| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.163917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.146493 |
| VIM | vimentin | 0.122803 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.121868 |
| TMSB10 | thymosin beta 10 | 0.0874628 |
| HDAC9 | histone deacetylase 9 | 0.0819727 |
| PHIP | pleckstrin homology domain interacting protein | 0.0752324 |
| ZNF292 | zinc finger protein 292 | 0.0746846 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0713899 |
| TSC22D2 | TSC22 domain family, member 2 | 0.069508 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0674275 |
| PFN1 | profilin 1 | 0.0665496 |
| GNAS | GNAS complex locus | 0.0641312 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0635802 |
| RPS6 | ribosomal protein S6 | 0.0633421 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0622018 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0616035 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0607867 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0594126 |
| PEG10 | paternally expressed 10 | 0.0592356 |
| COL5A2 | collagen, type V, alpha 2 | 0.0591871 |
| TENM3 | teneurin transmembrane protein 3 | 0.0581912 |
| PGK1 | phosphoglycerate kinase 1 | 0.0579848 |
| RPS16 | ribosomal protein S16 | 0.057158 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0560489 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0553128 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0545026 |
| RPS8 | ribosomal protein S8 | 0.053157 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0527684 |
| RPL35A | ribosomal protein L35a | 0.0526507 |
| ITGAV | integrin, alpha V | 0.0521546 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0518125 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0515352 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0480431 |
| RPL23 | ribosomal protein L23 | 0.0472875 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.047093 |
| LDHA | lactate dehydrogenase A | 0.0467807 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0459478 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0454887 |
| PCDH9 | protocadherin 9 | 0.0452203 |
| CDC73 | cell division cycle 73 | 0.0450954 |
| RPL7 | ribosomal protein L7 | 0.0446836 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0435583 |
| PRTG | protogenin | 0.0433593 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.043161 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0412428 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0411062 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0409405 |
| MTF2 | metal response element binding transcription factor 2 | 0.0394548 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0390231 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0380693 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0372202 |
| ENAH | enabled homolog (Drosophila) | 0.0364281 |
| SETD5 | SET domain containing 5 | 0.036426 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.036003 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0359404 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0359137 |
| MPG | N-methylpurine-DNA glycosylase | 0.0358388 |
| RASAL2 | RAS protein activator like 2 | 0.0355081 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0353416 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.035253 |
| RPL31 | ribosomal protein L31 | 0.0349657 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0348482 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0347911 |
| RPL5 | ribosomal protein L5 | 0.034605 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0341623 |
| RPS13 | ribosomal protein S13 | 0.034053 |
| RPL37 | ribosomal protein L37 | 0.0339284 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0336348 |
| SRP54 | signal recognition particle 54kDa | 0.0331507 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0328648 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0325844 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0325267 |
| SOX2 | SRY (sex determining region Y)-box 2 | 0.0325249 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0319267 |
| FST | follistatin | 0.0316814 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0310477 |
| RPLP0 | ribosomal protein, large, P0 | 0.0309961 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0307472 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.030554 |
| MED13L | mediator complex subunit 13-like | 0.030487 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0301399 |
| USP3 | ubiquitin specific peptidase 3 | 0.0301318 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0300295 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0297806 |
| DSTN | destrin (actin depolymerizing factor) | 0.029759 |
| RPS21 | ribosomal protein S21 | 0.0296979 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0295723 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0295684 |
| MEMO1 | mediator of cell motility 1 | 0.0295602 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0295296 |
| CLTC | clathrin, heavy chain (Hc) | 0.0293709 |
| CADM2 | cell adhesion molecule 2 | 0.0292292 |
| LDHB | lactate dehydrogenase B | 0.0290984 |
| OLA1 | Obg-like ATPase 1 | 0.0289368 |
| WDR43 | WD repeat domain 43 | 0.0288943 |
| VMP1 | vacuole membrane protein 1 | 0.0287064 |
| PLPP1 | phospholipid phosphatase 1 | 0.0286186 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.0283356 |
| RDX | radixin | 0.0282899 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0555476 |
| HMGB1 | high mobility group box 1 | -0.0432176 |
| COL3A1 | collagen, type III, alpha 1 | -0.0430976 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0340791 |
| PTMA | prothymosin, alpha | -0.0301131 |
| RAB31 | RAB31, member RAS oncogene family | -0.0281298 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0243434 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0233842 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0217917 |
| DEPDC1 | DEP domain containing 1 | -0.0207567 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0204808 |
| HIP1 | huntingtin interacting protein 1 | -0.0200286 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0197414 |
| DIAPH3 | diaphanous-related formin 3 | -0.0197029 |
| EGFR | epidermal growth factor receptor | -0.0195243 |
| CENPE | centromere protein E, 312kDa | -0.0189797 |
| MKI67 | marker of proliferation Ki-67 | -0.0183578 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0183196 |
| CAVIN1 | caveolae associated protein 1 | -0.0180997 |
| SRP72 | signal recognition particle 72kDa | -0.0173126 |
| AHNAK | AHNAK nucleoprotein | -0.0172794 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0170197 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0170127 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.016863 |
| EXOC6B | exocyst complex component 6B | -0.0167404 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0166286 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0165701 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0165529 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0161662 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0161565 |
| FBXO9 | F-box protein 9 | -0.0159613 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0159121 |
| DEK | DEK proto-oncogene | -0.0158291 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.015792 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0157409 |
| R3HDM1 | R3H domain containing 1 | -0.015564 |
| GPATCH8 | G patch domain containing 8 | -0.0154941 |
| ZNF609 | zinc finger protein 609 | -0.0154742 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0154405 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.0153971 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0153531 |
| STK4 | serine/threonine kinase 4 | -0.0153493 |
| ZNF106 | zinc finger protein 106 | -0.0153378 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0152467 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0152038 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -0.0151769 |
| CCDC18 | coiled-coil domain containing 18 | -0.0151754 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0151751 |
| RNF149 | ring finger protein 149 | -0.0150911 |
| CENPF | centromere protein F, 350/400kDa | -0.015019 |
| GOLGA3 | golgin A3 | -0.0148602 |
| AAK1 | AP2 associated kinase 1 | -0.014758 |
| BRCA1 | breast cancer 1, early onset | -0.0147473 |
| UBTF | upstream binding transcription factor, RNA polymerase I | -0.0147361 |
| SMAD3 | SMAD family member 3 | -0.0146358 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0145891 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0145735 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0145371 |
| FBXO17 | F-box protein 17 | -0.0143771 |
| NF1 | neurofibromin 1 | -0.0141712 |
| KIAA1328 | KIAA1328 | -0.0140503 |
| KHSRP | KH-type splicing regulatory protein | -0.0140476 |
| H1-0 | H1.0 linker histone | -0.0140469 |
| TRIM56 | tripartite motif containing 56 | -0.0140216 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0139923 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0139413 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0139258 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0138826 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0138496 |
| FOXP1 | forkhead box P1 | -0.0137232 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0136723 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.0136447 |
| NFIA | nuclear factor I/A | -0.0136368 |
| TCF12 | transcription factor 12 | -0.0135509 |
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | -0.0133707 |
| SLC30A8 | solute carrier family 30 (zinc transporter), member 8 | -0.0133197 |
| AGO3 | argonaute RISC catalytic component 3 | -0.013273 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.0132578 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0132239 |
| BRIX1 | BRX1, biogenesis of ribosomes | -0.0131962 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.013081 |
| CS | citrate synthase | -0.013019 |
| CLIC4 | chloride intracellular channel 4 | -0.0130155 |
| STX8 | syntaxin 8 | -0.0129059 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0128254 |
| RNF169 | ring finger protein 169 | -0.0128173 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.0127661 |
| RPL38 | ribosomal protein L38 | -0.0127191 |
| RPL14 | ribosomal protein L14 | -0.0126876 |
| TMEM263 | transmembrane protein 263 | -0.0126849 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0126314 |
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | -0.0126308 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0126204 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0125923 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0125747 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0125736 |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | -0.0125588 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0125499 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | -0.0125373 |
| NOL7 | nucleolar protein 7, 27kDa | -0.0125342 |
