| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.16582 |
| EFNA5 | ephrin-A5 | 0.116814 |
| PDE10A | phosphodiesterase 10A | 0.111992 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.105089 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0840863 |
| GRAMD1B | GRAM domain containing 1B | 0.0838803 |
| GDA | guanine deaminase | 0.072612 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0685547 |
| NRCAM | neuronal cell adhesion molecule | 0.0662588 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0621013 |
| MYOF | myoferlin | 0.0611893 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0598603 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0594286 |
| MCL1 | myeloid cell leukemia 1 | 0.0572259 |
| COL5A2 | collagen, type V, alpha 2 | 0.0542107 |
| RPS6 | ribosomal protein S6 | 0.0541525 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0530186 |
| KYNU | kynureninase | 0.0527499 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0520158 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0490813 |
| MT2A | metallothionein 2A | 0.0489399 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0486481 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0469959 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0451065 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0446618 |
| DST | dystonin | 0.0430438 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0424856 |
| POTEF | POTE ankyrin domain family, member F | 0.041728 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0406453 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0406112 |
| PCBP2 | poly(rC) binding protein 2 | 0.0393974 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0389664 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0380862 |
| MFF | mitochondrial fission factor | 0.0379351 |
| CTSC | cathepsin C | 0.0363374 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0359297 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0359189 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0350141 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0349162 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0348749 |
| MSN | moesin | 0.0343873 |
| ASPH | aspartate beta-hydroxylase | 0.0339759 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0339245 |
| TXNRD1 | thioredoxin reductase 1 | 0.0337803 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.032397 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0321615 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0320528 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0317883 |
| PYGL | phosphorylase, glycogen, liver | 0.0311118 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0310646 |
| SET | SET nuclear proto-oncogene | 0.030737 |
| PKM | pyruvate kinase, muscle | 0.0305127 |
| FLNB | filamin B, beta | 0.030373 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0300654 |
| TMSB10 | thymosin beta 10 | 0.0297814 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0296942 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0294455 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0294088 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0291837 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0287884 |
| PCBP3 | poly(rC) binding protein 3 | 0.0287745 |
| CENPF | centromere protein F, 350/400kDa | 0.0285239 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.02826 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0281069 |
| B2M | beta-2-microglobulin | 0.02769 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0274969 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0264767 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0263603 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0261893 |
| RPL37A | ribosomal protein L37a | 0.0260682 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0248723 |
| CD109 | CD109 molecule | 0.0244997 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0244932 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0242147 |
| PTGR1 | prostaglandin reductase 1 | 0.0237385 |
| PTEN | phosphatase and tensin homolog | 0.0235626 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0234047 |
| CTSL | cathepsin L | 0.0230324 |
| RPS19 | ribosomal protein S19 | 0.0229963 |
| RPL7 | ribosomal protein L7 | 0.0229953 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0222125 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0221332 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0220069 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0219823 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0215816 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0215013 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0212121 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0210407 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0210126 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0205772 |
| TBXT | T-box transcription factor T | 0.0205442 |
| ENO1 | enolase 1, (alpha) | 0.0204537 |
| DOCK4 | dedicator of cytokinesis 4 | 0.020348 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0202069 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0201491 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0200033 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0199098 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0198286 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.019773 |
| RPS8 | ribosomal protein S8 | 0.0197104 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.273265 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.183115 |
| FN1 | fibronectin 1 | -0.0922715 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0737281 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0662435 |
| CANX | calnexin | -0.0575031 |
| PTMA | prothymosin, alpha | -0.0543272 |
| SPAG9 | sperm associated antigen 9 | -0.048351 |
| RPS24 | ribosomal protein S24 | -0.0428745 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0407226 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0372431 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0364461 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0343855 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0343489 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0326087 |
| OGA | O-GlcNAcase | -0.0307364 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0293184 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0266612 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0258689 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0243699 |
| USP3 | ubiquitin specific peptidase 3 | -0.0242344 |
| CALR | calreticulin | -0.0235109 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0232493 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0229819 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0216803 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0216376 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0210347 |
| ANXA1 | annexin A1 | -0.0200906 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0199611 |
| ARF1 | ADP-ribosylation factor 1 | -0.0198967 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0198817 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0192188 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0185413 |
| AHNAK | AHNAK nucleoprotein | -0.0185161 |
| S100A10 | S100 calcium binding protein A10 | -0.0168833 |
| WDR45B | WD repeat domain 45B | -0.0166074 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0161743 |
| RBM39 | RNA binding motif protein 39 | -0.016045 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0159524 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0155398 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0153888 |
| HBP1 | HMG-box transcription factor 1 | -0.0153132 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0148956 |
| RHOB | ras homolog family member B | -0.0148209 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.014727 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0139331 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0138848 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0137207 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0135577 |
| RLF | rearranged L-myc fusion | -0.0133424 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0133031 |
| MORF4L2 | mortality factor 4 like 2 | -0.0132763 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0131637 |
| ATF3 | activating transcription factor 3 | -0.0130895 |
| TAOK1 | TAO kinase 1 | -0.0130406 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0129461 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0129444 |
| SRP72 | signal recognition particle 72kDa | -0.0128261 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0128132 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0127928 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0127022 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0126754 |
| HDLBP | high density lipoprotein binding protein | -0.0126462 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0126411 |
| YBX1 | Y box binding protein 1 | -0.0124498 |
| RPL6 | ribosomal protein L6 | -0.0122635 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0121688 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.012159 |
| HYOU1 | hypoxia up-regulated 1 | -0.0121045 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0120051 |
| LMO7 | LIM domain 7 | -0.0117987 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.0117642 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0117357 |
| TFRC | transferrin receptor | -0.0116606 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0116361 |
| IER3 | immediate early response 3 | -0.0115491 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0115183 |
| WTAP | Wilms tumor 1 associated protein | -0.0113487 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0112746 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0111571 |
| ANXA2 | annexin A2 | -0.0111293 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0111131 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0111038 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0110034 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0110024 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0109727 |
| CCDC47 | coiled-coil domain containing 47 | -0.0109609 |
| CUX1 | cut-like homeobox 1 | -0.0109469 |
| MORF4L1 | mortality factor 4 like 1 | -0.0109421 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0108972 |
| HDAC3 | histone deacetylase 3 | -0.0108968 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0108566 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0108094 |
| H1-0 | H1.0 linker histone | -0.0107787 |
| KLF6 | Kruppel-like factor 6 | -0.0107082 |
| UBAP2L | ubiquitin associated protein 2-like | -0.01054 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0105209 |
| ABLIM1 | actin binding LIM protein 1 | -0.0104646 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0104385 |
| CDH13 | cadherin 13 | -0.0103933 |
