| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.136618 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.133737 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.120339 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0952569 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0943872 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0883331 |
| RAD51B | RAD51 paralog B | 0.0792159 |
| TPI1 | triosephosphate isomerase 1 | 0.0780968 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0739565 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.073931 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0689328 |
| PHIP | pleckstrin homology domain interacting protein | 0.0538368 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0496704 |
| BBX | bobby sox homolog (Drosophila) | 0.0486398 |
| RTN4 | reticulon 4 | 0.0480943 |
| RPL35A | ribosomal protein L35a | 0.046975 |
| RPS8 | ribosomal protein S8 | 0.0466505 |
| RPLP0 | ribosomal protein, large, P0 | 0.0464942 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.045909 |
| MT2A | metallothionein 2A | 0.0440101 |
| LDHB | lactate dehydrogenase B | 0.0439697 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0435114 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0419854 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0395114 |
| PGK1 | phosphoglycerate kinase 1 | 0.0384874 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0384857 |
| CBX3 | chromobox homolog 3 | 0.0377551 |
| MIS18BP1 | MIS18 binding protein 1 | 0.037464 |
| RPS21 | ribosomal protein S21 | 0.0373985 |
| TMSB10 | thymosin beta 10 | 0.035222 |
| MORF4L2 | mortality factor 4 like 2 | 0.0348863 |
| RPS6 | ribosomal protein S6 | 0.0341758 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0337842 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0337634 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0326961 |
| CENPF | centromere protein F, 350/400kDa | 0.0325616 |
| RPL12 | ribosomal protein L12 | 0.0316076 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0314279 |
| RPS19 | ribosomal protein S19 | 0.0308639 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0301539 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0300232 |
| HMGA1 | high mobility group AT-hook 1 | 0.0299613 |
| VIM | vimentin | 0.0296102 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0293568 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0291757 |
| RPL11 | ribosomal protein L11 | 0.0291725 |
| CCDC88A | coiled-coil domain containing 88A | 0.0289781 |
| DIAPH3 | diaphanous-related formin 3 | 0.0287682 |
| RPL32 | ribosomal protein L32 | 0.0279326 |
| RPS4X | ribosomal protein S4, X-linked | 0.0278641 |
| SET | SET nuclear proto-oncogene | 0.0277322 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0276327 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.02743 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0268549 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0268306 |
| GLO1 | glyoxalase I | 0.0267905 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0267818 |
| RPL5 | ribosomal protein L5 | 0.0267029 |
| RPLP1 | ribosomal protein, large, P1 | 0.026582 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0264547 |
| RPS29 | ribosomal protein S29 | 0.0262453 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0259247 |
| RPL8 | ribosomal protein L8 | 0.0253971 |
| KRT18 | keratin 18, type I | 0.0253346 |
| RPS27 | ribosomal protein S27 | 0.0253073 |
| ANLN | anillin, actin binding protein | 0.0251572 |
| CEP192 | centrosomal protein 192kDa | 0.0250092 |
| ZNF292 | zinc finger protein 292 | 0.0249655 |
| PFDN2 | prefoldin subunit 2 | 0.0249453 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0247815 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0245901 |
| RPS15 | ribosomal protein S15 | 0.0244906 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0243415 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0243287 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0243107 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0240638 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | 0.0237781 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0236621 |
| PLCB4 | phospholipase C, beta 4 | 0.0234065 |
| PCM1 | pericentriolar material 1 | 0.0234056 |
| RPL19 | ribosomal protein L19 | 0.0230155 |
| MKI67 | marker of proliferation Ki-67 | 0.0227699 |
| RPL7 | ribosomal protein L7 | 0.0226291 |
| SGO2 | shugoshin 2 | 0.0225 |
| NABP1 | nucleic acid binding protein 1 | 0.0224418 |
| TMEM165 | transmembrane protein 165 | 0.022406 |
| RRM2 | ribonucleotide reductase M2 | 0.0220665 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.022009 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0218552 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.021568 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.021548 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0214314 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0213785 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0213482 |
| EXOC6B | exocyst complex component 6B | 0.0213343 |
| ANKRD36 | ankyrin repeat domain 36 | 0.021256 |
| GOLGA4 | golgin A4 | 0.0211073 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0210822 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0209236 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0208943 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.472794 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.137531 |
| OSMR | oncostatin M receptor | -0.0851704 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0723489 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0682935 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0605084 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0593444 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0575164 |
| MCL1 | myeloid cell leukemia 1 | -0.0546661 |
| UBC | ubiquitin C | -0.0530967 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0525232 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0485211 |
| TPM4 | tropomyosin 4 | -0.0481458 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0475532 |
| HMGA2 | high mobility group AT-hook 2 | -0.0471656 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0454548 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0449934 |
| HLA-B | major histocompatibility complex, class I, B | -0.0405529 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0382876 |
| TPM3 | tropomyosin 3 | -0.0377808 |
| PDE10A | phosphodiesterase 10A | -0.0376965 |
| NF1 | neurofibromin 1 | -0.0368828 |
| IER3 | immediate early response 3 | -0.0367591 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0350133 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0345088 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0340449 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0336894 |
| PYGL | phosphorylase, glycogen, liver | -0.033435 |
| AHNAK | AHNAK nucleoprotein | -0.0322982 |
| RYR3 | ryanodine receptor 3 | -0.0320298 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.031502 |
| CUX1 | cut-like homeobox 1 | -0.0312387 |
| USP34 | ubiquitin specific peptidase 34 | -0.0311842 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0303256 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0300084 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0295772 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.029544 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0290802 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0290269 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0287398 |
| AEBP2 | AE binding protein 2 | -0.0285058 |
| CDK12 | cyclin-dependent kinase 12 | -0.0280434 |
| BPTF | bromodomain PHD finger transcription factor | -0.0278877 |
| RNF213 | ring finger protein 213 | -0.0273046 |
| CAVIN1 | caveolae associated protein 1 | -0.0272295 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0271336 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0261792 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0261763 |
| VMP1 | vacuole membrane protein 1 | -0.0258721 |
| PTK2 | protein tyrosine kinase 2 | -0.0256097 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0255546 |
| MAP4 | microtubule-associated protein 4 | -0.025483 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0253805 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0252042 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0251624 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0251217 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.025089 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0249976 |
| CTTN | cortactin | -0.0249544 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0247744 |
| ATG7 | autophagy related 7 | -0.0247725 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0245389 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0245168 |
| VCL | vinculin | -0.0244866 |
| GPATCH8 | G patch domain containing 8 | -0.0242078 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0241165 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0240309 |
| EPAS1 | endothelial PAS domain protein 1 | -0.023654 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.023363 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0233392 |
| ACTN1 | actinin, alpha 1 | -0.0232262 |
| SVIL | supervillin | -0.0224111 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0221934 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0221576 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0218085 |
| ETV6 | ets variant 6 | -0.0216455 |
| TAOK1 | TAO kinase 1 | -0.0207803 |
| TAPBP | TAP binding protein (tapasin) | -0.020745 |
| RPS27A | ribosomal protein S27a | -0.0207301 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0205529 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0205485 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0202531 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0199747 |
| VCP | valosin containing protein | -0.0196977 |
| APP | amyloid beta (A4) precursor protein | -0.0195488 |
| INTS6 | integrator complex subunit 6 | -0.0194975 |
| PLEC | plectin | -0.0194369 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0194157 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0193219 |
| SETX | senataxin | -0.0192537 |
| EGFR | epidermal growth factor receptor | -0.0191105 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0189667 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0189044 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0186906 |
| CALR | calreticulin | -0.0186596 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0186579 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0186139 |
| STC1 | stanniocalcin 1 | -0.0184007 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0183736 |
| CDK17 | cyclin-dependent kinase 17 | -0.0180801 |
