Sinomenine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sinomenine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sinomenine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.245487
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.1966
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.163244
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0888479
LDHA lactate dehydrogenase A 0.0854904
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0628513
AFF1 AF4/FMR2 family, member 1 0.0609989
FAT1 FAT atypical cadherin 1 0.0562335
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0554378
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0542349
HSPA8 heat shock 70kDa protein 8 0.0501886
KRT18 keratin 18, type I 0.0490444
DSPP dentin sialophosphoprotein 0.0474683
MYO1E myosin IE 0.0444846
CANX calnexin 0.0441501
ENO1 enolase 1, (alpha) 0.0428615
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0428528
RPS8 ribosomal protein S8 0.0428513
KRT8 keratin 8, type II 0.04235
LMO7 LIM domain 7 0.0422152
CALR calreticulin 0.0409367
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0402057
AGR2 anterior gradient 2 0.03946
KLF5 Kruppel-like factor 5 (intestinal) 0.0377112
EXT1 exostosin glycosyltransferase 1 0.0368006
B2M beta-2-microglobulin 0.0356786
TGFBR3 transforming growth factor, beta receptor III 0.0355486
PDZD8 PDZ domain containing 8 0.0349693
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0338348
RPS25 ribosomal protein S25 0.0336695
PDIA4 protein disulfide isomerase family A, member 4 0.0329645
PDIA3 protein disulfide isomerase family A, member 3 0.0328772
APP amyloid beta (A4) precursor protein 0.0323307
N4BP2L2 NEDD4 binding protein 2-like 2 0.0323022
KTN1 kinectin 1 (kinesin receptor) 0.0322133
SQSTM1 sequestosome 1 0.0315159
UBC ubiquitin C 0.0313707
MUC17 mucin 17, cell surface associated 0.0306492
GOLGB1 golgin B1 0.0294967
DSTN destrin (actin depolymerizing factor) 0.0283966
MARCHF3 membrane associated ring-CH-type finger 3 0.0280884
RIGI RNA sensor RIG-I 0.0280505
TMC5 transmembrane channel-like 5 0.026222
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0260803
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0260058
PDE4D phosphodiesterase 4D, cAMP-specific 0.0259017
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0258303
RPS27A ribosomal protein S27a 0.025728
TMSB4X thymosin beta 4, X-linked 0.0255605
TPM4 tropomyosin 4 0.0252952
RPLP1 ribosomal protein, large, P1 0.0252863
RPL7A ribosomal protein L7a 0.0252563
RPL3 ribosomal protein L3 0.0249873
S100A6 S100 calcium binding protein A6 0.0249681
ZBTB20 zinc finger and BTB domain containing 20 0.0249185
CLCN3 chloride channel, voltage-sensitive 3 0.0249106
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0246196
NUCB2 nucleobindin 2 0.0245936
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02439
CCND1 cyclin D1 0.0243809
GCLC glutamate-cysteine ligase, catalytic subunit 0.0239722
TFF1 trefoil factor 1 0.0237533
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0236446
UNC13B unc-13 homolog B (C. elegans) 0.0232901
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0232465
PKM pyruvate kinase, muscle 0.0232316
RPS16 ribosomal protein S16 0.02319
MTDH metadherin 0.0227809
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0226528
RPS27 ribosomal protein S27 0.0225289
RPL4 ribosomal protein L4 0.0220627
IQGAP1 IQ motif containing GTPase activating protein 1 0.021547
FTL ferritin, light polypeptide 0.0215271
NEBL nebulette 0.0214771
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0213471
KIF5B kinesin family member 5B 0.0209098
RPL39 ribosomal protein L39 0.0207648
RPL27A ribosomal protein L27a 0.0206919
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.02055
DUSP16 dual specificity phosphatase 16 0.0202226
AHNAK AHNAK nucleoprotein 0.0201506
SMAD2 SMAD family member 2 0.0201109
LGALS3 lectin, galactoside-binding, soluble, 3 0.0198207
TMCO3 transmembrane and coiled-coil domains 3 0.0197039
CEMIP2 cell migration inducing hyaluronidase 2 0.0195886
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0195294
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0194851
RPL7 ribosomal protein L7 0.0192923
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0192041
SSR1 signal sequence receptor, alpha 0.018828
PNRC1 proline-rich nuclear receptor coactivator 1 0.0186384
RPS2 ribosomal protein S2 0.0186383
UBL3 ubiquitin-like 3 0.018636
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0184913
EGFR epidermal growth factor receptor 0.0183978
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0183174
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0183102
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.01826
TUBA1B tubulin, alpha 1b 0.0182543
RPS23 ribosomal protein S23 0.0182235

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.151216
NPSR1 neuropeptide S receptor 1 -0.133481
VCL vinculin -0.133232
PTMA prothymosin, alpha -0.122515
TMSB10 thymosin beta 10 -0.111693
CEMIP cell migration inducing protein, hyaluronan binding -0.0999535
FLNB filamin B, beta -0.0914761
GPHN gephyrin -0.0725471
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.072522
AREG amphiregulin -0.0721538
ONECUT3 one cut homeobox 3 -0.0673412
ACTN4 actinin, alpha 4 -0.0646759
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0642176
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0633957
NCOR1 nuclear receptor corepressor 1 -0.0629446
LAMA4 laminin, alpha 4 -0.0616633
GMDS GDP-mannose 4,6-dehydratase -0.0612613
TNS4 tensin 4 -0.0578995
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0564703
NALF1 NALCN channel auxiliary factor 1 -0.0556759
ANXA2 annexin A2 -0.0553849
ITGA6 integrin, alpha 6 -0.0548384
UBA6 ubiquitin-like modifier activating enzyme 6 -0.053896
RAP1B RAP1B, member of RAS oncogene family -0.0527544
ESYT2 extended synaptotagmin-like protein 2 -0.051462
RNF43 ring finger protein 43 -0.0496436
FAM13A family with sequence similarity 13, member A -0.0493412
ZNF292 zinc finger protein 292 -0.0483354
BIRC6 baculoviral IAP repeat containing 6 -0.0481726
PICALM phosphatidylinositol binding clathrin assembly protein -0.0467331
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0449989
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0446436
VMP1 vacuole membrane protein 1 -0.0442579
MYH9 myosin, heavy chain 9, non-muscle -0.0434116
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0433534
PUM2 pumilio RNA-binding family member 2 -0.0415197
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0411771
MED13L mediator complex subunit 13-like -0.0410899
RBM39 RNA binding motif protein 39 -0.0403193
ZFAND3 zinc finger, AN1-type domain 3 -0.0387632
PNISR PNN-interacting serine/arginine-rich protein -0.0387394
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.038436
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0374794
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0374438
CD46 CD46 molecule, complement regulatory protein -0.0373055
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0370399
ARHGAP32 Rho GTPase activating protein 32 -0.0367588
EZR ezrin -0.0366877
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.036496
CLDN4 claudin 4 -0.0359813
LOC102724023 ES1 protein homolog, mitochondrial -0.0359131
PDLIM5 PDZ and LIM domain 5 -0.0355891
EGR1 early growth response 1 -0.035531
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0352977
STRN3 striatin, calmodulin binding protein 3 -0.0351256
KDM4C lysine (K)-specific demethylase 4C -0.0348361
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0346009
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0345486
RIC1 RAB6A GEF complex partner 1 -0.0345061
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0344986
SBF2 SET binding factor 2 -0.0344814
TXNIP thioredoxin interacting protein -0.034241
ANTXR2 anthrax toxin receptor 2 -0.034143
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0338038
SETD5 SET domain containing 5 -0.0337671
GREB1L growth regulation by estrogen in breast cancer-like -0.0336095
PRELID2 PRELI domain containing 2 -0.0332611
USP3 ubiquitin specific peptidase 3 -0.0332119
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0331997
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0326593
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0325753
PRSS3 protease, serine, 3 -0.0323904
ANKRD11 ankyrin repeat domain 11 -0.0322219
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0318978
NFIA nuclear factor I/A -0.0317487
ZMYM2 zinc finger, MYM-type 2 -0.0316829
USP34 ubiquitin specific peptidase 34 -0.0314764
CCNY cyclin Y -0.0314284
IARS1 isoleucyl-tRNA synthetase 1 -0.0312585
JUP junction plakoglobin -0.0312061
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0308576
AFDN afadin, adherens junction formation factor -0.0308038
TFG TRK-fused gene -0.0303039
ESRP1 epithelial splicing regulatory protein 1 -0.0302648
EFNB2 ephrin-B2 -0.0299003
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0296736
FHL2 four and a half LIM domains 2 -0.0293426
SFPQ splicing factor proline/glutamine-rich -0.0292164
SHB Src homology 2 domain containing adaptor protein B -0.0291746
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0289023
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0288829
GARS1 glycyl-tRNA synthetase 1 -0.0288185
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0288075
TRIM2 tripartite motif containing 2 -0.0285305
SREBF2 sterol regulatory element binding transcription factor 2 -0.0284997
PPARG peroxisome proliferator-activated receptor gamma -0.0283928
EPHA2 EPH receptor A2 -0.0282356
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0281752
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0281527
NUP58 nucleoporin 58 -0.027684