Simvastatin Gene Set

Dataset DrugBank Drug Targets
Category physical interactions
Type drug
Description A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. (Chemical Entities of Biological Interest Ontology, CHEBI_9150)
External Link http://www.drugbank.ca/drugs/DB00641
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Genes

15 interacting proteins for the Simvastatin drug from the curated DrugBank Drug Targets dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7