| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.120625 |
| TNS4 | tensin 4 | 0.11063 |
| PRELID2 | PRELI domain containing 2 | 0.107323 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.101133 |
| RNF43 | ring finger protein 43 | 0.0927553 |
| FAM13A | family with sequence similarity 13, member A | 0.0881815 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.079545 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0776494 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0698743 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0626864 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.060692 |
| PTEN | phosphatase and tensin homolog | 0.0585646 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0576588 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0570638 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0557031 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0551066 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0524305 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0523608 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0512526 |
| ITGA6 | integrin, alpha 6 | 0.0491419 |
| PKM | pyruvate kinase, muscle | 0.0488794 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.04746 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0469478 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0466619 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0463798 |
| FLNB | filamin B, beta | 0.0462187 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0460574 |
| ZNF292 | zinc finger protein 292 | 0.0455578 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0453816 |
| LDHA | lactate dehydrogenase A | 0.043708 |
| PRSS3 | protease, serine, 3 | 0.0436264 |
| ABHD2 | abhydrolase domain containing 2 | 0.0433273 |
| PGK1 | phosphoglycerate kinase 1 | 0.043248 |
| GPHN | gephyrin | 0.043054 |
| AREG | amphiregulin | 0.0429358 |
| CDK19 | cyclin-dependent kinase 19 | 0.0421528 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0414005 |
| NDRG1 | N-myc downstream regulated 1 | 0.0412135 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0411584 |
| EREG | epiregulin | 0.0403425 |
| FHIT | fragile histidine triad | 0.0398159 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0393457 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0380468 |
| ATXN1 | ataxin 1 | 0.037553 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0374954 |
| NPSR1 | neuropeptide S receptor 1 | 0.0364845 |
| CALB1 | calbindin 1, 28kDa | 0.0364827 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0357972 |
| RPS6 | ribosomal protein S6 | 0.0355048 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0354181 |
| NEBL | nebulette | 0.0350224 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0347314 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.0345496 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0344906 |
| PCDHB16 | protocadherin beta 16 | 0.0344746 |
| INSIG1 | insulin induced gene 1 | 0.0340691 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0339056 |
| RAD51B | RAD51 paralog B | 0.033833 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0333942 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.03327 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0331704 |
| NFIA | nuclear factor I/A | 0.033067 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0326938 |
| RPL9 | ribosomal protein L9 | 0.0326159 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0320428 |
| PLEK2 | pleckstrin 2 | 0.0317563 |
| SMYD3 | SET and MYND domain containing 3 | 0.030905 |
| DSCAM | Down syndrome cell adhesion molecule | 0.030789 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0307882 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0306752 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0305538 |
| KIF16B | kinesin family member 16B | 0.0305066 |
| PCBP2 | poly(rC) binding protein 2 | 0.0301822 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0299193 |
| EHF | ets homologous factor | 0.0298586 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0294218 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0292643 |
| FOXP1 | forkhead box P1 | 0.0291176 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0289703 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0285142 |
| RPL11 | ribosomal protein L11 | 0.028512 |
| RPL7 | ribosomal protein L7 | 0.0282051 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0280524 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0276473 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0276249 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0275946 |
| CCNY | cyclin Y | 0.027538 |
| RBM47 | RNA binding motif protein 47 | 0.0273641 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0272888 |
| RREB1 | ras responsive element binding protein 1 | 0.0272169 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0270698 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0269712 |
| ZNF638 | zinc finger protein 638 | 0.026904 |
| ABHD17C | abhydrolase domain containing 17C | 0.026893 |
| YEATS2 | YEATS domain containing 2 | 0.0265114 |
| SNX13 | sorting nexin 13 | 0.0264393 |
| EPCAM | epithelial cell adhesion molecule | 0.026432 |
| INSIG2 | insulin induced gene 2 | 0.0263443 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0260801 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0259831 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.255922 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.172894 |
| PTMA | prothymosin, alpha | -0.145911 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.1027 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0999645 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0980894 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.085522 |
| MYO1E | myosin IE | -0.0716655 |
| EZR | ezrin | -0.0715636 |
| LMO7 | LIM domain 7 | -0.0600786 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0537916 |
| ACTG1 | actin gamma 1 | -0.0502342 |
| AHNAK | AHNAK nucleoprotein | -0.0494649 |
| YBX1 | Y box binding protein 1 | -0.0483742 |
| TMSB10 | thymosin beta 10 | -0.0467854 |
| RPS2 | ribosomal protein S2 | -0.0457636 |
| PIGR | polymeric immunoglobulin receptor | -0.0457247 |
| ANXA1 | annexin A1 | -0.0435906 |
| TPM4 | tropomyosin 4 | -0.0412033 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0411368 |
| S100A10 | S100 calcium binding protein A10 | -0.0402129 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0396846 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0396633 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0386268 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0384487 |
| CALR | calreticulin | -0.0383271 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0365331 |
| H1-0 | H1.0 linker histone | -0.03643 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0361746 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.035582 |
| KRT18 | keratin 18, type I | -0.0340303 |
| FBXO11 | F-box protein 11 | -0.0332795 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0324588 |
| TFF1 | trefoil factor 1 | -0.031039 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0309486 |
| HDLBP | high density lipoprotein binding protein | -0.0305249 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | -0.0299275 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0295519 |
| CUX1 | cut-like homeobox 1 | -0.029393 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0292356 |
| JUN | jun proto-oncogene | -0.0291352 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0291348 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0274793 |
| AGR2 | anterior gradient 2 | -0.0274157 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0273234 |
| NOP58 | NOP58 ribonucleoprotein | -0.0273171 |
| EMP1 | epithelial membrane protein 1 | -0.0265779 |
| CLOCK | clock circadian regulator | -0.0264226 |
| VCL | vinculin | -0.0263414 |
| RPS27A | ribosomal protein S27a | -0.0261359 |
| MUC17 | mucin 17, cell surface associated | -0.0261338 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0255798 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0253944 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0251698 |
| USP53 | ubiquitin specific peptidase 53 | -0.025154 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0251415 |
| IER3 | immediate early response 3 | -0.0251241 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0248934 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0247797 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0247258 |
| ASPH | aspartate beta-hydroxylase | -0.0246441 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0242508 |
| TJP1 | tight junction protein 1 | -0.0242055 |
| RPS24 | ribosomal protein S24 | -0.0241034 |
| SVIL | supervillin | -0.0239541 |
| ATF3 | activating transcription factor 3 | -0.023892 |
| FUS | FUS RNA binding protein | -0.0236977 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0233552 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0229672 |
| RND3 | Rho family GTPase 3 | -0.0227066 |
| HDAC2 | histone deacetylase 2 | -0.0226216 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0223877 |
| APP | amyloid beta (A4) precursor protein | -0.0222191 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0221636 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0220159 |
| RPL6 | ribosomal protein L6 | -0.0219196 |
| CCND1 | cyclin D1 | -0.0216408 |
| STK17A | serine/threonine kinase 17a | -0.0216168 |
| SQSTM1 | sequestosome 1 | -0.0216087 |
| LAMA4 | laminin, alpha 4 | -0.0215581 |
| GSPT1 | G1 to S phase transition 1 | -0.0214259 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0214179 |
| NPR2 | natriuretic peptide receptor 2 | -0.0213629 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0211645 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.021118 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0208697 |
| HMGB1 | high mobility group box 1 | -0.0208159 |
| CANX | calnexin | -0.0207746 |
| RORA | RAR-related orphan receptor A | -0.0207565 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0206366 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0205747 |
| FAM107B | family with sequence similarity 107, member B | -0.0205605 |
| GDF15 | growth differentiation factor 15 | -0.020385 |
| SIK3 | SIK family kinase 3 | -0.0203842 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0202758 |
| POF1B | premature ovarian failure, 1B | -0.0198611 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0198601 |
| RPLP1 | ribosomal protein, large, P1 | -0.019771 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0197298 |
| MLF1 | myeloid leukemia factor 1 | -0.0194318 |
