0477502 |
| JMJD1C | jumonji domain containing 1C | 0.0477428 |
| KIAA1217 | KIAA1217 | 0.0468811 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0466899 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0462688 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0458255 |
| OSMR | oncostatin M receptor | 0.0451891 |
| AHR | aryl hydrocarbon receptor | 0.0448924 |
| ENO1 | enolase 1, (alpha) | 0.0441093 |
| PLIN2 | perilipin 2 | 0.0432469 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0426969 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0424464 |
| FMNL2 | formin-like 2 | 0.0417199 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0411524 |
| FAT1 | FAT atypical cadherin 1 | 0.0402531 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0399038 |
| AFDN | afadin, adherens junction formation factor | 0.0395083 |
| ITGAV | integrin, alpha V | 0.0387249 |
| RPL35A | ribosomal protein L35a | 0.0382817 |
| FHIT | fragile histidine triad | 0.0380209 |
| PRELID2 | PRELI domain containing 2 | 0.0380131 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.037928 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0375969 |
| ATP10A | ATPase, class V, type 10A | 0.0375668 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0371772 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.035148 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.035076 |
| RUNX1 | runt-related transcription factor 1 | 0.0348068 |
| DST | dystonin | 0.034261 |
| STK39 | serine threonine kinase 39 | 0.0337169 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0335345 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0332839 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0330411 |
| PGK1 | phosphoglycerate kinase 1 | 0.0328406 |
| SVIL | supervillin | 0.0327244 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0326779 |
| NHSL1 | NHS-like 1 | 0.0323454 |
| FAM135A | family with sequence similarity 135, member A | 0.0322713 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0318383 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0317077 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0311473 |
| MALT1 | MALT1 paracaspase | 0.0311143 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0304963 |
| JAG1 | jagged 1 | 0.0302811 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0300895 |
| FOXP1 | forkhead box P1 | 0.0297703 |
| MRTFA | myocardin related transcription factor A | 0.0297385 |
| DTNA | dystrobrevin, alpha | 0.0295228 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0295138 |
| CRLS1 | cardiolipin synthase 1 | 0.0292082 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0291781 |
| IGF2 | insulin-like growth factor 2 | 0.0290414 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0289232 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0288981 |
| MED13 | mediator complex subunit 13 | 0.0287053 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0286317 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0285184 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.0284922 |
| ARFGEF3 | ARFGEF family member 3 | 0.0282764 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.028214 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0281906 |
| GPC3 | glypican 3 | 0.0279891 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0278633 |
| FILIP1L | filamin A interacting protein 1-like | 0.0274435 |
| Symbol | Name | Standardized Value |
|---|---|---|
| C3 | complement component 3 | -0.23522 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.161762 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0914562 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0795603 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0589751 |
| NDRG1 | N-myc downstream regulated 1 | -0.0589417 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0584876 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0568216 |
| RPS2 | ribosomal protein S2 | -0.0544172 |
| VEGFA | vascular endothelial growth factor A | -0.0532621 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0513607 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0448225 |
| GOLGA4 | golgin A4 | -0.0429965 |
| LYZ | lysozyme | -0.0381499 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0363862 |
| VMP1 | vacuole membrane protein 1 | -0.0361555 |
| TF | transferrin | -0.0355405 |
| SDC4 | syndecan 4 | -0.0349998 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0331083 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0328116 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0327551 |
| YBX1 | Y box binding protein 1 | -0.0326146 |
| RPL3 | ribosomal protein L3 | -0.030916 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0307211 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0300804 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0281663 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0280291 |
| RPS12 | ribosomal protein S12 | -0.0276396 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0276124 |
| FTL | ferritin, light polypeptide | -0.0275643 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0255826 |
| RYBP | RING1 and YY1 binding protein | -0.0254036 |
| RBM39 | RNA binding motif protein 39 | -0.0249134 |
| ZNF609 | zinc finger protein 609 | -0.0247781 |
| WDR45B | WD repeat domain 45B | -0.024375 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0240807 |
| UBC | ubiquitin C | -0.0239567 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0229838 |
| RBM25 | RNA binding motif protein 25 | -0.0229838 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0227972 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0226886 |
| BRD4 | bromodomain containing 4 | -0.0226208 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.022432 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0224265 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0222229 |
| USP3 | ubiquitin specific peptidase 3 | -0.0221642 |
| MAP4 | microtubule-associated protein 4 | -0.022151 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0219987 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0219331 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0218713 |
| JUN | jun proto-oncogene | -0.0216017 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0215427 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0215389 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0214084 |
| GSPT1 | G1 to S phase transition 1 | -0.0213586 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0212788 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0212408 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.021239 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0209352 |
| SEPTIN9 | septin 9 | -0.0208284 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0207771 |
| ZNF207 | zinc finger protein 207 | -0.0207402 |
| SFTPA2 | surfactant protein A2 | -0.0207196 |
| CTSD | cathepsin D | -0.0207117 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0206633 |
| NRDC | nardilysin convertase | -0.0206279 |
| H1-0 | H1.0 linker histone | -0.0205571 |
| OGA | O-GlcNAcase | -0.0205196 |
| NUP58 | nucleoporin 58 | -0.020398 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0201946 |
| PEG10 | paternally expressed 10 | -0.0201566 |
| WASF2 | WAS protein family, member 2 | -0.0200214 |
| FOXK2 | forkhead box K2 | -0.0199735 |
| ECE1 | endothelin converting enzyme 1 | -0.0199194 |
| RPS14 | ribosomal protein S14 | -0.0198151 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0196571 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0196354 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0194155 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0194069 |
| IPO7 | importin 7 | -0.0193952 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0192301 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0192078 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0191039 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | -0.0189804 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0187218 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0187157 |
| CLIC4 | chloride intracellular channel 4 | -0.0186372 |
| ANKRD11 | ankyrin repeat domain 11 | -0.018589 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0185599 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0184511 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0182344 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0182266 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0182019 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0181017 |
| RPS3 | ribosomal protein S3 | -0.0178944 |
| PHKB | phosphorylase kinase, beta | -0.0178382 |
| BPIFB2 | BPI fold containing family B, member 2 | -0.0177865 |
| USP34 | ubiquitin specific peptidase 34 | -0.0177065 |
| NBEAL1 | neurobeachin-like 1 | -0.0176371 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0176063 |
