| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.282325 |
| TXNRD1 | thioredoxin reductase 1 | 0.144892 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0898191 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0895707 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0840606 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0713986 |
| FAM13A | family with sequence similarity 13, member A | 0.070634 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0680718 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0566932 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0560458 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0515895 |
| FTL | ferritin, light polypeptide | 0.0464016 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0444397 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0443086 |
| CPE | carboxypeptidase E | 0.0442858 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0428002 |
| ARRDC3 | arrestin domain containing 3 | 0.0417223 |
| PCBP2 | poly(rC) binding protein 2 | 0.0386141 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0371229 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0369581 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0358809 |
| B2M | beta-2-microglobulin | 0.0355109 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0323797 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0323379 |
| TPD52 | tumor protein D52 | 0.0322358 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0299337 |
| LMO7 | LIM domain 7 | 0.0298605 |
| NGLY1 | N-glycanase 1 | 0.0298585 |
| RNF145 | ring finger protein 145 | 0.029659 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0285445 |
| CCNL1 | cyclin L1 | 0.0270403 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0265657 |
| PGK1 | phosphoglycerate kinase 1 | 0.0264889 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0263781 |
| TES | testin LIM domain protein | 0.0256832 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0253171 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0251027 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0243785 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0240156 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0238815 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0237342 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0236295 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0235833 |
| MGAT4C | MGAT4 family, member C | 0.0235444 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0235122 |
| CST3 | cystatin C | 0.0232973 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0232352 |
| LDHA | lactate dehydrogenase A | 0.0229036 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0228986 |
| PKM | pyruvate kinase, muscle | 0.022291 |
| PDE8A | phosphodiesterase 8A | 0.0221242 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0220078 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0216704 |
| RAD51B | RAD51 paralog B | 0.0216466 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0214749 |
| HELZ | helicase with zinc finger | 0.0213506 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0213412 |
| UBC | ubiquitin C | 0.021173 |
| EFNA5 | ephrin-A5 | 0.0210837 |
| RAB27B | RAB27B, member RAS oncogene family | 0.02097 |
| AREG | amphiregulin | 0.0209465 |
| UVRAG | UV radiation resistance associated | 0.0208929 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0207746 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0201962 |
| YBX3 | Y box binding protein 3 | 0.0201357 |
| MT1X | metallothionein 1X | 0.0200885 |
| MKI67 | marker of proliferation Ki-67 | 0.0200677 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0200231 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0197613 |
| RNF149 | ring finger protein 149 | 0.0197193 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0191259 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0189813 |
| RPLP0 | ribosomal protein, large, P0 | 0.0187209 |
| UBAC2 | UBA domain containing 2 | 0.0186151 |
| MATR3 | matrin 3 | 0.0182997 |
| PRDX1 | peroxiredoxin 1 | 0.0182166 |
| LAMA4 | laminin, alpha 4 | 0.0182162 |
| TMEM165 | transmembrane protein 165 | 0.0180519 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0178655 |
| PTEN | phosphatase and tensin homolog | 0.017639 |
| TBK1 | TANK-binding kinase 1 | 0.0175493 |
| NPTN | neuroplastin | 0.0172088 |
| GPC6 | glypican 6 | 0.0170727 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0169683 |
| YTHDC1 | YTH domain containing 1 | 0.0169221 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0167923 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.016777 |
| SYAP1 | synapse associated protein 1 | 0.0167615 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0167489 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0167356 |
| THOC2 | THO complex 2 | 0.016685 |
| MYOF | myoferlin | 0.0165794 |
| BBX | bobby sox homolog (Drosophila) | 0.0165668 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.01655 |
| IRS2 | insulin receptor substrate 2 | 0.0163698 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0162939 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0160603 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0160049 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0158955 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0158945 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.085565 |
| EGFR | epidermal growth factor receptor | -0.0724434 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0605794 |
| LAMC2 | laminin, gamma 2 | -0.0567093 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0484399 |
| AHNAK | AHNAK nucleoprotein | -0.0478692 |
| INTS6 | integrator complex subunit 6 | -0.0476179 |
| SLTM | SAFB-like, transcription modulator | -0.0453282 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0443824 |
| GOLGB1 | golgin B1 | -0.043333 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0415986 |
| CANX | calnexin | -0.0386125 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0383918 |
| ACTG1 | actin gamma 1 | -0.0377764 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0377737 |
| PTMA | prothymosin, alpha | -0.0365775 |
| HDLBP | high density lipoprotein binding protein | -0.0353275 |
| STC1 | stanniocalcin 1 | -0.0335694 |
| H1-0 | H1.0 linker histone | -0.030202 |
| PLEC | plectin | -0.0294555 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0292673 |
| GM2A | GM2 ganglioside activator | -0.0291131 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0284178 |
| CDCP1 | CUB domain containing protein 1 | -0.0282612 |
| HOMER1 | homer scaffolding protein 1 | -0.0277778 |
| ASPH | aspartate beta-hydroxylase | -0.0264353 |
| ENSA | endosulfine alpha | -0.0260839 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0258318 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0257766 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0252416 |
| AGR2 | anterior gradient 2 | -0.0250364 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.024681 |
| TPM4 | tropomyosin 4 | -0.0241838 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0240455 |
| ATG7 | autophagy related 7 | -0.0238326 |
| GOLGA3 | golgin A3 | -0.023544 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0229713 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0228614 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0223453 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0222297 |
| KRT18 | keratin 18, type I | -0.0221153 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0215685 |
| MYO1E | myosin IE | -0.021418 |
| ABLIM1 | actin binding LIM protein 1 | -0.0200509 |
| CUX1 | cut-like homeobox 1 | -0.0197671 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0194947 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0191981 |
| ARF1 | ADP-ribosylation factor 1 | -0.0191937 |
| PYGL | phosphorylase, glycogen, liver | -0.019113 |
| HYOU1 | hypoxia up-regulated 1 | -0.0187818 |
| ATF6 | activating transcription factor 6 | -0.0183571 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0183272 |
| EHBP1 | EH domain binding protein 1 | -0.0182925 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0182798 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0180959 |
| SRP72 | signal recognition particle 72kDa | -0.0179076 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0178693 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0176256 |
| HM13 | histocompatibility (minor) 13 | -0.0174206 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0172661 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0172463 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0170326 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.016886 |
| FUS | FUS RNA binding protein | -0.0167587 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0166298 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0165904 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0165209 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0165134 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.016268 |
| MORF4L2 | mortality factor 4 like 2 | -0.0162543 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0161263 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0161148 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0158977 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0156434 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0155513 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0153189 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0151386 |
| USP53 | ubiquitin specific peptidase 53 | -0.0150705 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0150098 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.014847 |
| SEC24D | SEC24 family member D | -0.0148034 |
| SMAD3 | SMAD family member 3 | -0.0148014 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0146295 |
| ANXA2 | annexin A2 | -0.014623 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0145735 |
| DSG2 | desmoglein 2 | -0.014557 |
| ATXN1 | ataxin 1 | -0.0143647 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0142868 |
| SDC4 | syndecan 4 | -0.0142462 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0139791 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0139689 |
| EXOC4 | exocyst complex component 4 | -0.0137982 |
| SP100 | SP100 nuclear antigen | -0.0135367 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0134104 |
| IER3 | immediate early response 3 | -0.0133943 |
| RSRP1 | arginine/serine-rich protein 1 | -0.0133697 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0133527 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0133209 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0132961 |
| ARCN1 | archain 1 | -0.0131793 |
