| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.203522 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.178232 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.14328 |
| FNDC3B | fibronectin type III domain containing 3B | 0.13322 |
| FAM13A | family with sequence similarity 13, member A | 0.126536 |
| GPC6 | glypican 6 | 0.113975 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.105809 |
| PRELID2 | PRELI domain containing 2 | 0.101151 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0827995 |
| SMAD3 | SMAD family member 3 | 0.0673266 |
| RAD51B | RAD51 paralog B | 0.0635717 |
| ZNF292 | zinc finger protein 292 | 0.0608012 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0603558 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0600553 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0595968 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0590092 |
| PCBP2 | poly(rC) binding protein 2 | 0.0587651 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0581756 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0560622 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0556659 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0542423 |
| EFNA5 | ephrin-A5 | 0.053662 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0532984 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0524795 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0523869 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.046559 |
| RUNX2 | runt-related transcription factor 2 | 0.0464798 |
| LDHA | lactate dehydrogenase A | 0.0452293 |
| RUNX1 | runt-related transcription factor 1 | 0.045105 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0450576 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0450247 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0449755 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0438508 |
| HELZ | helicase with zinc finger | 0.0429332 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.042442 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.042094 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0420338 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0411814 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0409595 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0403463 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0402915 |
| NAV2 | neuron navigator 2 | 0.040208 |
| FLNB | filamin B, beta | 0.0392544 |
| MYOF | myoferlin | 0.0391145 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0384932 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0379485 |
| ADD3 | adducin 3 (gamma) | 0.0373118 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.03718 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0370997 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0362817 |
| ATP13A3 | ATPase type 13A3 | 0.036245 |
| ANXA1 | annexin A1 | 0.0362258 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0361438 |
| NGLY1 | N-glycanase 1 | 0.0361117 |
| USP34 | ubiquitin specific peptidase 34 | 0.0360603 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0357625 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0356758 |
| ATXN1 | ataxin 1 | 0.0353337 |
| RARB | retinoic acid receptor, beta | 0.0352646 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0349969 |
| DST | dystonin | 0.0347469 |
| ASPH | aspartate beta-hydroxylase | 0.0345384 |
| RBM39 | RNA binding motif protein 39 | 0.0344759 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0344074 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.033953 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0338123 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0338075 |
| YEATS2 | YEATS domain containing 2 | 0.0328582 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0328104 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0326077 |
| MEF2A | myocyte enhancer factor 2A | 0.0325227 |
| ZNF638 | zinc finger protein 638 | 0.0317023 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0307303 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0299996 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0299729 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0299457 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0299163 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0296553 |
| PFKP | phosphofructokinase, platelet | 0.0294749 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0294298 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0284939 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0284606 |
| NRG4 | neuregulin 4 | 0.0280947 |
| PKM | pyruvate kinase, muscle | 0.0279907 |
| B2M | beta-2-microglobulin | 0.0277967 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0276767 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0274015 |
| OGA | O-GlcNAcase | 0.0273772 |
| LRRC49 | leucine rich repeat containing 49 | 0.027057 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0266769 |
| SBF2 | SET binding factor 2 | 0.0261743 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0261587 |
| TXNRD1 | thioredoxin reductase 1 | 0.0261391 |
| ARRDC3 | arrestin domain containing 3 | 0.0261388 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0255233 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0254796 |
| RPL4 | ribosomal protein L4 | 0.0251571 |
| CANX | calnexin | 0.0250824 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0248475 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0248189 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GLCCI1 | glucocorticoid induced 1 | -0.0701888 |
| TMSB10 | thymosin beta 10 | -0.0658905 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0595803 |
| NTN4 | netrin 4 | -0.0481835 |
| STC1 | stanniocalcin 1 | -0.0414068 |
| LOX | lysyl oxidase | -0.0400909 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0394277 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0372778 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0371694 |
| HMGA2 | high mobility group AT-hook 2 | -0.0361643 |
| AADAC | arylacetamide deacetylase | -0.0351423 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0348647 |
| EGR1 | early growth response 1 | -0.0342775 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0336577 |
| VRK2 | vaccinia related kinase 2 | -0.0318689 |
| MT2A | metallothionein 2A | -0.031309 |
| VIM | vimentin | -0.0307832 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0294555 |
| NRG1 | neuregulin 1 | -0.0291554 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0285403 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0276518 |
| CLMP | CXADR-like membrane protein | -0.0260507 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0255258 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0254945 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0249259 |
| VMP1 | vacuole membrane protein 1 | -0.0246016 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.02455 |
| PTMA | prothymosin, alpha | -0.0235906 |
| VEGFA | vascular endothelial growth factor A | -0.0235578 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0233501 |
| GLIS3 | GLIS family zinc finger 3 | -0.0224867 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.022083 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0214954 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.021409 |
| FTL | ferritin, light polypeptide | -0.021351 |
| DNER | delta/notch-like EGF repeat containing | -0.0209153 |
| SEPTIN9 | septin 9 | -0.0209063 |
| FBXO11 | F-box protein 11 | -0.0207781 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0200662 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0198243 |
| OSMR | oncostatin M receptor | -0.0195263 |
| RSU1 | Ras suppressor protein 1 | -0.0191549 |
| S100A10 | S100 calcium binding protein A10 | -0.018707 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0186674 |
| NLK | nemo-like kinase | -0.0186205 |
| NUMB | numb homolog (Drosophila) | -0.0186168 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0186089 |
| PYGL | phosphorylase, glycogen, liver | -0.0183698 |
| RPL35A | ribosomal protein L35a | -0.0180489 |
| RSRP1 | arginine/serine-rich protein 1 | -0.0175814 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0175263 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0172999 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0172708 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0172268 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.016545 |
| HPCAL1 | hippocalcin-like 1 | -0.0164289 |
| MTSS1 | metastasis suppressor 1 | -0.0164114 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0163871 |
| PSEN1 | presenilin 1 | -0.0161633 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0161306 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0160758 |
| CLIC4 | chloride intracellular channel 4 | -0.0159631 |
| PRRX1 | paired related homeobox 1 | -0.0159357 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0159122 |
| SMAD2 | SMAD family member 2 | -0.0158731 |
| BRD4 | bromodomain containing 4 | -0.0158162 |
| PCNX4 | pecanex 4 | -0.0157703 |
| IL1B | interleukin 1, beta | -0.0157315 |
| WLS | wntless Wnt ligand secretion mediator | -0.0156679 |
| POTEF | POTE ankyrin domain family, member F | -0.0155883 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.0155539 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.015508 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0154103 |
| DUSP16 | dual specificity phosphatase 16 | -0.0153855 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.015326 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0152441 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0151209 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0150808 |
| S100A6 | S100 calcium binding protein A6 | -0.0149288 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0147923 |
| IL1R1 | interleukin 1 receptor, type I | -0.014406 |
| RPS23 | ribosomal protein S23 | -0.0144004 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0142035 |
| FRMD4A | FERM domain containing 4A | -0.0142008 |
| ATF7 | activating transcription factor 7 | -0.0141875 |
| ATF4 | activating transcription factor 4 | -0.0140559 |
| RPL36 | ribosomal protein L36 | -0.0139965 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0139003 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0138995 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0137521 |
| AVIL | advillin | -0.013732 |
| RPS11 | ribosomal protein S11 | -0.0137232 |
| CDH13 | cadherin 13 | -0.0136884 |
| DCLK2 | doublecortin-like kinase 2 | -0.0134464 |
| SNX9 | sorting nexin 9 | -0.0134233 |
| GPATCH2L | G patch domain containing 2-like | -0.0133979 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0133434 |
| NABP1 | nucleic acid binding protein 1 | -0.0133286 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0133123 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0132938 |
