Simvastatin Gene Set

Dataset HMDB Metabolites of Enzymes
Category physical interactions
Type metabolite
Description A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. (Chemical Entities of Biological Interest Ontology, CHEBI_9150)
External Link http://www.hmdb.ca/metabolites/HMDB05007
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Genes

24 interacting proteins for the Simvastatin metabolite from the curated HMDB Metabolites of Enzymes dataset.

Symbol Name
ACVR1 activin A receptor, type I
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CD40 CD40 molecule, TNF receptor superfamily member 5
COL13A1 collagen, type XIII, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL6 interleukin 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LTB lymphotoxin beta (TNF superfamily, member 3)
MAPK3 mitogen-activated protein kinase 3
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
PPARA peroxisome proliferator-activated receptor alpha
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOA ras homolog family member A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TNF tumor necrosis factor
VEGFA vascular endothelial growth factor A