Sinomenine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sinomenine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sinomenine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.149744
CDH13 cadherin 13 0.089204
TRIO trio Rho guanine nucleotide exchange factor 0.0734695
FNDC3B fibronectin type III domain containing 3B 0.064558
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.058778
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.056563
HIPK2 homeodomain interacting protein kinase 2 0.0557652
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0551144
CADM1 cell adhesion molecule 1 0.0517328
ERRFI1 ERBB receptor feedback inhibitor 1 0.0505548
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0489762
NAV2 neuron navigator 2 0.0477443
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0475559
AHNAK AHNAK nucleoprotein 0.0474851
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0438799
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0432306
LPP LIM domain containing preferred translocation partner in lipoma 0.0388915
ZSWIM6 zinc finger, SWIM-type containing 6 0.0366271
MACF1 microtubule-actin crosslinking factor 1 0.0354601
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0329336
EGFR epidermal growth factor receptor 0.0319846
PTK2 protein tyrosine kinase 2 0.0314548
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0314013
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0305184
PRELID2 PRELI domain containing 2 0.0302812
FBN1 fibrillin 1 0.0302122
HMGA2 high mobility group AT-hook 2 0.0301514
MAP4 microtubule-associated protein 4 0.0289261
ANKRD11 ankyrin repeat domain 11 0.0282064
EFNA5 ephrin-A5 0.0281146
HDAC9 histone deacetylase 9 0.0279686
JARID2 jumonji, AT rich interactive domain 2 0.0266619
GOLGB1 golgin B1 0.0256943
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0253824
ATXN1 ataxin 1 0.0253474
FMNL2 formin-like 2 0.0249273
ZBTB38 zinc finger and BTB domain containing 38 0.0245328
FNIP1 folliculin interacting protein 1 0.0244789
ZFAND3 zinc finger, AN1-type domain 3 0.0236585
PDIA5 protein disulfide isomerase family A, member 5 0.0232309
ASPH aspartate beta-hydroxylase 0.0231277
MYH9 myosin, heavy chain 9, non-muscle 0.0227399
PICALM phosphatidylinositol binding clathrin assembly protein 0.0225912
DST dystonin 0.0225722
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0221205
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0213268
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0212182
MED13L mediator complex subunit 13-like 0.0211717
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0209232
PTPRG protein tyrosine phosphatase, receptor type, G 0.0204094
IL6ST interleukin 6 signal transducer 0.0202951
SMYD3 SET and MYND domain containing 3 0.0201401
SP100 SP100 nuclear antigen 0.0198225
FBXL7 F-box and leucine-rich repeat protein 7 0.0196963
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0196578
SQSTM1 sequestosome 1 0.0196098
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.019592
COL5A1 collagen, type V, alpha 1 0.0195342
INTS6 integrator complex subunit 6 0.0193074
EPS8 epidermal growth factor receptor pathway substrate 8 0.0193062
EXOC4 exocyst complex component 4 0.0189663
EXT1 exostosin glycosyltransferase 1 0.0189376
NAV1 neuron navigator 1 0.0187139
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0186027
PTPRM protein tyrosine phosphatase, receptor type, M 0.0184284
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0183834
PSD3 pleckstrin and Sec7 domain containing 3 0.0183399
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0183212
ANKHD1 ankyrin repeat and KH domain containing 1 0.0181408
NALF1 NALCN channel auxiliary factor 1 0.017887
COL7A1 collagen, type VII, alpha 1 0.0177125
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0176572
APP amyloid beta (A4) precursor protein 0.0174491
JAK1 Janus kinase 1 0.017405
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.017351
DOCK5 dedicator of cytokinesis 5 0.0173442
UTRN utrophin 0.0172944
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0172562
SOD2 superoxide dismutase 2, mitochondrial 0.0172094
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0172092
CAMTA1 calmodulin binding transcription activator 1 0.0172069
PLEC plectin 0.0171933
CCNY cyclin Y 0.0170896
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0170239
SAMD4A sterile alpha motif domain containing 4A 0.0165195
FER fer (fps/fes related) tyrosine kinase 0.0162996
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0161115
CDK13 cyclin-dependent kinase 13 0.0161046
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0160839
SPDYA speedy/RINGO cell cycle regulator family member A 0.01607
CTBP2 C-terminal binding protein 2 0.016059
OGA O-GlcNAcase 0.0160274
ZEB1 zinc finger E-box binding homeobox 1 0.0157847
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0156475
ZCCHC7 zinc finger, CCHC domain containing 7 0.0155431
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0154747
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0153644
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0153018
AGO2 argonaute RISC catalytic component 2 0.0152865
CUX1 cut-like homeobox 1 0.0152007

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.25302
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22224
VIM vimentin -0.222167
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.17003
MT2A metallothionein 2A -0.168389
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.155682
TMSB10 thymosin beta 10 -0.122854
FN1 fibronectin 1 -0.108795
COL1A1 collagen, type I, alpha 1 -0.101039
NDRG1 N-myc downstream regulated 1 -0.0876977
COL1A2 collagen, type I, alpha 2 -0.0813266
CD44 CD44 molecule (Indian blood group) -0.0697591
FTL ferritin, light polypeptide -0.063654
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0617224
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0504262
LGALS1 lectin, galactoside-binding, soluble, 1 -0.047625
PTMA prothymosin, alpha -0.0451921
B2M beta-2-microglobulin -0.0445997
S100A9 S100 calcium binding protein A9 -0.0420912
TGFBI transforming growth factor, beta-induced, 68kDa -0.0406682
TPM4 tropomyosin 4 -0.0405262
RPS6 ribosomal protein S6 -0.0395585
TM4SF1 transmembrane 4 L six family member 1 -0.0375876
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0373143
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0366085
RPS8 ribosomal protein S8 -0.0364061
RPL35A ribosomal protein L35a -0.0360444
HLA-B major histocompatibility complex, class I, B -0.0358297
STC1 stanniocalcin 1 -0.0357427
EIF1 eukaryotic translation initiation factor 1 -0.0355485
RPS19 ribosomal protein S19 -0.0329556
PFN1 profilin 1 -0.0328231
MT1X metallothionein 1X -0.0327951
EGR1 early growth response 1 -0.0317787
ACTG1 actin gamma 1 -0.0309051
LDHA lactate dehydrogenase A -0.0294222
LOC112694756 uncharaterized LOC112694756 -0.0287804
FTH1 ferritin, heavy polypeptide 1 -0.0282164
CYB5R3 cytochrome b5 reductase 3 -0.0281216
S100A6 S100 calcium binding protein A6 -0.0279252
RPL23 ribosomal protein L23 -0.027899
IFI6 interferon, alpha-inducible protein 6 -0.0273657
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0271432
RPL8 ribosomal protein L8 -0.0270771
POTEF POTE ankyrin domain family, member F -0.0261667
VCAN versican -0.025744
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0253448
ENO1 enolase 1, (alpha) -0.0251157
HMGA1 high mobility group AT-hook 1 -0.0246799
HLA-A major histocompatibility complex, class I, A -0.0243959
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0243274
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0241679
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0240091
MAP1B microtubule-associated protein 1B -0.0237674
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0233668
IGFBP7 insulin-like growth factor binding protein 7 -0.0233374
CALD1 caldesmon 1 -0.0228978
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.022804
RPL36 ribosomal protein L36 -0.0227542
IER3 immediate early response 3 -0.0225886
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0222228
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0221555
CALR calreticulin -0.0220382
IFITM3 interferon induced transmembrane protein 3 -0.0216741
TPI1 triosephosphate isomerase 1 -0.0216211
IL6 interleukin 6 -0.0215648
RPL19 ribosomal protein L19 -0.0215567
RPLP1 ribosomal protein, large, P1 -0.0213311
VEGFA vascular endothelial growth factor A -0.0210884
S100A10 S100 calcium binding protein A10 -0.0210633
RPL12 ribosomal protein L12 -0.0206562
PLAUR plasminogen activator, urokinase receptor -0.0203126
PKM pyruvate kinase, muscle -0.0200254
TAGLN2 transgelin 2 -0.0197212
RPL28 ribosomal protein L28 -0.0196082
POSTN periostin, osteoblast specific factor -0.019583
TAPBP TAP binding protein (tapasin) -0.0192873
RPS11 ribosomal protein S11 -0.0192732
RPL32 ribosomal protein L32 -0.0191726
F3 coagulation factor III (thromboplastin, tissue factor) -0.0188613
RPL11 ribosomal protein L11 -0.0185117
RPL30 ribosomal protein L30 -0.0184674
BSG basigin (Ok blood group) -0.0179598
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0178179
DPYSL3 dihydropyrimidinase-like 3 -0.0178018
RPS13 ribosomal protein S13 -0.0176296
EEF2 eukaryotic translation elongation factor 2 -0.0173303
RPS3 ribosomal protein S3 -0.0172395
TPM2 tropomyosin 2 (beta) -0.0172314
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0171488
LMAN1 lectin, mannose-binding, 1 -0.0168359
RPL7 ribosomal protein L7 -0.0166628
LOX lysyl oxidase -0.016655
RPLP2 ribosomal protein, large, P2 -0.0163672
RPS14 ribosomal protein S14 -0.0163559
TUBB tubulin, beta class I -0.0160951
AXL AXL receptor tyrosine kinase -0.0156166
INHBA inhibin, beta A -0.0156112
LOXL2 lysyl oxidase-like 2 -0.0154845
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0154272