| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.31044 |
| GRAMD1B | GRAM domain containing 1B | 0.181923 |
| VIM | vimentin | 0.134485 |
| TXNRD1 | thioredoxin reductase 1 | 0.106497 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.103926 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.102929 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.101652 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0982423 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0916717 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0818332 |
| FGB | fibrinogen beta chain | 0.0794281 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0791608 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0771862 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0754204 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0745447 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0718104 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0709111 |
| PKM | pyruvate kinase, muscle | 0.0672292 |
| MT2A | metallothionein 2A | 0.0661124 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0661051 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.065603 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0645613 |
| RPL4 | ribosomal protein L4 | 0.0591437 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0590756 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0472845 |
| WWOX | WW domain containing oxidoreductase | 0.0471853 |
| RTN4 | reticulon 4 | 0.0470447 |
| FGG | fibrinogen gamma chain | 0.0451532 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0450555 |
| KIF5B | kinesin family member 5B | 0.0445554 |
| MKI67 | marker of proliferation Ki-67 | 0.0443528 |
| AHR | aryl hydrocarbon receptor | 0.044229 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0423277 |
| ENO1 | enolase 1, (alpha) | 0.0417129 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0416661 |
| USP3 | ubiquitin specific peptidase 3 | 0.0400282 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.038786 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0385861 |
| TPM3 | tropomyosin 3 | 0.0374364 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0372183 |
| TUBB | tubulin, beta class I | 0.037175 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0370238 |
| TMEM123 | transmembrane protein 123 | 0.0367446 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0364949 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0364309 |
| NNMT | nicotinamide N-methyltransferase | 0.036201 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0361346 |
| SP3 | Sp3 transcription factor | 0.0361277 |
| PRR16 | proline rich 16 | 0.0359112 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0346565 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0344688 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0334618 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0328307 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0327493 |
| ECT2 | epithelial cell transforming 2 | 0.0326017 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0323085 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0319163 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0317897 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0316458 |
| RPL7 | ribosomal protein L7 | 0.0314454 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0313525 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0312918 |
| BICC1 | BicC family RNA binding protein 1 | 0.031249 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0310543 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0307079 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0304403 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0304273 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0302708 |
| ANLN | anillin, actin binding protein | 0.030044 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0299828 |
| FHIT | fragile histidine triad | 0.0294047 |
| MATR3 | matrin 3 | 0.0291449 |
| LDHA | lactate dehydrogenase A | 0.028747 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0287301 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0285525 |
| SQSTM1 | sequestosome 1 | 0.0285291 |
| RRM2 | ribonucleotide reductase M2 | 0.0284164 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0282746 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0282646 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0278346 |
| ENAH | enabled homolog (Drosophila) | 0.0273035 |
| ZNF292 | zinc finger protein 292 | 0.0272687 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0272451 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.026919 |
| DST | dystonin | 0.0268233 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0265853 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 | 0.0263477 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.0262239 |
| MYOF | myoferlin | 0.0259917 |
| NRP1 | neuropilin 1 | 0.025605 |
| EFNA5 | ephrin-A5 | 0.0253101 |
| PDS5A | PDS5 cohesin associated factor A | 0.0250831 |
| GPC6 | glypican 6 | 0.0250795 |
| XPO1 | exportin 1 | 0.0249956 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.0246411 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0246311 |
| THBS1 | thrombospondin 1 | 0.0245546 |
| TNPO1 | transportin 1 | 0.024517 |
| ZFR | zinc finger RNA binding protein | 0.0244025 |
| QKI | QKI, KH domain containing, RNA binding | 0.0243797 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.144089 |
| TMSB10 | thymosin beta 10 | -0.132721 |
| KYNU | kynureninase | -0.0812402 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0772813 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0693265 |
| CMIP | c-Maf inducing protein | -0.0684 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0596287 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0579175 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0547044 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0539215 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.04949 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0462365 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0460678 |
| EGFR | epidermal growth factor receptor | -0.0441038 |
| EGR1 | early growth response 1 | -0.0436732 |
| RBM25 | RNA binding motif protein 25 | -0.0420875 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0412234 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.040729 |
| GLIS3 | GLIS family zinc finger 3 | -0.0401472 |
| DENND4A | DENN/MADD domain containing 4A | -0.0389524 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0388497 |
| PTK2 | protein tyrosine kinase 2 | -0.0382429 |
| RPL31 | ribosomal protein L31 | -0.0375076 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0352271 |
| COPA | coatomer protein complex, subunit alpha | -0.0345623 |
| RPL36 | ribosomal protein L36 | -0.0339174 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0331486 |
| FTL | ferritin, light polypeptide | -0.0330869 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.032417 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0316196 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0315534 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0307687 |
| ACTN1 | actinin, alpha 1 | -0.0306322 |
| INTS6 | integrator complex subunit 6 | -0.0304182 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0298546 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0290809 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0288291 |
| NF1 | neurofibromin 1 | -0.028752 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0280076 |
| IER3 | immediate early response 3 | -0.0278337 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0276654 |
| USP34 | ubiquitin specific peptidase 34 | -0.0276468 |
| OSMR | oncostatin M receptor | -0.0276353 |
| HLA-B | major histocompatibility complex, class I, B | -0.0269794 |
| NLK | nemo-like kinase | -0.0268548 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.026756 |
| CDK13 | cyclin-dependent kinase 13 | -0.0264946 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0263564 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0262067 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0260982 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0260969 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0258564 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0256136 |
| BRD2 | bromodomain containing 2 | -0.0254058 |
| ATF4 | activating transcription factor 4 | -0.0253971 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0253136 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0248524 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0248129 |
| WDR70 | WD repeat domain 70 | -0.0248066 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0245652 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0244662 |
| HDLBP | high density lipoprotein binding protein | -0.024389 |
| NOP58 | NOP58 ribonucleoprotein | -0.0241458 |
| CTBP2 | C-terminal binding protein 2 | -0.0240668 |
| SETD5 | SET domain containing 5 | -0.0240634 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0236629 |
| DYM | dymeclin | -0.0236549 |
| FLNB | filamin B, beta | -0.0236471 |
| RCC1 | regulator of chromosome condensation 1 | -0.0236276 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0234899 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0234739 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0233528 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0232882 |
| RPS19 | ribosomal protein S19 | -0.0229985 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0228737 |
| CUX1 | cut-like homeobox 1 | -0.0227574 |
| TOP1 | topoisomerase (DNA) I | -0.0227509 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0227506 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0225587 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0225578 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0219886 |
| INO80 | INO80 complex subunit | -0.0219587 |
| ZNF207 | zinc finger protein 207 | -0.0218881 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0216992 |
| EHBP1 | EH domain binding protein 1 | -0.0216216 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0216166 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0213073 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0212107 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0211718 |
| MEF2D | myocyte enhancer factor 2D | -0.0208328 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0207955 |
| TBCA | tubulin folding cofactor A | -0.0205778 |
| EXOC6B | exocyst complex component 6B | -0.0205695 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0203862 |
| GPATCH2L | G patch domain containing 2-like | -0.0203772 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0203109 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0203027 |
| ZNF609 | zinc finger protein 609 | -0.0202961 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0202952 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0202939 |
