Sinomenine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sinomenine perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sinomenine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.142805
AKAP12 A kinase (PRKA) anchor protein 12 0.101998
EXT1 exostosin glycosyltransferase 1 0.080451
LSAMP limbic system-associated membrane protein 0.0695407
NALF1 NALCN channel auxiliary factor 1 0.068129
PLPP1 phospholipid phosphatase 1 0.0646276
FMN1 formin 1 0.0643683
VCL vinculin 0.0637394
ANTXR1 anthrax toxin receptor 1 0.0561022
KLHL13 kelch-like family member 13 0.0558722
PDE4D phosphodiesterase 4D, cAMP-specific 0.0551625
PRKCA protein kinase C, alpha 0.0527132
FRMD4A FERM domain containing 4A 0.0508105
BPTF bromodomain PHD finger transcription factor 0.0498767
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.049351
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0492773
THSD4 thrombospondin, type I, domain containing 4 0.0486538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0447002
TAS2R14 taste receptor, type 2, member 14 0.0432038
GLCCI1 glucocorticoid induced 1 0.043069
RNF213 ring finger protein 213 0.0425965
VMP1 vacuole membrane protein 1 0.041299
NPAS2 neuronal PAS domain protein 2 0.0405941
FNDC3B fibronectin type III domain containing 3B 0.0405696
ZBTB20 zinc finger and BTB domain containing 20 0.0399538
SIK2 salt-inducible kinase 2 0.0384066
ZSWIM6 zinc finger, SWIM-type containing 6 0.0368289
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0367315
NKD1 naked cuticle homolog 1 (Drosophila) 0.0367133
CANX calnexin 0.0364501
EXOC4 exocyst complex component 4 0.0362697
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0358334
FHIT fragile histidine triad 0.0356857
EFNA5 ephrin-A5 0.0354224
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0349636
FNDC3A fibronectin type III domain containing 3A 0.034706
FAM107B family with sequence similarity 107, member B 0.0340475
MACF1 microtubule-actin crosslinking factor 1 0.0339244
CDH13 cadherin 13 0.0338857
LIMCH1 LIM and calponin homology domains 1 0.0338486
CUX1 cut-like homeobox 1 0.0336023
LPP LIM domain containing preferred translocation partner in lipoma 0.0332913
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0332229
RIGI RNA sensor RIG-I 0.0324922
CPED1 cadherin-like and PC-esterase domain containing 1 0.0322955
PDE10A phosphodiesterase 10A 0.0321641
RABGAP1L RAB GTPase activating protein 1-like 0.0317416
PDLIM5 PDZ and LIM domain 5 0.0317046
HIP1 huntingtin interacting protein 1 0.0310414
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0308997
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.030899
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0305289
PARD3 par-3 family cell polarity regulator 0.0304663
KCTD16 potassium channel tetramerization domain containing 16 0.0300616
TLE4 transducin-like enhancer of split 4 0.029921
WDFY3 WD repeat and FYVE domain containing 3 0.0288572
GPC5 glypican 5 0.0281754
RAD51B RAD51 paralog B 0.0279096
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0278869
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0278693
MED13 mediator complex subunit 13 0.0278316
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0276122
INTS6 integrator complex subunit 6 0.0274516
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0270699
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0268071
ASPH aspartate beta-hydroxylase 0.0266243
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0265484
RBM20 RNA binding motif protein 20 0.0265021
STAT1 signal transducer and activator of transcription 1, 91kDa 0.026361
MAPK10 mitogen-activated protein kinase 10 0.0262293
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0261211
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0260582
NF1 neurofibromin 1 0.0259978
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0259009
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0253513
PHF3 PHD finger protein 3 0.0252339
SDK1 sidekick cell adhesion molecule 1 0.0249974
GOLGB1 golgin B1 0.0249951
BCAS3 breast carcinoma amplified sequence 3 0.0248327
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0246134
GPBP1 GC-rich promoter binding protein 1 0.0244621
SENP6 SUMO1/sentrin specific peptidase 6 0.0242189
MSI2 musashi RNA-binding protein 2 0.0240287
COL4A6 collagen, type IV, alpha 6 0.0235521
MX2 MX dynamin-like GTPase 2 0.0234936
SKIL SKI-like proto-oncogene 0.0234289
MBD5 methyl-CpG binding domain protein 5 0.0233501
IGFBP5 insulin-like growth factor binding protein 5 0.0228737
FBXO11 F-box protein 11 0.0228594
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0228593
TBC1D22A TBC1 domain family, member 22A 0.0226961
SP100 SP100 nuclear antigen 0.0226925
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0226771
CEMIP2 cell migration inducing hyaluronidase 2 0.0225449
PACS1 phosphofurin acidic cluster sorting protein 1 0.0223639
ERRFI1 ERBB receptor feedback inhibitor 1 0.0221183
STK38L serine/threonine kinase 38 like 0.0220195
GREM2 gremlin 2, DAN family BMP antagonist 0.0219058
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0218902
FAM193A family with sequence similarity 193, member A 0.0216896

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.365749
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.229537
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.186229
PTMA prothymosin, alpha -0.0729395
RPL23 ribosomal protein L23 -0.0577454
RPL19 ribosomal protein L19 -0.0552206
VIM vimentin -0.0546729
MAP1B microtubule-associated protein 1B -0.0493987
RPS6 ribosomal protein S6 -0.0471126
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0433351
TMSB10 thymosin beta 10 -0.0429677
RPL34 ribosomal protein L34 -0.0412064
NDRG1 N-myc downstream regulated 1 -0.0406626
RPS24 ribosomal protein S24 -0.0391091
RPLP1 ribosomal protein, large, P1 -0.0383081
COL1A1 collagen, type I, alpha 1 -0.0364466
ACTG1 actin gamma 1 -0.035775
PKM pyruvate kinase, muscle -0.0357174
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0347893
EIF1 eukaryotic translation initiation factor 1 -0.0342462
RPL35A ribosomal protein L35a -0.0332843
TRIB2 tribbles pseudokinase 2 -0.0307877
NCAM2 neural cell adhesion molecule 2 -0.0301815
GNAS GNAS complex locus -0.0288092
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0282708
B2M beta-2-microglobulin -0.0272808
RPS21 ribosomal protein S21 -0.0261188
MORF4L2 mortality factor 4 like 2 -0.0259963
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.025794
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0253445
RPS19 ribosomal protein S19 -0.0249223
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0245729
RPL12 ribosomal protein L12 -0.0243842
PFN1 profilin 1 -0.0237326
RPS29 ribosomal protein S29 -0.023658
TENT5A terminal nucleotidyltransferase 5A -0.0231895
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0229384
CD36 CD36 molecule (thrombospondin receptor) -0.0227266
POTEF POTE ankyrin domain family, member F -0.0226419
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0225957
RPL31 ribosomal protein L31 -0.0224695
LCORL ligand dependent nuclear receptor corepressor-like -0.0224107
HAND2 heart and neural crest derivatives expressed 2 -0.0222586
TOB1 transducer of ERBB2, 1 -0.0221791
WAC WW domain containing adaptor with coiled-coil -0.021996
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0219412
S100A6 S100 calcium binding protein A6 -0.0218807
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0215056
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0209249
RPS27 ribosomal protein S27 -0.0208906
KDM3A lysine (K)-specific demethylase 3A -0.0208737
VEGFA vascular endothelial growth factor A -0.0207239
RPS15 ribosomal protein S15 -0.0205159
RPL7A ribosomal protein L7a -0.0204426
S100A9 S100 calcium binding protein A9 -0.0204082
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0203442
RPL27 ribosomal protein L27 -0.0202956
TPI1 triosephosphate isomerase 1 -0.0201292
PCDH9 protocadherin 9 -0.0200736
FAM13A family with sequence similarity 13, member A -0.0200516
DPH6 diphthamine biosynthesis 6 -0.0200515
ACBD3 acyl-CoA binding domain containing 3 -0.0196689
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0196447
LDHB lactate dehydrogenase B -0.0195888
FTL ferritin, light polypeptide -0.0195139
CCNL1 cyclin L1 -0.0194333
VDAC1 voltage-dependent anion channel 1 -0.0191963
RPS13 ribosomal protein S13 -0.0190421
FNBP1 formin binding protein 1 -0.0188871
PRPF8 pre-mRNA processing factor 8 -0.0188475
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0187842
RPS2 ribosomal protein S2 -0.0186106
RPL32 ribosomal protein L32 -0.0183265
MKI67 marker of proliferation Ki-67 -0.0183036
WDR45B WD repeat domain 45B -0.0181022
CDC27 cell division cycle 27 -0.0176846
RSL1D1 ribosomal L1 domain containing 1 -0.0176328
JPT1 Jupiter microtubule associated homolog 1 -0.0175287
RPLP0 ribosomal protein, large, P0 -0.0173196
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0172639
MDK midkine (neurite growth-promoting factor 2) -0.0171535
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0170814
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0170684
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0168511
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0166838
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.016641
SLC38A2 solute carrier family 38, member 2 -0.0166151
RPS25 ribosomal protein S25 -0.0164878
WSB1 WD repeat and SOCS box containing 1 -0.0164549
ATN1 atrophin 1 -0.0164114
HLA-A major histocompatibility complex, class I, A -0.0164005
WBP11 WW domain binding protein 11 -0.0163321
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.016192
HMGA1 high mobility group AT-hook 1 -0.0161559
PRR11 proline rich 11 -0.0161523
PCNX1 pecanex 1 -0.0161116
SOS1 son of sevenless homolog 1 (Drosophila) -0.0160662
RFC3 replication factor C (activator 1) 3, 38kDa -0.0160486
NPEPPS aminopeptidase puromycin sensitive -0.0158691
RPS5 ribosomal protein S5 -0.0158469