| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sinomenine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sinomenine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.140094 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.127551 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.079781 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0765034 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0632142 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0612883 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0603616 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0596479 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0581929 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0572535 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0513927 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0495542 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.045888 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0458463 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.043084 |
| USP34 | ubiquitin specific peptidase 34 | 0.0395134 |
| DSCAM | Down syndrome cell adhesion molecule | 0.039373 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0392756 |
| C3 | complement component 3 | 0.0383377 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0381557 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0378596 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0377555 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0368104 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0360754 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0348819 |
| AFDN | afadin, adherens junction formation factor | 0.0336268 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0331274 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0326746 |
| SVIL | supervillin | 0.0325202 |
| DSPP | dentin sialophosphoprotein | 0.0319463 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0316445 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0314747 |
| HELZ | helicase with zinc finger | 0.030385 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0298687 |
| AHNAK | AHNAK nucleoprotein | 0.0290938 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0284946 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0284662 |
| SMAD3 | SMAD family member 3 | 0.0284261 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0284219 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0282884 |
| WWC2 | WW and C2 domain containing 2 | 0.028198 |
| COPA | coatomer protein complex, subunit alpha | 0.0280978 |
| FAM107B | family with sequence similarity 107, member B | 0.0278774 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0272823 |
| GOLGA4 | golgin A4 | 0.0271121 |
| ANO6 | anoctamin 6 | 0.0269261 |
| CCNY | cyclin Y | 0.0267147 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.026614 |
| LDHA | lactate dehydrogenase A | 0.0263918 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0261877 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0261694 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0261404 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0259284 |
| ATXN1 | ataxin 1 | 0.0258599 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0252559 |
| KYNU | kynureninase | 0.0251283 |
| PTK2 | protein tyrosine kinase 2 | 0.0248003 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0244788 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0243628 |
| MATR3 | matrin 3 | 0.0242605 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0240098 |
| ZNF638 | zinc finger protein 638 | 0.0236278 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0236182 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0235594 |
| SEPTIN9 | septin 9 | 0.023423 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0232 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0227554 |
| FRMD5 | FERM domain containing 5 | 0.0227281 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.022675 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0226691 |
| PDE8A | phosphodiesterase 8A | 0.0226275 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0225744 |
| RAI14 | retinoic acid induced 14 | 0.022519 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0224565 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0222938 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0221074 |
| NBEAL1 | neurobeachin-like 1 | 0.0220516 |
| SEC24D | SEC24 family member D | 0.0218123 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0217238 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0216975 |
| YBX1 | Y box binding protein 1 | 0.0216465 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0215939 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0213129 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0213066 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.021255 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0212363 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0211813 |
| PHKB | phosphorylase kinase, beta | 0.0211801 |
| RAB10 | RAB10, member RAS oncogene family | 0.0211707 |
| RPL3 | ribosomal protein L3 | 0.0211654 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0209443 |
| OGA | O-GlcNAcase | 0.0209121 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0209068 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.020799 |
| PKM | pyruvate kinase, muscle | 0.0207674 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0206014 |
| CANX | calnexin | 0.0205912 |
| NUP58 | nucleoporin 58 | 0.0205902 |
| NBAS | neuroblastoma amplified sequence | 0.0205575 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0204908 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.386394 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.1051 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0992973 |
| GPC6 | glypican 6 | -0.0881752 |
| APOB | apolipoprotein B | -0.0743622 |
| TMSB10 | thymosin beta 10 | -0.0693874 |
| GPC3 | glypican 3 | -0.0559463 |
| RPS24 | ribosomal protein S24 | -0.0550682 |
| FN1 | fibronectin 1 | -0.0549573 |
| CP | ceruloplasmin (ferroxidase) | -0.0539721 |
| APOA2 | apolipoprotein A-II | -0.052192 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0517618 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0514895 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0443843 |
| NPAS2 | neuronal PAS domain protein 2 | -0.043885 |
| EGR1 | early growth response 1 | -0.0438843 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0438227 |
| VCL | vinculin | -0.0426577 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0409397 |
| ITGAV | integrin, alpha V | -0.0407029 |
| TRIM26 | tripartite motif containing 26 | -0.0383253 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0382601 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0375758 |
| OSMR | oncostatin M receptor | -0.0372452 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0365129 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0352419 |
| RNF213 | ring finger protein 213 | -0.0351963 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.033404 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0325847 |
| HMGA1 | high mobility group AT-hook 1 | -0.0319037 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0312409 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0293645 |
| RIGI | RNA sensor RIG-I | -0.0288201 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0287395 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.028475 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0279121 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0273998 |
| A2M | alpha-2-macroglobulin | -0.0269575 |
| MRTFA | myocardin related transcription factor A | -0.0267294 |
| RPLP2 | ribosomal protein, large, P2 | -0.0267039 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0257001 |
| RPL37A | ribosomal protein L37a | -0.0254889 |
| RPL35A | ribosomal protein L35a | -0.0253961 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0252202 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0251814 |
| RPS12 | ribosomal protein S12 | -0.0251356 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0248603 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0241198 |
| CRLS1 | cardiolipin synthase 1 | -0.024059 |
| CTSB | cathepsin B | -0.0236379 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0234494 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0234247 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0228838 |
| RPS21 | ribosomal protein S21 | -0.0224741 |
| AHSG | alpha-2-HS-glycoprotein | -0.0219467 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0218631 |
| RHOB | ras homolog family member B | -0.0212197 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0205386 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0204525 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0203135 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0203039 |
| RPL31 | ribosomal protein L31 | -0.02018 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0193321 |
| RPL23 | ribosomal protein L23 | -0.0192343 |
| TMEM123 | transmembrane protein 123 | -0.0191592 |
| AHR | aryl hydrocarbon receptor | -0.01915 |
| RPL26 | ribosomal protein L26 | -0.0190506 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0189351 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0189298 |
| PLSCR1 | phospholipid scramblase 1 | -0.0186896 |
| FILIP1L | filamin A interacting protein 1-like | -0.0185488 |
| RPL9 | ribosomal protein L9 | -0.0183128 |
| ACTG1 | actin gamma 1 | -0.0182993 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0180361 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0178566 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0178314 |
| VCAN | versican | -0.0176439 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.017412 |
| JAG1 | jagged 1 | -0.0173215 |
| KLF6 | Kruppel-like factor 6 | -0.0171945 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.0170793 |
| CFB | complement factor B | -0.0169148 |
| TF | transferrin | -0.0168681 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0165621 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0163869 |
| RPL34 | ribosomal protein L34 | -0.0163628 |
| MX2 | MX dynamin-like GTPase 2 | -0.0163081 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0162001 |
| MT2A | metallothionein 2A | -0.0161577 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0158662 |
| RPS15 | ribosomal protein S15 | -0.0156386 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0156191 |
| CALD1 | caldesmon 1 | -0.0154612 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0154449 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0154293 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0154008 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0153684 |
| FRK | fyn-related Src family tyrosine kinase | -0.0153113 |
| NPR2 | natriuretic peptide receptor 2 | -0.0152129 |
| ZNF503 | zinc finger protein 503 | -0.0151407 |
