| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0984675 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0780954 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0716372 |
| SET | SET nuclear proto-oncogene | 0.06109 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0585095 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0563866 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0539482 |
| GOLGA4 | golgin A4 | 0.0521461 |
| RORA | RAR-related orphan receptor A | 0.049402 |
| FMNL2 | formin-like 2 | 0.0486989 |
| NUP58 | nucleoporin 58 | 0.0471175 |
| PCBP2 | poly(rC) binding protein 2 | 0.046225 |
| PRKD1 | protein kinase D1 | 0.045612 |
| YAP1 | Yes-associated protein 1 | 0.0447085 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0443997 |
| GNAS | GNAS complex locus | 0.042152 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0416919 |
| SMYD3 | SET and MYND domain containing 3 | 0.0409479 |
| RPS20 | ribosomal protein S20 | 0.0407267 |
| RBM39 | RNA binding motif protein 39 | 0.0404955 |
| GPATCH2L | G patch domain containing 2-like | 0.0403959 |
| BRD2 | bromodomain containing 2 | 0.0402779 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0400813 |
| TOP1 | topoisomerase (DNA) I | 0.0398318 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.039082 |
| NGLY1 | N-glycanase 1 | 0.0390632 |
| NPTN | neuroplastin | 0.0384456 |
| TNPO1 | transportin 1 | 0.0380332 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0365793 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0364664 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0357065 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0356808 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0356296 |
| CDCP1 | CUB domain containing protein 1 | 0.0354624 |
| HJURP | Holliday junction recognition protein | 0.0351832 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0348313 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0348009 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0346416 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0346287 |
| NKTR | natural killer cell triggering receptor | 0.0340413 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0332241 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0328389 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0327166 |
| RPLP1 | ribosomal protein, large, P1 | 0.0323063 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0321835 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0320565 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.0320402 |
| CCNH | cyclin H | 0.0316709 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.030988 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0308995 |
| HM13 | histocompatibility (minor) 13 | 0.0300367 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0299489 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0297633 |
| PRELID2 | PRELI domain containing 2 | 0.0296712 |
| TLK1 | tousled-like kinase 1 | 0.0294893 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0293835 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0293161 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0293008 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0292078 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0291277 |
| PRKCA | protein kinase C, alpha | 0.0287658 |
| RPL4 | ribosomal protein L4 | 0.0284534 |
| PKM | pyruvate kinase, muscle | 0.0284282 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0284116 |
| ATXN1 | ataxin 1 | 0.0283294 |
| RPL23 | ribosomal protein L23 | 0.0281932 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0280068 |
| ENO1 | enolase 1, (alpha) | 0.0279434 |
| ATP13A3 | ATPase type 13A3 | 0.0277377 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0276132 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0275971 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0272094 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0272069 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0271341 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0270685 |
| GOLGB1 | golgin B1 | 0.0269227 |
| YLPM1 | YLP motif containing 1 | 0.0268947 |
| SMAP1 | small ArfGAP 1 | 0.026765 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0266078 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0264744 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0263923 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0263442 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0262128 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0261563 |
| SRP54 | signal recognition particle 54kDa | 0.0261423 |
| RPS3 | ribosomal protein S3 | 0.0260721 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0260538 |
| RBM5 | RNA binding motif protein 5 | 0.0258468 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0258058 |
| NBAS | neuroblastoma amplified sequence | 0.0254851 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0254591 |
| COLEC11 | collectin sub-family member 11 | 0.025446 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0254181 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.025283 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0251724 |
| LDHB | lactate dehydrogenase B | 0.0250973 |
| NOP58 | NOP58 ribonucleoprotein | 0.0249929 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0248693 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0247542 |
| RPN2 | ribophorin II | 0.0247159 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0947066 |
| PTMA | prothymosin, alpha | -0.0781657 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0709806 |
| CD44 | CD44 molecule (Indian blood group) | -0.0692762 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.059908 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0524091 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0518216 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0472146 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.046478 |
| IGF2 | insulin-like growth factor 2 | -0.0446586 |
| NF1 | neurofibromin 1 | -0.0436853 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0412159 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0407416 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0399809 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0398028 |
| RIGI | RNA sensor RIG-I | -0.0388191 |
| GPATCH8 | G patch domain containing 8 | -0.0383297 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0377104 |
| FLNB | filamin B, beta | -0.0374477 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0362862 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0356796 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0347356 |
| HMGA2 | high mobility group AT-hook 2 | -0.0338277 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0335084 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0322051 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.031794 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0316828 |
| MYO9B | myosin IXB | -0.0307549 |
| SDC4 | syndecan 4 | -0.0307425 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.030511 |
| CUX1 | cut-like homeobox 1 | -0.0301401 |
| LDHA | lactate dehydrogenase A | -0.0300577 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.030048 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0289771 |
| RNF213 | ring finger protein 213 | -0.0287026 |
| UTRN | utrophin | -0.0280068 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0279593 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0278986 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0278021 |
| GPC6 | glypican 6 | -0.0277012 |
| CAPRIN2 | caprin family member 2 | -0.0275252 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0273487 |
| CSPP1 | centrosome and spindle pole associated protein 1 | -0.0271674 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0262822 |
| LMO7 | LIM domain 7 | -0.0257541 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.0254945 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.025437 |
| FAM193A | family with sequence similarity 193, member A | -0.0254368 |
| NAV3 | neuron navigator 3 | -0.0253394 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0251512 |
| FRMD6 | FERM domain containing 6 | -0.024817 |
| TXNRD1 | thioredoxin reductase 1 | -0.0247445 |
| ARPC3 | actin related protein 2/3 complex, subunit 3, 21kDa | -0.0245897 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0245428 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | -0.0244242 |
| RIN2 | Ras and Rab interactor 2 | -0.0243756 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0242743 |
| INTS6 | integrator complex subunit 6 | -0.0242256 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0240547 |
| DENND5B | DENN/MADD domain containing 5B | -0.0239708 |
| PDS5A | PDS5 cohesin associated factor A | -0.0239217 |
| RAD50 | RAD50 homolog (S. cerevisiae) | -0.0238924 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.023814 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | -0.023813 |
| NBR1 | neighbor of BRCA1 gene 1 | -0.0235604 |
| HDAC9 | histone deacetylase 9 | -0.0234656 |
| GOLGA3 | golgin A3 | -0.0233262 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0232907 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0228176 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0227252 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0227016 |
| CDK12 | cyclin-dependent kinase 12 | -0.0226124 |
| AXL | AXL receptor tyrosine kinase | -0.0222766 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0222759 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0222453 |
| DZIP1 | DAZ interacting zinc finger protein 1 | -0.0222247 |
| KLC1 | kinesin light chain 1 | -0.0222198 |
| CEP290 | centrosomal protein 290kDa | -0.0221649 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | -0.0221024 |
| PHIP | pleckstrin homology domain interacting protein | -0.0219819 |
| HDAC4 | histone deacetylase 4 | -0.0219625 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0218661 |
| RAI14 | retinoic acid induced 14 | -0.0217026 |
| ATM | ATM serine/threonine kinase | -0.0216607 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0214332 |
| NXN | nucleoredoxin | -0.021382 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0212343 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0211601 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0211133 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.021095 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | -0.0208165 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0207781 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0206802 |
| DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21 | -0.0206118 |
| CDK8 | cyclin-dependent kinase 8 | -0.0205007 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0204344 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0203661 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0203159 |
| FAM222B | family with sequence similarity 222, member B | -0.0202733 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0202182 |
