| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.193152 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.160542 |
| FRMD4A | FERM domain containing 4A | 0.157281 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.144453 |
| FN1 | fibronectin 1 | 0.138628 |
| PDE10A | phosphodiesterase 10A | 0.128949 |
| PGK1 | phosphoglycerate kinase 1 | 0.114009 |
| FNDC3B | fibronectin type III domain containing 3B | 0.107131 |
| CD44 | CD44 molecule (Indian blood group) | 0.100566 |
| DST | dystonin | 0.0915255 |
| NAV2 | neuron navigator 2 | 0.0913202 |
| CADM1 | cell adhesion molecule 1 | 0.0870498 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0845782 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0829913 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0822766 |
| MYOF | myoferlin | 0.0819956 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0812791 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0810292 |
| BICC1 | BicC family RNA binding protein 1 | 0.079123 |
| LDHA | lactate dehydrogenase A | 0.0772005 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0749857 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0740689 |
| VCL | vinculin | 0.0737137 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0722225 |
| JMJD1C | jumonji domain containing 1C | 0.0704053 |
| ZNF292 | zinc finger protein 292 | 0.0677009 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0656342 |
| CENPF | centromere protein F, 350/400kDa | 0.0637529 |
| MKI67 | marker of proliferation Ki-67 | 0.0634902 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0634832 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0603474 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0594223 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0592042 |
| VCAN | versican | 0.0580655 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0580172 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0571681 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0554339 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0537892 |
| ANLN | anillin, actin binding protein | 0.0532178 |
| RTN4 | reticulon 4 | 0.052191 |
| ANXA2 | annexin A2 | 0.0508839 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0505105 |
| FLNB | filamin B, beta | 0.0499287 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0491551 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0489018 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.047989 |
| KIF4A | kinesin family member 4A | 0.0478247 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0466506 |
| SPAG9 | sperm associated antigen 9 | 0.0459539 |
| THBS1 | thrombospondin 1 | 0.0456334 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0456255 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0455884 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0455199 |
| TPX2 | TPX2, microtubule-associated | 0.0454352 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0450929 |
| TPM4 | tropomyosin 4 | 0.0449431 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0439426 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0425469 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0411777 |
| IL6ST | interleukin 6 signal transducer | 0.040956 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0409083 |
| SBF2 | SET binding factor 2 | 0.0408322 |
| CDCP1 | CUB domain containing protein 1 | 0.0395669 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0394417 |
| ARRDC3 | arrestin domain containing 3 | 0.0393367 |
| COL1A2 | collagen, type I, alpha 2 | 0.0392586 |
| DIAPH3 | diaphanous-related formin 3 | 0.038861 |
| SMC4 | structural maintenance of chromosomes 4 | 0.038401 |
| PRELID2 | PRELI domain containing 2 | 0.0377804 |
| MX1 | MX dynamin-like GTPase 1 | 0.0363578 |
| TMEM123 | transmembrane protein 123 | 0.0363198 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0362458 |
| TUBB | tubulin, beta class I | 0.0361157 |
| CUL4B | cullin 4B | 0.0359497 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0355306 |
| ACTN1 | actinin, alpha 1 | 0.0346303 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0345332 |
| CKAP5 | cytoskeleton associated protein 5 | 0.032986 |
| FRMD5 | FERM domain containing 5 | 0.0326518 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0325808 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0325591 |
| OGA | O-GlcNAcase | 0.0325577 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0325506 |
| AFDN | afadin, adherens junction formation factor | 0.0324024 |
| RBM39 | RNA binding motif protein 39 | 0.0319919 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0317414 |
| ATXN1 | ataxin 1 | 0.0316711 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0312864 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0312364 |
| SMYD3 | SET and MYND domain containing 3 | 0.0308899 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0306723 |
| LRRC7 | leucine rich repeat containing 7 | 0.0306189 |
| SMAD3 | SMAD family member 3 | 0.0305329 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.030459 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0304336 |
| PKM | pyruvate kinase, muscle | 0.0296623 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0295517 |
| AHNAK | AHNAK nucleoprotein | 0.0295059 |
| ANXA5 | annexin A5 | 0.0292881 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0292761 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.100244 |
| VEGFA | vascular endothelial growth factor A | -0.0617662 |
| INTS6 | integrator complex subunit 6 | -0.0537039 |
| HMGA2 | high mobility group AT-hook 2 | -0.0518612 |
| FTL | ferritin, light polypeptide | -0.0505919 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0467555 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0456961 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0421611 |
| VIM | vimentin | -0.0404516 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0378012 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0375206 |
| CDH13 | cadherin 13 | -0.0374563 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0362998 |
| TMSB10 | thymosin beta 10 | -0.0352322 |
| NDRG1 | N-myc downstream regulated 1 | -0.0320744 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0311076 |
| RPS12 | ribosomal protein S12 | -0.0307813 |
| RPL35A | ribosomal protein L35a | -0.0300436 |
| COL5A1 | collagen, type V, alpha 1 | -0.0293941 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0293545 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0283183 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0281763 |
| RPL23 | ribosomal protein L23 | -0.027131 |
| ASPH | aspartate beta-hydroxylase | -0.026974 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.026835 |
| RPLP2 | ribosomal protein, large, P2 | -0.0264084 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0263412 |
| RPS19 | ribosomal protein S19 | -0.0256708 |
| TMEM132D | transmembrane protein 132D | -0.0252892 |
| RPL9 | ribosomal protein L9 | -0.0250092 |
| ACTG1 | actin gamma 1 | -0.0241927 |
| RPS8 | ribosomal protein S8 | -0.0235864 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0225971 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0219886 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0215402 |
| CTBP2 | C-terminal binding protein 2 | -0.0213426 |
| RND3 | Rho family GTPase 3 | -0.0212139 |
| RPS13 | ribosomal protein S13 | -0.0199112 |
| RPLP1 | ribosomal protein, large, P1 | -0.0198865 |
| RPL36A | ribosomal protein L36a | -0.0197361 |
| TBCA | tubulin folding cofactor A | -0.0197325 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0195792 |
| RPS23 | ribosomal protein S23 | -0.0193251 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0193115 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0188864 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0184719 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0184209 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0183745 |
| RPL26 | ribosomal protein L26 | -0.0179003 |
| RPL7A | ribosomal protein L7a | -0.0175382 |
| RPL28 | ribosomal protein L28 | -0.0174632 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0173554 |
| HMGA1 | high mobility group AT-hook 1 | -0.0171679 |
| RPL35 | ribosomal protein L35 | -0.0170294 |
| SHISA5 | shisa family member 5 | -0.016916 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | -0.0167669 |
| CALR | calreticulin | -0.0167593 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0164832 |
| RPL37A | ribosomal protein L37a | -0.0164451 |
| RPS27 | ribosomal protein S27 | -0.016296 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0157691 |
| AEBP2 | AE binding protein 2 | -0.0157654 |
| KLHL29 | kelch-like family member 29 | -0.0154598 |
| EFNA5 | ephrin-A5 | -0.0151925 |
| RPS3 | ribosomal protein S3 | -0.0151585 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0150603 |
| TUT7 | terminal uridylyl transferase 7 | -0.015009 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0149595 |
| RPL31 | ribosomal protein L31 | -0.0149546 |
| ATP11C | ATPase, class VI, type 11C | -0.014757 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0147458 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0147092 |
| DENND1A | DENN/MADD domain containing 1A | -0.0146779 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0145878 |
| RPS10 | ribosomal protein S10 | -0.0145371 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0145219 |
| RPS14 | ribosomal protein S14 | -0.0144004 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0143971 |
| CUX1 | cut-like homeobox 1 | -0.014332 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0142329 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0141998 |
| RPL5 | ribosomal protein L5 | -0.0141532 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.0139012 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0137688 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0137335 |
| RPL12 | ribosomal protein L12 | -0.0136998 |
| RPS6 | ribosomal protein S6 | -0.0136203 |
| RPL36 | ribosomal protein L36 | -0.0135498 |
| CCND1 | cyclin D1 | -0.0135405 |
| S100A9 | S100 calcium binding protein A9 | -0.0134825 |
| USP53 | ubiquitin specific peptidase 53 | -0.0134004 |
| VAC14 | Vac14 homolog (S. cerevisiae) | -0.0133049 |
| WDR27 | WD repeat domain 27 | -0.0132564 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0132364 |
| RPL11 | ribosomal protein L11 | -0.0132083 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0131908 |
| IRS2 | insulin receptor substrate 2 | -0.0131778 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0131165 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0130961 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0130462 |
