| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.178458 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.136409 |
| FTL | ferritin, light polypeptide | 0.0821574 |
| B2M | beta-2-microglobulin | 0.0813155 |
| ADM | adrenomedullin | 0.0672994 |
| TMSB10 | thymosin beta 10 | 0.0661833 |
| NDRG1 | N-myc downstream regulated 1 | 0.0566539 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0538985 |
| RPL35A | ribosomal protein L35a | 0.0517859 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.050167 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0489951 |
| RPS23 | ribosomal protein S23 | 0.0487278 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0440849 |
| RPS21 | ribosomal protein S21 | 0.043192 |
| HMGA2 | high mobility group AT-hook 2 | 0.0427542 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0426227 |
| CAST | calpastatin | 0.0421466 |
| SEC24A | SEC24 family member A | 0.0405242 |
| RPLP1 | ribosomal protein, large, P1 | 0.0403073 |
| FMNL2 | formin-like 2 | 0.0392259 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.038961 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0377601 |
| RBM39 | RNA binding motif protein 39 | 0.0374747 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0371589 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0368222 |
| MYO1E | myosin IE | 0.0367755 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.036457 |
| NEBL | nebulette | 0.0351015 |
| WASF2 | WAS protein family, member 2 | 0.0350124 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0348477 |
| LMNA | lamin A/C | 0.0347099 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0343255 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0342344 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0335094 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0333868 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0328136 |
| MRPL1 | mitochondrial ribosomal protein L1 | 0.0325544 |
| CORO1C | coronin, actin binding protein, 1C | 0.0325134 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0324598 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0324549 |
| RPL34 | ribosomal protein L34 | 0.0321502 |
| RPS14 | ribosomal protein S14 | 0.0321331 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0319189 |
| MT1X | metallothionein 1X | 0.0314087 |
| PRICKLE2 | prickle homolog 2 (Drosophila) | 0.0313814 |
| CD44 | CD44 molecule (Indian blood group) | 0.0313785 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0312658 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.0309877 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0306598 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0303885 |
| GPC6 | glypican 6 | 0.0302482 |
| LSAMP | limbic system-associated membrane protein | 0.030175 |
| FCHO2 | FCH domain only 2 | 0.0299792 |
| ANLN | anillin, actin binding protein | 0.0293519 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0293461 |
| GNAS | GNAS complex locus | 0.0291408 |
| PEG10 | paternally expressed 10 | 0.0291325 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.029103 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0291019 |
| BMERB1 | bMERB domain containing 1 | 0.0290524 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0290307 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0288529 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0285614 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0285461 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0282672 |
| RPL19 | ribosomal protein L19 | 0.0281947 |
| PRKAR2A | protein kinase, cAMP-dependent, regulatory, type II, alpha | 0.027841 |
| SVIL | supervillin | 0.0278087 |
| STC1 | stanniocalcin 1 | 0.0277196 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0276179 |
| RPL11 | ribosomal protein L11 | 0.0275727 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0275521 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0273347 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.0270968 |
| PDE10A | phosphodiesterase 10A | 0.0270446 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0268326 |
| RPS12 | ribosomal protein S12 | 0.0267186 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0267099 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.026393 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0262256 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0259236 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0258048 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0257969 |
| RPL9 | ribosomal protein L9 | 0.0257599 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0256865 |
| HMGA1 | high mobility group AT-hook 1 | 0.0255537 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0250186 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0250115 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0248836 |
| RPS4X | ribosomal protein S4, X-linked | 0.0247567 |
| RPN2 | ribophorin II | 0.0247454 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0247289 |
| NPTN | neuroplastin | 0.0245947 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0245378 |
| RPL36 | ribosomal protein L36 | 0.0244511 |
| GOLGA4 | golgin A4 | 0.0243062 |
| MTPN | myotrophin | 0.0242393 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0241404 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0240159 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0239263 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | -0.467522 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.198959 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.15845 |
| COL1A1 | collagen, type I, alpha 1 | -0.143164 |
| LOX | lysyl oxidase | -0.142888 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.126983 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.119046 |
| COL1A2 | collagen, type I, alpha 2 | -0.117308 |
| FN1 | fibronectin 1 | -0.109524 |
| AHNAK | AHNAK nucleoprotein | -0.0879069 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0853793 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0818231 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0814276 |
| GLIS3 | GLIS family zinc finger 3 | -0.0762307 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0752123 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0731187 |
| CANX | calnexin | -0.0649333 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0642347 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0631335 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0628688 |
| NRXN3 | neurexin 3 | -0.0618818 |
| COL3A1 | collagen, type III, alpha 1 | -0.0604003 |
| LOXL2 | lysyl oxidase-like 2 | -0.059743 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0571489 |
| TPM4 | tropomyosin 4 | -0.0570551 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0547248 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.051007 |
| ENO1 | enolase 1, (alpha) | -0.0465469 |
| COL5A2 | collagen, type V, alpha 2 | -0.0458763 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0457328 |
| CALU | calumenin | -0.0451443 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0431452 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0428278 |
| POTEF | POTE ankyrin domain family, member F | -0.0427663 |
| PLCB4 | phospholipase C, beta 4 | -0.0410714 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0405703 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.039964 |
| SMYD3 | SET and MYND domain containing 3 | -0.0399567 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0398996 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0397003 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0390909 |
| HDLBP | high density lipoprotein binding protein | -0.0390664 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0390505 |
| HIP1 | huntingtin interacting protein 1 | -0.0389758 |
| SCARB2 | scavenger receptor class B, member 2 | -0.038517 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0366872 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0366448 |
| HLA-C | major histocompatibility complex, class I, C | -0.0365261 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0359788 |
| COL5A1 | collagen, type V, alpha 1 | -0.0359574 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0358522 |
| CENPF | centromere protein F, 350/400kDa | -0.0357983 |
| TMEM165 | transmembrane protein 165 | -0.0350148 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0345889 |
| UBC | ubiquitin C | -0.0340281 |
| SDC4 | syndecan 4 | -0.0340077 |
| SMAD3 | SMAD family member 3 | -0.0339402 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0331473 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0328197 |
| ASPH | aspartate beta-hydroxylase | -0.031966 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0317437 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0316251 |
| RAB10 | RAB10, member RAS oncogene family | -0.0313739 |
| C1D | C1D nuclear receptor corepressor | -0.0313091 |
| RAI14 | retinoic acid induced 14 | -0.0310256 |
| JAZF1 | JAZF zinc finger 1 | -0.0309554 |
| ATP13A3 | ATPase type 13A3 | -0.030918 |
| CADM1 | cell adhesion molecule 1 | -0.0296997 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0295474 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0293157 |
| BSG | basigin (Ok blood group) | -0.0289725 |
| PXDN | peroxidasin | -0.0288736 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0286926 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0285834 |
| PDLIM5 | PDZ and LIM domain 5 | -0.028528 |
| CDH13 | cadherin 13 | -0.0282481 |
| DST | dystonin | -0.0279962 |
| NRP1 | neuropilin 1 | -0.0278906 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0277454 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0276073 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0275152 |
| FAM20C | family with sequence similarity 20, member C | -0.0273787 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0272498 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0269189 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.026766 |
| CDK6 | cyclin-dependent kinase 6 | -0.0265873 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0263216 |
| LAMA4 | laminin, alpha 4 | -0.0262675 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0262106 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0260494 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0259664 |
| CTSB | cathepsin B | -0.0258784 |
| TPM1 | tropomyosin 1 (alpha) | -0.0258279 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0257186 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0257175 |
| SEC24D | SEC24 family member D | -0.025651 |
| IL6 | interleukin 6 | -0.0254361 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0252396 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0250896 |
| ZNF148 | zinc finger protein 148 | -0.0250633 |
