| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0977705 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0959857 |
| MEF2A | myocyte enhancer factor 2A | 0.0887937 |
| FLNB | filamin B, beta | 0.0851261 |
| CLU | clusterin | 0.0738346 |
| EFHD2 | EF-hand domain family, member D2 | 0.0733103 |
| NDRG1 | N-myc downstream regulated 1 | 0.0704651 |
| MYOF | myoferlin | 0.063523 |
| TMSB10 | thymosin beta 10 | 0.061235 |
| ITGA6 | integrin, alpha 6 | 0.0566543 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0487132 |
| MT2A | metallothionein 2A | 0.0472298 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0466749 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0465401 |
| PGK1 | phosphoglycerate kinase 1 | 0.0459756 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.045512 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0442959 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0439212 |
| FOXO1 | forkhead box O1 | 0.0431416 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0410036 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0391884 |
| MSN | moesin | 0.0391396 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0388983 |
| EMP1 | epithelial membrane protein 1 | 0.0381858 |
| BCL2L1 | BCL2-like 1 | 0.0375292 |
| OGA | O-GlcNAcase | 0.0369301 |
| YBX3 | Y box binding protein 3 | 0.0368756 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0364528 |
| CUL4B | cullin 4B | 0.0362187 |
| LMNA | lamin A/C | 0.0360501 |
| ANLN | anillin, actin binding protein | 0.0360248 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.035608 |
| KRT17 | keratin 17, type I | 0.0352486 |
| ARRDC3 | arrestin domain containing 3 | 0.0350673 |
| GOLGA4 | golgin A4 | 0.035012 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0348065 |
| MT1X | metallothionein 1X | 0.0343426 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0340664 |
| DSTN | destrin (actin depolymerizing factor) | 0.0331748 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0328764 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0328316 |
| FOSL1 | FOS-like antigen 1 | 0.0322473 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0322323 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0320835 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0311679 |
| ZNF292 | zinc finger protein 292 | 0.0310555 |
| RNF145 | ring finger protein 145 | 0.031001 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0309943 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0309798 |
| PDLIM1 | PDZ and LIM domain 1 | 0.0302359 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0301534 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0295104 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0294333 |
| EZR | ezrin | 0.0291595 |
| ENO1 | enolase 1, (alpha) | 0.0288663 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0287263 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0283846 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0273109 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.027261 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0272161 |
| ADM | adrenomedullin | 0.026746 |
| KIAA1217 | KIAA1217 | 0.0266674 |
| EPHA2 | EPH receptor A2 | 0.0266448 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0266419 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0264392 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0262629 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0262392 |
| PKM | pyruvate kinase, muscle | 0.0261977 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0261204 |
| RTN4 | reticulon 4 | 0.0260944 |
| PRELID2 | PRELI domain containing 2 | 0.0257221 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.025282 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0252013 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0248684 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0247542 |
| CD99 | CD99 molecule | 0.0241274 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0239009 |
| S100A2 | S100 calcium binding protein A2 | 0.0237847 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0237096 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0236796 |
| S100A4 | S100 calcium binding protein A4 | 0.0236488 |
| PCBP2 | poly(rC) binding protein 2 | 0.0233269 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0230302 |
| TAGLN2 | transgelin 2 | 0.0230054 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0229019 |
| PLAT | plasminogen activator, tissue | 0.0227803 |
| GATA6 | GATA binding protein 6 | 0.02275 |
| AFAP1 | actin filament associated protein 1 | 0.0227312 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.0226106 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0225869 |
| S100A6 | S100 calcium binding protein A6 | 0.0225754 |
| GLYAT | glycine-N-acyltransferase | 0.0222285 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0218252 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0218177 |
| PLAC8 | placenta-specific 8 | 0.0212855 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0212269 |
| NUP58 | nucleoporin 58 | 0.0212077 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.021165 |
| NRG1 | neuregulin 1 | 0.0210056 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0209129 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.377842 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.319925 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.113568 |
| LMO7 | LIM domain 7 | -0.109353 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0954416 |
| MTSS1 | metastasis suppressor 1 | -0.095417 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0929154 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0841889 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0834534 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0811997 |
| INTS6 | integrator complex subunit 6 | -0.0774476 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0750645 |
| AHNAK | AHNAK nucleoprotein | -0.0740243 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0739442 |
| HMGA2 | high mobility group AT-hook 2 | -0.069672 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0666151 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0658413 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0619063 |
| EXT1 | exostosin glycosyltransferase 1 | -0.061626 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0614543 |
| CDK6 | cyclin-dependent kinase 6 | -0.0561648 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0532695 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0526529 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.052315 |
| RASAL2 | RAS protein activator like 2 | -0.0519533 |
| PTMA | prothymosin, alpha | -0.0519252 |
| RAI14 | retinoic acid induced 14 | -0.0506872 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0490876 |
| LAMC2 | laminin, gamma 2 | -0.0479163 |
| HM13 | histocompatibility (minor) 13 | -0.0477996 |
| HLA-B | major histocompatibility complex, class I, B | -0.0477513 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0474597 |
| RPS24 | ribosomal protein S24 | -0.0455565 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0452448 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0451141 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0451108 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0448075 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0431849 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.042633 |
| RPS25 | ribosomal protein S25 | -0.0422385 |
| PALLD | palladin, cytoskeletal associated protein | -0.0411073 |
| SULF2 | sulfatase 2 | -0.0409286 |
| HLA-E | major histocompatibility complex, class I, E | -0.0394581 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0388736 |
| PRSS23 | protease, serine, 23 | -0.0385583 |
| MTAP | methylthioadenosine phosphorylase | -0.0382344 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0373859 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0371124 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0370702 |
| RPS8 | ribosomal protein S8 | -0.035916 |
| EGFR | epidermal growth factor receptor | -0.0356077 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0352057 |
| SQSTM1 | sequestosome 1 | -0.0345318 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0340681 |
| SP100 | SP100 nuclear antigen | -0.0340294 |
| CNTNAP3 | contactin associated protein-like 3 | -0.0339952 |
| EXOC4 | exocyst complex component 4 | -0.0338145 |
| CUX1 | cut-like homeobox 1 | -0.0332985 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0325412 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0322144 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.032212 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0319836 |
| RAD51B | RAD51 paralog B | -0.0318696 |
| RPLP1 | ribosomal protein, large, P1 | -0.0318067 |
| RPL26 | ribosomal protein L26 | -0.0316776 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0315548 |
| AOPEP | aminopeptidase O (putative) | -0.0312751 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0310912 |
| DGKH | diacylglycerol kinase, eta | -0.0308688 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0307689 |
| HDAC9 | histone deacetylase 9 | -0.0305612 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0302069 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0300097 |
| EFNA5 | ephrin-A5 | -0.0294991 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0291738 |
| THBD | thrombomodulin | -0.0291685 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0290896 |
| IFI44L | interferon-induced protein 44-like | -0.0289898 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0288548 |
| ACTG1 | actin gamma 1 | -0.0288484 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0288434 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0287156 |
| PLS3 | plastin 3 | -0.0283399 |
| UTRN | utrophin | -0.0282724 |
| TNS3 | tensin 3 | -0.0280752 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0280143 |
| RPL31 | ribosomal protein L31 | -0.0278239 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0277125 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0272254 |
| SYN3 | synapsin III | -0.0267554 |
| RPS27A | ribosomal protein S27a | -0.0265328 |
| PODXL | podocalyxin-like | -0.0263744 |
| ECE1 | endothelin converting enzyme 1 | -0.0262223 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.026197 |
| DST | dystonin | -0.0261933 |
| DENND1A | DENN/MADD domain containing 1A | -0.026054 |
| KIAA1671 | KIAA1671 | -0.0256238 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0252222 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0250179 |
| MECOM | MDS1 and EVI1 complex locus | -0.0249836 |
