| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Simotinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Simotinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.283065 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.220381 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.208098 |
| FNDC3B | fibronectin type III domain containing 3B | 0.130321 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.129591 |
| ITGA1 | integrin, alpha 1 | 0.113216 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.107994 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.101756 |
| ASPH | aspartate beta-hydroxylase | 0.0918098 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0853442 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0804351 |
| CENPF | centromere protein F, 350/400kDa | 0.0792326 |
| AHR | aryl hydrocarbon receptor | 0.0774891 |
| NRG1 | neuregulin 1 | 0.0694005 |
| FN1 | fibronectin 1 | 0.0675883 |
| TMEM156 | transmembrane protein 156 | 0.0645511 |
| CANX | calnexin | 0.0633542 |
| PRELID2 | PRELI domain containing 2 | 0.0617868 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0611915 |
| DST | dystonin | 0.0605646 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0597265 |
| GLIS3 | GLIS family zinc finger 3 | 0.0539982 |
| PTK2 | protein tyrosine kinase 2 | 0.0517287 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0505511 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0505101 |
| HMGA2 | high mobility group AT-hook 2 | 0.0502937 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0499529 |
| CD109 | CD109 molecule | 0.049588 |
| SMYD3 | SET and MYND domain containing 3 | 0.0471829 |
| OSMR | oncostatin M receptor | 0.0471071 |
| FAM13A | family with sequence similarity 13, member A | 0.0470601 |
| EFNA5 | ephrin-A5 | 0.0469243 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0444737 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0438122 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0437124 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.043453 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.04234 |
| PLIN2 | perilipin 2 | 0.041837 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0416287 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.041322 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0408747 |
| MKI67 | marker of proliferation Ki-67 | 0.040776 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0399889 |
| ATXN1 | ataxin 1 | 0.0396055 |
| TPR | translocated promoter region, nuclear basket protein | 0.039486 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0388023 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0383865 |
| GPC6 | glypican 6 | 0.0356132 |
| PGK1 | phosphoglycerate kinase 1 | 0.0354877 |
| PKM | pyruvate kinase, muscle | 0.0351522 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0350968 |
| ZNF292 | zinc finger protein 292 | 0.033982 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0336702 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0331983 |
| RUNX1 | runt-related transcription factor 1 | 0.0325508 |
| RBM39 | RNA binding motif protein 39 | 0.0323095 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.031844 |
| NDRG1 | N-myc downstream regulated 1 | 0.0318429 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.031575 |
| RUNX2 | runt-related transcription factor 2 | 0.0313867 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0312194 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0311094 |
| LOXL2 | lysyl oxidase-like 2 | 0.0309593 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0306375 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0306213 |
| RAD51B | RAD51 paralog B | 0.0305522 |
| TPI1 | triosephosphate isomerase 1 | 0.0297094 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0290334 |
| VEGFC | vascular endothelial growth factor C | 0.0290198 |
| NAV2 | neuron navigator 2 | 0.0290126 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0288833 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.028791 |
| LDHA | lactate dehydrogenase A | 0.0287156 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0285304 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0280566 |
| ITGB5 | integrin, beta 5 | 0.0276463 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0276368 |
| ZNF638 | zinc finger protein 638 | 0.0275281 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0275138 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0274111 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0274002 |
| SGO2 | shugoshin 2 | 0.0273622 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0273404 |
| AFDN | afadin, adherens junction formation factor | 0.027316 |
| TXNRD1 | thioredoxin reductase 1 | 0.0271428 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0270559 |
| CDCP1 | CUB domain containing protein 1 | 0.0270449 |
| HELZ | helicase with zinc finger | 0.0270056 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0268848 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0265836 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0265639 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0265096 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0262485 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0261982 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.026081 |
| EREG | epiregulin | 0.0260335 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0258154 |
| CLTC | clathrin, heavy chain (Hc) | 0.0254555 |
| ENO1 | enolase 1, (alpha) | 0.0252898 |
| PELO | pelota homolog (Drosophila) | 0.0251057 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0483891 |
| PTMA | prothymosin, alpha | -0.0414373 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0333795 |
| NTN4 | netrin 4 | -0.0306247 |
| FTL | ferritin, light polypeptide | -0.0298641 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0280922 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0275268 |
| PALLD | palladin, cytoskeletal associated protein | -0.0247967 |
| VMP1 | vacuole membrane protein 1 | -0.0231304 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0212636 |
| CALR | calreticulin | -0.0204074 |
| NOP58 | NOP58 ribonucleoprotein | -0.0199061 |
| RPL35A | ribosomal protein L35a | -0.0195307 |
| EGR1 | early growth response 1 | -0.0190041 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0189745 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0186989 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0186215 |
| ACTG1 | actin gamma 1 | -0.0183337 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0177402 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0177047 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0174906 |
| VEGFA | vascular endothelial growth factor A | -0.0173185 |
| WDR43 | WD repeat domain 43 | -0.0170582 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0168434 |
| RPLP2 | ribosomal protein, large, P2 | -0.0167612 |
| RPS23 | ribosomal protein S23 | -0.0166919 |
| RPS29 | ribosomal protein S29 | -0.0166094 |
| RPS19 | ribosomal protein S19 | -0.0164553 |
| RAB10 | RAB10, member RAS oncogene family | -0.0163263 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0162854 |
| RPL12 | ribosomal protein L12 | -0.0157721 |
| POTEF | POTE ankyrin domain family, member F | -0.0156414 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0155409 |
| BRD2 | bromodomain containing 2 | -0.0155282 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0152832 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0148431 |
| RPL8 | ribosomal protein L8 | -0.0145404 |
| TGFB1 | transforming growth factor, beta 1 | -0.0144463 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0144038 |
| RPL21 | ribosomal protein L21 | -0.0138782 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0136886 |
| KSR1 | kinase suppressor of ras 1 | -0.0134623 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0131322 |
| BSG | basigin (Ok blood group) | -0.0129262 |
| NXN | nucleoredoxin | -0.0129183 |
| SMIM44 | small integral membrane protein 44 | -0.0128869 |
| TP53BP1 | tumor protein p53 binding protein 1 | -0.0126659 |
| INTS6 | integrator complex subunit 6 | -0.0124986 |
| RPL36A | ribosomal protein L36a | -0.0123508 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.012219 |
| CCDC138 | coiled-coil domain containing 138 | -0.0120417 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0117175 |
| RPS14 | ribosomal protein S14 | -0.0117051 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0115092 |
| RPS25 | ribosomal protein S25 | -0.0114098 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0113921 |
| CDK13 | cyclin-dependent kinase 13 | -0.0112097 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0111957 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.011177 |
| RPL19 | ribosomal protein L19 | -0.0110857 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0110236 |
| DENND4A | DENN/MADD domain containing 4A | -0.0109154 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0108459 |
| FERMT2 | fermitin family member 2 | -0.0108107 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.010781 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0107491 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | -0.0106786 |
| RPL37 | ribosomal protein L37 | -0.0106524 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0105239 |
| UBAP1 | ubiquitin associated protein 1 | -0.0105108 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0103607 |
| SFTPA2 | surfactant protein A2 | -0.010275 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0102718 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0102684 |
| DSTN | destrin (actin depolymerizing factor) | -0.0102656 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0101849 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0101646 |
| USP3 | ubiquitin specific peptidase 3 | -0.0101154 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0101059 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0100605 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0100181 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.00999743 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00994898 |
| TJP1 | tight junction protein 1 | -0.00992193 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00977793 |
| MEF2D | myocyte enhancer factor 2D | -0.00972441 |
| CRY1 | cryptochrome circadian clock 1 | -0.00968452 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0096715 |
| SIK2 | salt-inducible kinase 2 | -0.00964445 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.00957095 |
| DHFR | dihydrofolate reductase | -0.00953803 |
| VCL | vinculin | -0.00947602 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.00943143 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.00938454 |
| PRPF39 | pre-mRNA processing factor 39 | -0.00933974 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0093344 |
| WASF2 | WAS protein family, member 2 | -0.00930771 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0092785 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00921997 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | -0.0091673 |
