| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. (Chemical Entities of Biological Interest Ontology, CHEBI_9150) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/54454 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Simvastatin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 3.56 |
| CCDC73 | coiled-coil domain containing 73 | 2.97 |
| ESPN | espin | 2.29 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 2.15 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 2.13 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 2.12 |
| RHOB | ras homolog family member B | 2.02 |
| JUN | jun proto-oncogene | 1.85 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 1.76 |
| KLF2 | Kruppel-like factor 2 | 1.74 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.74 |
| SQLE | squalene epoxidase | 1.57 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 1.52 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 1.52 |
| CCDC28A | coiled-coil domain containing 28A | 1.48 |
| LDLR | low density lipoprotein receptor | 1.47 |
| CLIC3 | chloride intracellular channel 3 | 1.46 |
| HMCN1 | hemicentin 1 | 1.38 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.37 |
| KLK7 | kallikrein-related peptidase 7 | 1.37 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.35 |
| TMEM59 | transmembrane protein 59 | 1.26 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.26 |
| RHOA | ras homolog family member A | 1.24 |
| ITM2B | integral membrane protein 2B | 1.23 |
| MSMO1 | methylsterol monooxygenase 1 | 1.21 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 1.2 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.2 |
| AREG | amphiregulin | 1.13 |
| TCEA2 | transcription elongation factor A (SII), 2 | 1.12 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 1.12 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 1.1 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 1.09 |
| LPIN1 | lipin 1 | 1.05 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 1.05 |
| APP | amyloid beta (A4) precursor protein | 1.03 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.02 |
| TMEM248 | transmembrane protein 248 | 1.01 |
| HAS3 | hyaluronan synthase 3 | 1.0 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 1.0 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.97 |
| VGF | VGF nerve growth factor inducible | 0.96 |
| EREG | epiregulin | 0.95 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.94 |
| ITM2C | integral membrane protein 2C | 0.93 |
| KIAA1217 | KIAA1217 | 0.92 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.92 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.92 |
| APOB | apolipoprotein B | 0.91 |
| HSH2D | hematopoietic SH2 domain containing | 0.91 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | 0.9 |
| KLK6 | kallikrein-related peptidase 6 | 0.89 |
| GINM1 | glycoprotein integral membrane 1 | 0.89 |
| CST3 | cystatin C | 0.89 |
| S100A14 | S100 calcium binding protein A14 | 0.89 |
| L1CAM | L1 cell adhesion molecule | 0.89 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.88 |
| LOXL2 | lysyl oxidase-like 2 | 0.87 |
| MVK | mevalonate kinase | 0.87 |
| RBL2 | retinoblastoma-like 2 | 0.86 |
| STMN3 | stathmin-like 3 | 0.85 |
| RHOC | ras homolog family member C | 0.85 |
| HMOX1 | heme oxygenase 1 | 0.85 |
| CCN3 | cellular communication network factor 3 | 0.84 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.84 |
| AMOT | angiomotin | 0.83 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.83 |
| CDA | cytidine deaminase | 0.83 |
| SYTL2 | synaptotagmin-like 2 | 0.83 |
| ABHD2 | abhydrolase domain containing 2 | 0.83 |
| ABHD3 | abhydrolase domain containing 3 | 0.82 |
| CPE | carboxypeptidase E | 0.82 |
| COL6A1 | collagen, type VI, alpha 1 | 0.81 |
| GATA2 | GATA binding protein 2 | 0.81 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 0.81 |
| RESF1 | retroelement silencing factor 1 | 0.8 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.8 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.79 |
| LAMC2 | laminin, gamma 2 | 0.79 |
| DSC2 | desmocollin 2 | 0.78 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.77 |
| REEP1 | receptor accessory protein 1 | 0.75 |
| PSAP | prosaposin | 0.75 |
| ZNF385A | zinc finger protein 385A | 0.75 |
| EMP3 | epithelial membrane protein 3 | 0.74 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.74 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.74 |
| AMOTL1 | angiomotin like 1 | 0.73 |
| PCDH1 | protocadherin 1 | 0.73 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.72 |
| APOE | apolipoprotein E | 0.72 |
| IFNGR1 | interferon gamma receptor 1 | 0.71 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.71 |
| HGFAC | HGF activator | 0.7 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.7 |
| IL10RB | interleukin 10 receptor, beta | 0.7 |
| RNF145 | ring finger protein 145 | 0.7 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.7 |
| NDRG1 | N-myc downstream regulated 1 | 0.7 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC25A | cell division cycle 25A | -1.38 |
| RAB20 | RAB20, member RAS oncogene family | -1.31 |
| CDC42SE2 | CDC42 small effector 2 | -1.29 |
| SYTL3 | synaptotagmin-like 3 | -1.19 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -1.16 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -1.16 |
| COL1A1 | collagen, type I, alpha 1 | -1.11 |
| WWC2 | WW and C2 domain containing 2 | -1.1 |
| ZNF226 | zinc finger protein 226 | -1.01 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -1.0 |
| DEPDC1B | DEP domain containing 1B | -0.99 |
| RHOF | ras homolog family member F (in filopodia) | -0.98 |
| RAB12 | RAB12, member RAS oncogene family | -0.96 |
| CCN1 | cellular communication network factor 1 | -0.96 |
| FMNL3 | formin-like 3 | -0.95 |
| FBXO34 | F-box protein 34 | -0.91 |
| AJUBA | ajuba LIM protein | -0.86 |
| TTYH2 | tweety family member 2 | -0.82 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -0.82 |
| RAB29 | RAB29, member RAS oncogene family | -0.81 |
| TPM2 | tropomyosin 2 (beta) | -0.81 |
| MUTYH | mutY homolog | -0.78 |
| RGN | regucalcin | -0.74 |
| PCLAF | PCNA clamp associated factor | -0.74 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -0.74 |
| KIF2C | kinesin family member 2C | -0.73 |
| KIF18A | kinesin family member 18A | -0.72 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.72 |
| CDC20 | cell division cycle 20 | -0.72 |
| CCNB1 | cyclin B1 | -0.71 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.71 |
| FBXO46 | F-box protein 46 | -0.71 |
| CDC7 | cell division cycle 7 | -0.7 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.7 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -0.7 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.7 |
| PTTG1 | pituitary tumor-transforming 1 | -0.69 |
| PLK1 | polo-like kinase 1 | -0.69 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.69 |
| VSIR | V-set immunoregulatory receptor | -0.68 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | -0.68 |
| LRR1 | leucine rich repeat protein 1 | -0.68 |
| DEPDC1 | DEP domain containing 1 | -0.67 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.66 |
| RBBP8 | retinoblastoma binding protein 8 | -0.66 |
| COQ4 | coenzyme Q4 | -0.66 |
| PLD6 | phospholipase D family, member 6 | -0.66 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.65 |
| TNS2 | tensin 2 | -0.65 |
| AMOTL2 | angiomotin like 2 | -0.65 |
| ZGRF1 | zinc finger, GRF-type containing 1 | -0.64 |
| CARD10 | caspase recruitment domain family, member 10 | -0.64 |
| AURKA | aurora kinase A | -0.64 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.63 |
| MCPH1 | microcephalin 1 | -0.63 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.63 |
| DONSON | downstream neighbor of SON | -0.63 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.62 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | -0.62 |
| CDCA2 | cell division cycle associated 2 | -0.62 |
| GMNN | geminin, DNA replication inhibitor | -0.61 |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | -0.61 |
| CLSPN | claspin | -0.61 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -0.61 |
| BLM | Bloom syndrome, RecQ helicase-like | -0.61 |
| RAD54L | RAD54-like (S. cerevisiae) | -0.61 |
| CCNB2 | cyclin B2 | -0.61 |
| RRM2 | ribonucleotide reductase M2 | -0.61 |
| RAB8A | RAB8A, member RAS oncogene family | -0.61 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.6 |
| FBXO5 | F-box protein 5 | -0.6 |
| MCM10 | minichromosome maintenance complex component 10 | -0.6 |
| TK1 | thymidine kinase 1, soluble | -0.6 |
| WWC1 | WW and C2 domain containing 1 | -0.6 |
| ARHGAP19 | Rho GTPase activating protein 19 | -0.59 |
| RHOQ | ras homolog family member Q | -0.59 |
| EXO1 | exonuclease 1 | -0.59 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.59 |
| SESN2 | sestrin 2 | -0.59 |
| E2F7 | E2F transcription factor 7 | -0.58 |
| CDC6 | cell division cycle 6 | -0.58 |
| DEPDC7 | DEP domain containing 7 | -0.58 |
| TPX2 | TPX2, microtubule-associated | -0.58 |
| DDX12P | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene | -0.57 |
| CCNA2 | cyclin A2 | -0.56 |
| RAB26 | RAB26, member RAS oncogene family | -0.56 |
| SPICE1 | spindle and centriole associated protein 1 | -0.56 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -0.56 |
| KIF18B | kinesin family member 18B | -0.56 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.56 |
| CDCA5 | cell division cycle associated 5 | -0.56 |
| OBI1 | ORC ubiquitin ligase 1 | -0.56 |
| MIS18BP1 | MIS18 binding protein 1 | -0.55 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -0.55 |
| LAGE3 | L antigen family, member 3 | -0.55 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.55 |
| PRELID3B | PRELI domain containing 3B | -0.55 |
| EPHA2 | EPH receptor A2 | -0.55 |
