Simotinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Simotinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Simotinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.225337
VIM vimentin 0.149068
FN1 fibronectin 1 0.108565
FTL ferritin, light polypeptide 0.106279
AKAP12 A kinase (PRKA) anchor protein 12 0.0835702
MT2A metallothionein 2A 0.075892
PTMA prothymosin, alpha 0.0727217
TMSB10 thymosin beta 10 0.068911
RPL35A ribosomal protein L35a 0.0674493
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0651533
RPL23 ribosomal protein L23 0.0622885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0619018
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0611693
BIRC6 baculoviral IAP repeat containing 6 0.0539572
POTEF POTE ankyrin domain family, member F 0.0511352
RPS16 ribosomal protein S16 0.0493967
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0487391
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0474106
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0464629
PRRC2C proline-rich coiled-coil 2C 0.0456938
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0421758
ASPH aspartate beta-hydroxylase 0.0408581
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0405758
RPS8 ribosomal protein S8 0.0401411
EIF1 eukaryotic translation initiation factor 1 0.0399415
NAMPT nicotinamide phosphoribosyltransferase 0.0368987
RPL19 ribosomal protein L19 0.036274
RPS23 ribosomal protein S23 0.0358204
RPLP1 ribosomal protein, large, P1 0.0351196
SND1 staphylococcal nuclease and tudor domain containing 1 0.0346239
RPS6 ribosomal protein S6 0.0344902
MYO10 myosin X 0.0336343
VMP1 vacuole membrane protein 1 0.0335885
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.033229
RPS3 ribosomal protein S3 0.0332073
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0330906
ADNP activity-dependent neuroprotector homeobox 0.033071
RPLP2 ribosomal protein, large, P2 0.0321078
VDAC1 voltage-dependent anion channel 1 0.0314696
SEPTIN7 septin 7 0.0310831
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0309973
SETD5 SET domain containing 5 0.0304995
RPL11 ribosomal protein L11 0.0300112
GOLGA4 golgin A4 0.0297572
RPL12 ribosomal protein L12 0.0293505
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0290379
RPL31 ribosomal protein L31 0.0287046
STAU1 staufen double-stranded RNA binding protein 1 0.0286667
LOC112694756 uncharaterized LOC112694756 0.0283807
KMT2E lysine (K)-specific methyltransferase 2E 0.0277651
GPC6 glypican 6 0.027492
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0274421
HDLBP high density lipoprotein binding protein 0.0265066
ANXA2 annexin A2 0.0263658
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0255325
RPL8 ribosomal protein L8 0.0253933
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.025322
ATM ATM serine/threonine kinase 0.0252999
TOP1 topoisomerase (DNA) I 0.0252831
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0251868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0249257
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0248349
SBF2 SET binding factor 2 0.024631
YBX1 Y box binding protein 1 0.0242382
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0239688
KDM2A lysine (K)-specific demethylase 2A 0.02388
TM4SF1 transmembrane 4 L six family member 1 0.0238698
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0238043
CALR calreticulin 0.0235792
ANKHD1 ankyrin repeat and KH domain containing 1 0.0229605
CALU calumenin 0.0229034
ARF1 ADP-ribosylation factor 1 0.0222649
ACBD3 acyl-CoA binding domain containing 3 0.0220321
FUS FUS RNA binding protein 0.0220063
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0219212
ACTG1 actin gamma 1 0.0216777
EIF4A1 eukaryotic translation initiation factor 4A1 0.021656
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0214509
MATR3 matrin 3 0.0213913
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0208759
FBL fibrillarin 0.0207215
RPL26 ribosomal protein L26 0.0205204
MBNL1 muscleblind-like splicing regulator 1 0.0199755
S100A6 S100 calcium binding protein A6 0.0199398
DDIT4 DNA-damage-inducible transcript 4 0.0199349
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0197201
IFI16 interferon, gamma-inducible protein 16 0.0195365
TPT1 tumor protein, translationally-controlled 1 0.0190262
DLG1 discs, large homolog 1 (Drosophila) 0.0190195
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0189244
OLA1 Obg-like ATPase 1 0.0186046
ELL2 elongation factor, RNA polymerase II, 2 0.0185782
LMAN1 lectin, mannose-binding, 1 0.0183431
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0181567
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0178837
CCNI cyclin I 0.0175952
RPL36 ribosomal protein L36 0.0174727
NLGN1 neuroligin 1 0.0174651
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0173822
MARCHF6 membrane associated ring-CH-type finger 6 0.0173415

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.113205
BACE2 beta-site APP-cleaving enzyme 2 -0.103835
GRB10 growth factor receptor-bound protein 10 -0.103424
MUC16 mucin 16, cell surface associated -0.0985284
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0896109
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0799045
IGF1R insulin-like growth factor 1 receptor -0.0668332
PDE4D phosphodiesterase 4D, cAMP-specific -0.0664459
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0655236
IGF2 insulin-like growth factor 2 -0.0649822
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0641485
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0619388
LMO7 LIM domain 7 -0.0606848
IFIH1 interferon induced with helicase C domain 1 -0.0588053
OGA O-GlcNAcase -0.0563219
CEMIP cell migration inducing protein, hyaluronan binding -0.0554078
MYO5B myosin VB -0.0552373
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0548623
KRT17 keratin 17, type I -0.0526214
AKAP13 A kinase (PRKA) anchor protein 13 -0.0520846
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0512704
RAB1A RAB1A, member RAS oncogene family -0.0509306
PTPRM protein tyrosine phosphatase, receptor type, M -0.0500942
RAB8B RAB8B, member RAS oncogene family -0.0489473
NEK7 NIMA-related kinase 7 -0.0486556
TJP1 tight junction protein 1 -0.0483801
PERP PERP, TP53 apoptosis effector -0.0481511
F3 coagulation factor III (thromboplastin, tissue factor) -0.0472336
ABHD17C abhydrolase domain containing 17C -0.0462376
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0454405
PELI1 pellino E3 ubiquitin protein ligase 1 -0.044715
ATOSA atos homolog A -0.0445296
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0444952
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0438401
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0434158
JUP junction plakoglobin -0.042842
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0422094
MACF1 microtubule-actin crosslinking factor 1 -0.0407903
TNIP1 TNFAIP3 interacting protein 1 -0.0407019
LPP LIM domain containing preferred translocation partner in lipoma -0.0403004
MYO1E myosin IE -0.0394509
KDM6A lysine (K)-specific demethylase 6A -0.0390906
KYNU kynureninase -0.0385734
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0381334
SAMD4A sterile alpha motif domain containing 4A -0.0379243
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0378941
SMOC1 SPARC related modular calcium binding 1 -0.0378812
MEF2A myocyte enhancer factor 2A -0.0370631
BMAL2 basic helix-loop-helix ARNT like 2 -0.0369493
ATXN1 ataxin 1 -0.0363889
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0358666
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0355671
SP100 SP100 nuclear antigen -0.0349063
SVIL supervillin -0.0348113
PICALM phosphatidylinositol binding clathrin assembly protein -0.0341963
RBM47 RNA binding motif protein 47 -0.0339974
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0339438
USP9X ubiquitin specific peptidase 9, X-linked -0.0338693
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0337703
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0334488
FOXO3 forkhead box O3 -0.033396
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0332344
PHF3 PHD finger protein 3 -0.032922
MED13 mediator complex subunit 13 -0.0325175
KMT2C lysine (K)-specific methyltransferase 2C -0.0324499
NPTN neuroplastin -0.0323052
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0321767
CFDP1 craniofacial development protein 1 -0.0321417
FNDC3A fibronectin type III domain containing 3A -0.0318451
SSBP2 single-stranded DNA binding protein 2 -0.0316877
ZNF292 zinc finger protein 292 -0.0314905
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0314608
ABLIM1 actin binding LIM protein 1 -0.0311092
MXD1 MAX dimerization protein 1 -0.0301846
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.029944
NDRG1 N-myc downstream regulated 1 -0.0293864
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0290745
OSBPL10 oxysterol binding protein-like 10 -0.0277957
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0274274
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0274106
NCOR2 nuclear receptor corepressor 2 -0.0270968
ESYT2 extended synaptotagmin-like protein 2 -0.0269482
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0262885
RND3 Rho family GTPase 3 -0.0256141
LIMCH1 LIM and calponin homology domains 1 -0.0255916
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0252926
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0252926
ZMYM2 zinc finger, MYM-type 2 -0.0251202
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0250398
UGCG UDP-glucose ceramide glucosyltransferase -0.0248906
ANKRD10 ankyrin repeat domain 10 -0.0248677
LCORL ligand dependent nuclear receptor corepressor-like -0.0245788
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0245357
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0244461
STRN3 striatin, calmodulin binding protein 3 -0.0238512
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0233277
FAM13A family with sequence similarity 13, member A -0.023153
MED13L mediator complex subunit 13-like -0.0225839
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0225296
CUX1 cut-like homeobox 1 -0.0223457