Simotinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Simotinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

143 genes differentially expressed following the Simotinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NEBL nebulette 0.242893
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.161136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.114317
RHOBTB3 Rho-related BTB domain containing 3 0.11021
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104341
GOLGA4 golgin A4 0.103313
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.100816
SLIT2 slit homolog 2 (Drosophila) 0.0968525
NDRG1 N-myc downstream regulated 1 0.0920182
WDPCP WD repeat containing planar cell polarity effector 0.0857367
RAD51B RAD51 paralog B 0.0857347
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0841817
EXT1 exostosin glycosyltransferase 1 0.0772891
RPS19 ribosomal protein S19 0.0757753
ENO1 enolase 1, (alpha) 0.0668901
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0666942
CANX calnexin 0.0663664
MED13 mediator complex subunit 13 0.0646874
METTL15 methyltransferase like 15 0.0641069
CD44 CD44 molecule (Indian blood group) 0.055748
EHBP1 EH domain binding protein 1 0.0495202
NF1 neurofibromin 1 0.0485492
PNISR PNN-interacting serine/arginine-rich protein 0.0476873
TRA2A transformer 2 alpha homolog (Drosophila) 0.0466319
NCOR1 nuclear receptor corepressor 1 0.0460182
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0450462
RPL30 ribosomal protein L30 0.04371
BTBD9 BTB (POZ) domain containing 9 0.043238
TMCC1 transmembrane and coiled-coil domain family 1 0.0416806
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0402549
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0379803
RUNX1 runt-related transcription factor 1 0.0374449
MT2A metallothionein 2A 0.0363714
PDE10A phosphodiesterase 10A 0.0353762
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.032156
NALF1 NALCN channel auxiliary factor 1 0.0295137
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0269479
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0250763
VIM vimentin 0.0248538
LDHA lactate dehydrogenase A 0.0248112
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0239903
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0239023
CHD1 chromodomain helicase DNA binding protein 1 0.0238035
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0232791
BCLAF1 BCL2-associated transcription factor 1 0.0221983
LIMS1 LIM and senescent cell antigen-like domains 1 0.0214484
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0213705
RPL37A ribosomal protein L37a 0.0211098
NRG1 neuregulin 1 0.0199343
TPR translocated promoter region, nuclear basket protein 0.0195154
ZMYND8 zinc finger, MYND-type containing 8 0.0180893
VMP1 vacuole membrane protein 1 0.0163549
FAM13A family with sequence similarity 13, member A 0.0158719
KMT2E lysine (K)-specific methyltransferase 2E 0.014848
PHIP pleckstrin homology domain interacting protein 0.0145695
TMSB10 thymosin beta 10 0.0141638
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0134359
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.010398
RPL11 ribosomal protein L11 0.00960276
RORA RAR-related orphan receptor A 0.00958943
RLF rearranged L-myc fusion 0.00889187
SETD5 SET domain containing 5 0.00642633
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.00598021
GPC6 glypican 6 0.00592421
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.00406602
RPS6 ribosomal protein S6 0.00383395
EIF1 eukaryotic translation initiation factor 1 8.15873E-4

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.209438
EGFR epidermal growth factor receptor -0.173388
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.172517
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.152994
LRP1B low density lipoprotein receptor-related protein 1B -0.152175
ASPH aspartate beta-hydroxylase -0.13295
MAML3 mastermind-like 3 (Drosophila) -0.125056
NAMPT nicotinamide phosphoribosyltransferase -0.108961
WAC WW domain containing adaptor with coiled-coil -0.105038
PTMA prothymosin, alpha -0.102024
ANXA2 annexin A2 -0.0953912
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0861347
KMT2C lysine (K)-specific methyltransferase 2C -0.0857196
ZNF292 zinc finger protein 292 -0.0846946
PARD3 par-3 family cell polarity regulator -0.0820002
PTK2 protein tyrosine kinase 2 -0.0815611
RPS27A ribosomal protein S27a -0.0810771
NUP58 nucleoporin 58 -0.0797751
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0793086
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0784181
RTN4 reticulon 4 -0.0747225
UBC ubiquitin C -0.0740354
PGK1 phosphoglycerate kinase 1 -0.0738156
IGF2 insulin-like growth factor 2 -0.0730375
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0704075
RAB10 RAB10, member RAS oncogene family -0.0661023
PSD3 pleckstrin and Sec7 domain containing 3 -0.0627099
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0611805
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0537259
PKM pyruvate kinase, muscle -0.0497963
SRPK2 SRSF protein kinase 2 -0.0491935
FMNL2 formin-like 2 -0.0465871
RPS3 ribosomal protein S3 -0.0458967
SMYD3 SET and MYND domain containing 3 -0.0447002
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0438465
PRKCA protein kinase C, alpha -0.0417842
RPL31 ribosomal protein L31 -0.0403335
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0367843
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0352964
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0351602
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0350039
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0337902
EEF2 eukaryotic translation elongation factor 2 -0.0337005
DST dystonin -0.0307944
FNDC3B fibronectin type III domain containing 3B -0.0307563
TRIO trio Rho guanine nucleotide exchange factor -0.0282587
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0281885
ACTN4 actinin, alpha 4 -0.0279169
TPT1 tumor protein, translationally-controlled 1 -0.0277525
EFNA5 ephrin-A5 -0.0260152
RPL23 ribosomal protein L23 -0.025803
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0257278
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0238717
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0211942
ADAM10 ADAM metallopeptidase domain 10 -0.0205448
SBF2 SET binding factor 2 -0.0186597
CCNI cyclin I -0.0167592
FN1 fibronectin 1 -0.0166179
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0143049
FTL ferritin, light polypeptide -0.0138679
PDE4D phosphodiesterase 4D, cAMP-specific -0.0136606
TENM3 teneurin transmembrane protein 3 -0.0114621
ANKRD11 ankyrin repeat domain 11 -0.0108219
ARID1B AT rich interactive domain 1B (SWI1-like) -0.00938849
BBX bobby sox homolog (Drosophila) -0.00908306
MYH9 myosin, heavy chain 9, non-muscle -0.00852554
JMJD1C jumonji domain containing 1C -0.00773746
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00605053
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00597919
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00563895
ZBTB20 zinc finger and BTB domain containing 20 -0.00360808
MATR3 matrin 3 -0.00349294
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.00226812
GBE1 glucan (1,4-alpha-), branching enzyme 1 -8.32878E-4
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -8.15056E-4
N4BP2L2 NEDD4 binding protein 2-like 2 -3.00358E-4