| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Simotinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.155795 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.126348 |
| CENPF | centromere protein F, 350/400kDa | 0.109192 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.10699 |
| SLC38A2 | solute carrier family 38, member 2 | 0.101931 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0891521 |
| POTEF | POTE ankyrin domain family, member F | 0.0853546 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0844458 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0822974 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0791395 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0767398 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0756977 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0724585 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0711745 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0701248 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0699311 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0663371 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0628767 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0582625 |
| MKI67 | marker of proliferation Ki-67 | 0.0571649 |
| JMJD1C | jumonji domain containing 1C | 0.0545673 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0514665 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0494917 |
| RTN4 | reticulon 4 | 0.0489684 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0484086 |
| RTTN | rotatin | 0.047922 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0478269 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0473929 |
| EGR1 | early growth response 1 | 0.0458918 |
| SRPK2 | SRSF protein kinase 2 | 0.0458658 |
| USP34 | ubiquitin specific peptidase 34 | 0.0458601 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0453249 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0443424 |
| FNIP1 | folliculin interacting protein 1 | 0.0436397 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0427848 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0425633 |
| NUP58 | nucleoporin 58 | 0.042555 |
| DIAPH3 | diaphanous-related formin 3 | 0.0415212 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0414603 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0414058 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.041398 |
| TOP1 | topoisomerase (DNA) I | 0.0411035 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0409257 |
| RAI1 | retinoic acid induced 1 | 0.0400839 |
| TMEM41B | transmembrane protein 41B | 0.0399439 |
| SON | SON DNA binding protein | 0.03955 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0385916 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0379071 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0377024 |
| ANLN | anillin, actin binding protein | 0.0376726 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0376667 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0371865 |
| LDHA | lactate dehydrogenase A | 0.0371286 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0368273 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0363609 |
| RCOR1 | REST corepressor 1 | 0.0356447 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0354376 |
| MATR3 | matrin 3 | 0.0353547 |
| PKM | pyruvate kinase, muscle | 0.0350193 |
| ETNK1 | ethanolamine kinase 1 | 0.0339624 |
| ECT2 | epithelial cell transforming 2 | 0.0336883 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0336758 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0336569 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0336463 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0332263 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0328927 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.032874 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.032833 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0327562 |
| SBF2 | SET binding factor 2 | 0.0325556 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0323793 |
| ZNF292 | zinc finger protein 292 | 0.0322648 |
| GOLGA4 | golgin A4 | 0.0320348 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0320312 |
| ERBIN | erbb2 interacting protein | 0.0320169 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0319995 |
| SGO2 | shugoshin 2 | 0.031908 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0315451 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0314983 |
| PGK1 | phosphoglycerate kinase 1 | 0.0314838 |
| MSN | moesin | 0.0314267 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0312198 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0301151 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0300021 |
| SPAG9 | sperm associated antigen 9 | 0.0297432 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0296884 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0296777 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0292672 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0292629 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0292017 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0291001 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.029007 |
| TPX2 | TPX2, microtubule-associated | 0.0289062 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0288882 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0287092 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0286135 |
| HJURP | Holliday junction recognition protein | 0.0281484 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0280337 |
| RRM2 | ribonucleotide reductase M2 | 0.0280314 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0278817 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.182981 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.134406 |
| HLA-B | major histocompatibility complex, class I, B | -0.133722 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.112161 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0984373 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0916728 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0905975 |
| CADM2 | cell adhesion molecule 2 | -0.0855205 |
| CD44 | CD44 molecule (Indian blood group) | -0.0837306 |
| TNS3 | tensin 3 | -0.0804067 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0771997 |
| RIGI | RNA sensor RIG-I | -0.0765276 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0711232 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0705163 |
| VIM | vimentin | -0.0679666 |
| PTMA | prothymosin, alpha | -0.0653268 |
| EFNA5 | ephrin-A5 | -0.0598689 |
| RNF213 | ring finger protein 213 | -0.0587343 |
| EPHA4 | EPH receptor A4 | -0.0585361 |
| MT2A | metallothionein 2A | -0.057446 |
| DNER | delta/notch-like EGF repeat containing | -0.0554111 |
| RPS6 | ribosomal protein S6 | -0.0553644 |
| RPL35A | ribosomal protein L35a | -0.0540931 |
| RPL36 | ribosomal protein L36 | -0.0533655 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0512709 |
| FTL | ferritin, light polypeptide | -0.0503934 |
| DST | dystonin | -0.0494968 |
| RPL37A | ribosomal protein L37a | -0.0484783 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0475531 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0472615 |
| SP100 | SP100 nuclear antigen | -0.0470835 |
| RPS19 | ribosomal protein S19 | -0.0467564 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0459379 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.045626 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0454356 |
| TRIM56 | tripartite motif containing 56 | -0.0448885 |
| TMSB4X | thymosin beta 4, X-linked | -0.0446918 |
| RPL31 | ribosomal protein L31 | -0.0444629 |
| RPL36A | ribosomal protein L36a | -0.0420666 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.042049 |
| HDAC9 | histone deacetylase 9 | -0.0418903 |
| RPL26 | ribosomal protein L26 | -0.0415037 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0402702 |
| HLA-E | major histocompatibility complex, class I, E | -0.0398489 |
| TMSB10 | thymosin beta 10 | -0.0396263 |
| PDE10A | phosphodiesterase 10A | -0.0391317 |
| RPS8 | ribosomal protein S8 | -0.038884 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0373859 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0363875 |
| RPL37 | ribosomal protein L37 | -0.035931 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0354887 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.034864 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.0342152 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0334892 |
| RPL12 | ribosomal protein L12 | -0.0326662 |
| RPS3 | ribosomal protein S3 | -0.0322342 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0318026 |
| RPS27A | ribosomal protein S27a | -0.0311985 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0307993 |
| RPLP1 | ribosomal protein, large, P1 | -0.0298708 |
| ENOSF1 | enolase superfamily member 1 | -0.0292089 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0290036 |
| RPL38 | ribosomal protein L38 | -0.028963 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0288327 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0279837 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0271732 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0269981 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0267521 |
| RPS29 | ribosomal protein S29 | -0.0265932 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0265898 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0259644 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.025857 |
| ECE1 | endothelin converting enzyme 1 | -0.0253759 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0250135 |
| RPLP2 | ribosomal protein, large, P2 | -0.0245244 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.024452 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0241608 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0240947 |
| RPL35 | ribosomal protein L35 | -0.0238393 |
| APP | amyloid beta (A4) precursor protein | -0.0238247 |
| RPL28 | ribosomal protein L28 | -0.0236578 |
| PLSCR1 | phospholipid scramblase 1 | -0.0236284 |
| B2M | beta-2-microglobulin | -0.0231154 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.022992 |
| ANGPTL4 | angiopoietin-like 4 | -0.0229039 |
| RPS27 | ribosomal protein S27 | -0.0225344 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0224979 |
| AMPD3 | adenosine monophosphate deaminase 3 | -0.0224619 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | -0.0222382 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0221238 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0219921 |
| EGFR | epidermal growth factor receptor | -0.0213934 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0213762 |
| DPH6 | diphthamine biosynthesis 6 | -0.0213143 |
| RPL7A | ribosomal protein L7a | -0.021192 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0210566 |
| TGM2 | transglutaminase 2 | -0.0209602 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0209459 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0209059 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0208273 |
