Simvastatin Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. (Chemical Entities of Biological Interest Ontology, CHEBI_9150)
External Link http://ctdbase.org/detail.go?type=chem&acc=D019821
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Genes

278 genes/proteins interacting with the chemical Simvastatin from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANXA1 annexin A1
ANXA3 annexin A3
APMAP adipocyte plasma membrane associated protein
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOE apolipoprotein E
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
ATF2 activating transcription factor 2
ATF6 activating transcription factor 6
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALB2 calbindin 2
CALD1 caldesmon 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD83 CD83 molecule
CD86 CD86 molecule
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CETP cholesteryl ester transfer protein, plasma
CFLAR CASP8 and FADD-like apoptosis regulator
CHAT choline O-acetyltransferase
CHUK conserved helix-loop-helix ubiquitous kinase
CIITA class II, major histocompatibility complex, transactivator
CKM creatine kinase, muscle
CLCN3 chloride channel, voltage-sensitive 3
CORO1A coronin, actin binding protein, 1A
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSS cathepsin S
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DGAT1 diacylglycerol O-acyltransferase 1
DHCR24 24-dehydrocholesterol reductase
DIABLO diablo, IAP-binding mitochondrial protein
DNM1L dynamin 1-like
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPO erythropoietin
EPOR erythropoietin receptor
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLOT1 flotillin 1
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GATA6 GATA binding protein 6
GDI2 GDP dissociation inhibitor 2
GJA1 gap junction protein, alpha 1, 43kDa
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HTRA2 HtrA serine peptidase 2
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL17A interleukin 17A
IL17F interleukin 17F
IL1B interleukin 1, beta
IL21 interleukin 21
IL22 interleukin 22
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IRF4 interferon regulatory factor 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB4 integrin, beta 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDR kinase insert domain receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LEP leptin
LHB luteinizing hormone beta polypeptide
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MDH1 malate dehydrogenase 1, NAD (soluble)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRAS muscle RAS oncogene homolog
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYH10 myosin, heavy chain 10, non-muscle
NDRG1 N-myc downstream regulated 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPPB natriuretic peptide B
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDGFB platelet-derived growth factor beta polypeptide
PHB2 prohibitin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PTEN phosphatase and tensin homolog
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RHOA ras homolog family member A
RYR2 ryanodine receptor 2 (cardiac)
S100A6 S100 calcium binding protein A6
SCARB1 scavenger receptor class B, member 1
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMAD9 SMAD family member 9
SOCS4 suppressor of cytokine signaling 4
SP7 Sp7 transcription factor
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK11 serine/threonine kinase 11
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEK TEK tyrosine kinase, endothelial
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TPT1 tumor protein, translationally-controlled 1
TYMS thymidylate synthetase
VASP vasodilator-stimulated phosphoprotein
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
VIM vimentin
VWF von Willebrand factor
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase