| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.21078 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.129168 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.126819 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.125321 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.116509 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.111426 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0944484 |
| ITGA6 | integrin, alpha 6 | 0.09264 |
| MYOF | myoferlin | 0.0914884 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0845804 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0844008 |
| TES | testin LIM domain protein | 0.0810351 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.075422 |
| ZNF292 | zinc finger protein 292 | 0.0736754 |
| PGK1 | phosphoglycerate kinase 1 | 0.0729183 |
| DSPP | dentin sialophosphoprotein | 0.0721733 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0652532 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0612155 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0610631 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0608948 |
| TXNRD1 | thioredoxin reductase 1 | 0.0594363 |
| FLNB | filamin B, beta | 0.0574583 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0556327 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0545676 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0538685 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0536974 |
| ANXA2 | annexin A2 | 0.0533376 |
| PCBP2 | poly(rC) binding protein 2 | 0.0524922 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0521196 |
| PRELID2 | PRELI domain containing 2 | 0.0488928 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0485182 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0484826 |
| NEK7 | NIMA-related kinase 7 | 0.0484748 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0484017 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0478662 |
| CD2AP | CD2-associated protein | 0.0475848 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0473662 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0465362 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0464022 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.045493 |
| FAM13A | family with sequence similarity 13, member A | 0.0443832 |
| B2M | beta-2-microglobulin | 0.0429342 |
| WWC1 | WW and C2 domain containing 1 | 0.0427656 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0426317 |
| STK24 | serine/threonine kinase 24 | 0.0423916 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0422751 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0417759 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0412979 |
| ATXN1 | ataxin 1 | 0.0412317 |
| SNX9 | sorting nexin 9 | 0.0412205 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0406855 |
| CAPN8 | calpain 8 | 0.0404455 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0401034 |
| GPX2 | glutathione peroxidase 2 | 0.0397557 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0396095 |
| FAM135A | family with sequence similarity 135, member A | 0.0395193 |
| YEATS2 | YEATS domain containing 2 | 0.0389749 |
| KRT19 | keratin 19, type I | 0.0389333 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0387122 |
| GOLGA4 | golgin A4 | 0.0385316 |
| ECT2 | epithelial cell transforming 2 | 0.0379638 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0379589 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0379437 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0376406 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0372706 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0367776 |
| ANXA11 | annexin A11 | 0.0366575 |
| CCNY | cyclin Y | 0.0364113 |
| TMF1 | TATA element modulatory factor 1 | 0.0363716 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0361079 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0361001 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0360495 |
| PLS1 | plastin 1 | 0.0359826 |
| FAT1 | FAT atypical cadherin 1 | 0.0358245 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0357531 |
| PLSCR1 | phospholipid scramblase 1 | 0.0356756 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0356146 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0356107 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0355499 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0354577 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0352317 |
| NF1 | neurofibromin 1 | 0.035219 |
| HELZ | helicase with zinc finger | 0.0349521 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0349039 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0348913 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0347999 |
| EMP1 | epithelial membrane protein 1 | 0.0338896 |
| ANLN | anillin, actin binding protein | 0.0337106 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0333333 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0330288 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0329846 |
| NFIB | nuclear factor I/B | 0.032971 |
| CLTC | clathrin, heavy chain (Hc) | 0.03277 |
| SNX13 | sorting nexin 13 | 0.0324402 |
| RPN1 | ribophorin I | 0.0323124 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0321996 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0321135 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0314661 |
| ANO6 | anoctamin 6 | 0.0314637 |
| KRT18 | keratin 18, type I | 0.0308259 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.093464 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0906596 |
| TMSB10 | thymosin beta 10 | -0.0823102 |
| PTMA | prothymosin, alpha | -0.0804609 |
| NPSR1 | neuropeptide S receptor 1 | -0.0760047 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0544184 |
| MCU | mitochondrial calcium uniporter | -0.0426242 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0411409 |
| ACTG1 | actin gamma 1 | -0.0410018 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0384296 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0363146 |
| HLA-B | major histocompatibility complex, class I, B | -0.0337524 |
| RPS3 | ribosomal protein S3 | -0.0313576 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0303916 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0298524 |
| FASN | fatty acid synthase | -0.0289762 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0282167 |
| FDPS | farnesyl diphosphate synthase | -0.0279612 |
| INSIG1 | insulin induced gene 1 | -0.0278496 |
| LMNA | lamin A/C | -0.0273714 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0271442 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0270747 |
| RRBP1 | ribosome binding protein 1 | -0.0269736 |
| AOPEP | aminopeptidase O (putative) | -0.0267931 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0266423 |
| RPL35A | ribosomal protein L35a | -0.0264884 |
| AGR3 | anterior gradient 3 | -0.0260736 |
| FMNL2 | formin-like 2 | -0.0260268 |
| CALR | calreticulin | -0.0259435 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0243982 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0239934 |
| ACLY | ATP citrate lyase | -0.0236062 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0233519 |
| FUS | FUS RNA binding protein | -0.0229007 |
| SSH2 | slingshot protein phosphatase 2 | -0.0225106 |
| GNAS | GNAS complex locus | -0.0221359 |
| COBL | cordon-bleu WH2 repeat protein | -0.0220914 |
| INTS6 | integrator complex subunit 6 | -0.021925 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0218047 |
| CDK6 | cyclin-dependent kinase 6 | -0.0217329 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0212275 |
| RPS24 | ribosomal protein S24 | -0.0211869 |
| HLA-E | major histocompatibility complex, class I, E | -0.0206753 |
| CCND1 | cyclin D1 | -0.0206703 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0205086 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.020488 |
| IER3 | immediate early response 3 | -0.0198649 |
| VCP | valosin containing protein | -0.0196164 |
| PPP1R1B | protein phosphatase 1, regulatory (inhibitor) subunit 1B | -0.0192453 |
| RPS27A | ribosomal protein S27a | -0.0188744 |
| KLF6 | Kruppel-like factor 6 | -0.0187263 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0184849 |
| SP100 | SP100 nuclear antigen | -0.0183368 |
| RPL34 | ribosomal protein L34 | -0.0183149 |
| RASAL2 | RAS protein activator like 2 | -0.0182831 |
| NPR2 | natriuretic peptide receptor 2 | -0.0181103 |
| WDR45B | WD repeat domain 45B | -0.0179851 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0178768 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0178741 |
| PLEC | plectin | -0.0178475 |
| RPS29 | ribosomal protein S29 | -0.0169424 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.016831 |
| RPL7A | ribosomal protein L7a | -0.0164836 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0164254 |
| HMGB1 | high mobility group box 1 | -0.0163296 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0163037 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0162601 |
| RPL12 | ribosomal protein L12 | -0.0162072 |
| AXIN2 | axin 2 | -0.0160819 |
| HM13 | histocompatibility (minor) 13 | -0.0160677 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0160321 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.01597 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0159506 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0159096 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0159096 |
| HLA-C | major histocompatibility complex, class I, C | -0.0157588 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0157496 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.0157131 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0156554 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0156433 |
| RIGI | RNA sensor RIG-I | -0.0155373 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0154768 |
| YBX1 | Y box binding protein 1 | -0.0153426 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.0150514 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0148326 |
| RPL26 | ribosomal protein L26 | -0.014795 |
| NOP58 | NOP58 ribonucleoprotein | -0.0146384 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0145102 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0143978 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.014363 |
| RUNX1 | runt-related transcription factor 1 | -0.0142668 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0142397 |
| APOL1 | apolipoprotein L, 1 | -0.0142089 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0139663 |
| RPS23 | ribosomal protein S23 | -0.0139474 |
| RPL36A | ribosomal protein L36a | -0.0137526 |
| PRSS23 | protease, serine, 23 | -0.0136701 |
| CUX1 | cut-like homeobox 1 | -0.0136187 |
| ALDOC | aldolase C, fructose-bisphosphate | -0.0136113 |
| RRM2 | ribonucleotide reductase M2 | -0.01351 |
