| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL35A | ribosomal protein L35a | 0.10186 |
| LAMB3 | laminin, beta 3 | 0.0916888 |
| NDRG1 | N-myc downstream regulated 1 | 0.0769082 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0721102 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0706754 |
| MT2A | metallothionein 2A | 0.0693209 |
| EFNA5 | ephrin-A5 | 0.0687426 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0674369 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0662155 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0661922 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0656977 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0624134 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0615729 |
| RPL34 | ribosomal protein L34 | 0.0602145 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0586766 |
| FHIT | fragile histidine triad | 0.0565162 |
| PGK1 | phosphoglycerate kinase 1 | 0.0554878 |
| RPS6 | ribosomal protein S6 | 0.0539956 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0535819 |
| RPLP0 | ribosomal protein, large, P0 | 0.0509359 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0501029 |
| RPL30 | ribosomal protein L30 | 0.0494786 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0468291 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0450877 |
| RPL11 | ribosomal protein L11 | 0.0446374 |
| UPP1 | uridine phosphorylase 1 | 0.0445249 |
| RPS19 | ribosomal protein S19 | 0.0422114 |
| RAD51B | RAD51 paralog B | 0.0414573 |
| RPLP1 | ribosomal protein, large, P1 | 0.0408628 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0405905 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.039926 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0390279 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0379773 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0373532 |
| RPL9 | ribosomal protein L9 | 0.0372006 |
| RPL7 | ribosomal protein L7 | 0.0370832 |
| RPS13 | ribosomal protein S13 | 0.0369579 |
| NAV2 | neuron navigator 2 | 0.0366006 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0362562 |
| CSTB | cystatin B (stefin B) | 0.0357623 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0350089 |
| RPL37 | ribosomal protein L37 | 0.034705 |
| ACTG1 | actin gamma 1 | 0.0338544 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0336038 |
| FAM13A | family with sequence similarity 13, member A | 0.0335193 |
| RPS29 | ribosomal protein S29 | 0.0331744 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0325309 |
| CAB39 | calcium binding protein 39 | 0.0318336 |
| RPS20 | ribosomal protein S20 | 0.03117 |
| RUNX1 | runt-related transcription factor 1 | 0.0311281 |
| RPS8 | ribosomal protein S8 | 0.0309985 |
| PRELID2 | PRELI domain containing 2 | 0.0307487 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0302912 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0301089 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0297023 |
| RPL23 | ribosomal protein L23 | 0.0295554 |
| RPS16 | ribosomal protein S16 | 0.0293785 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.029206 |
| RPL27 | ribosomal protein L27 | 0.0289295 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.028756 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0285786 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0285501 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0284318 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0281394 |
| RPS21 | ribosomal protein S21 | 0.0278866 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0278211 |
| CTSB | cathepsin B | 0.0277747 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0272261 |
| RPL29 | ribosomal protein L29 | 0.027087 |
| RPL4 | ribosomal protein L4 | 0.0269899 |
| STEAP4 | STEAP family member 4 | 0.0266709 |
| RPS4X | ribosomal protein S4, X-linked | 0.0266489 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0265395 |
| RPL37A | ribosomal protein L37a | 0.0262927 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0262585 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0256925 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.024321 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0241199 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0233678 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.023304 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0231856 |
| RPS27 | ribosomal protein S27 | 0.0229008 |
| RPL12 | ribosomal protein L12 | 0.0227585 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.022409 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.022269 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0221567 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.022065 |
| CDC73 | cell division cycle 73 | 0.0219826 |
| MEF2A | myocyte enhancer factor 2A | 0.0218261 |
| EFHD2 | EF-hand domain family, member D2 | 0.0214818 |
| FAM3C | family with sequence similarity 3, member C | 0.0210955 |
| TRAF3 | TNF receptor-associated factor 3 | 0.0210462 |
| PRKCA | protein kinase C, alpha | 0.0209591 |
| SMYD3 | SET and MYND domain containing 3 | 0.0208458 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0206709 |
| DTNA | dystrobrevin, alpha | 0.0206233 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.02051 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0204822 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0202882 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0202389 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.220306 |
| PTMA | prothymosin, alpha | -0.189035 |
| POTEF | POTE ankyrin domain family, member F | -0.167695 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.147136 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144305 |
| CALR | calreticulin | -0.0921268 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0746439 |
| ASPH | aspartate beta-hydroxylase | -0.0672789 |
| FN1 | fibronectin 1 | -0.0671187 |
| RPS27A | ribosomal protein S27a | -0.0630844 |
| TPM4 | tropomyosin 4 | -0.0630118 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0614447 |
| CANX | calnexin | -0.059656 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0588661 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0578696 |
| YBX1 | Y box binding protein 1 | -0.0578646 |
| TPM3 | tropomyosin 3 | -0.0514266 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0513348 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0503853 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0494849 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0494024 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0489025 |
| VEGFA | vascular endothelial growth factor A | -0.0485344 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0482929 |
| COPA | coatomer protein complex, subunit alpha | -0.0481842 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0476801 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0464461 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.0460102 |
| ZNF207 | zinc finger protein 207 | -0.0445104 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0436372 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0434141 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0417644 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0407566 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0402169 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0396916 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0388757 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0388092 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0385066 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0382567 |
| AHNAK | AHNAK nucleoprotein | -0.0381073 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0380034 |
| PLEC | plectin | -0.0379198 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0378538 |
| ERBIN | erbb2 interacting protein | -0.0373792 |
| MYO6 | myosin VI | -0.0372692 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0362715 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0360259 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.035895 |
| HDLBP | high density lipoprotein binding protein | -0.035414 |
| WASF2 | WAS protein family, member 2 | -0.0352873 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.035096 |
| RLF | rearranged L-myc fusion | -0.0349529 |
| SPAG9 | sperm associated antigen 9 | -0.034339 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0342899 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0342087 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0323545 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0311289 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0310816 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0309397 |
| PCBP2 | poly(rC) binding protein 2 | -0.0306498 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0304891 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0304729 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0304194 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.030264 |
| RHEB | Ras homolog enriched in brain | -0.0302383 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0301864 |
| SDC4 | syndecan 4 | -0.0298805 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0294128 |
| CALU | calumenin | -0.0294087 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0293962 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0291512 |
| NOP58 | NOP58 ribonucleoprotein | -0.0289844 |
| VIM | vimentin | -0.0289441 |
| HMGB2 | high mobility group box 2 | -0.028858 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0282137 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0280343 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0280088 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0279905 |
| DIAPH1 | diaphanous-related formin 1 | -0.0279482 |
| RHOA | ras homolog family member A | -0.0274905 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0274363 |
| JUN | jun proto-oncogene | -0.0272591 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0267716 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.026702 |
| RBM5 | RNA binding motif protein 5 | -0.0265565 |
| TXNIP | thioredoxin interacting protein | -0.0264752 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0262305 |
| MCU | mitochondrial calcium uniporter | -0.026043 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0260315 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0257291 |
| BRD2 | bromodomain containing 2 | -0.0254141 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0253917 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0253475 |
| RBM25 | RNA binding motif protein 25 | -0.0252093 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.0250908 |
| RYBP | RING1 and YY1 binding protein | -0.0250059 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0249682 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0248995 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0248267 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0246939 |
