| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sinomenine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sinomenine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.218889 |
| INTS6 | integrator complex subunit 6 | 0.123224 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.116149 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.10995 |
| GRAMD1B | GRAM domain containing 1B | 0.0890892 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0887522 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0790402 |
| HOMER1 | homer scaffolding protein 1 | 0.0719632 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.066199 |
| EGFR | epidermal growth factor receptor | 0.0661228 |
| TOP1 | topoisomerase (DNA) I | 0.0654674 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.055386 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0549326 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0531738 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0527283 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0506749 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0501989 |
| ATF6 | activating transcription factor 6 | 0.0498819 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0496033 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0485818 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0474412 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0455108 |
| SMYD3 | SET and MYND domain containing 3 | 0.0447308 |
| DSCAM | Down syndrome cell adhesion molecule | 0.044583 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0443171 |
| GOLGB1 | golgin B1 | 0.0437261 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0408656 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0405616 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0405437 |
| USP34 | ubiquitin specific peptidase 34 | 0.0403579 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0400032 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0376094 |
| RAD51B | RAD51 paralog B | 0.0369075 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0362041 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0361596 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0357748 |
| SIK3 | SIK family kinase 3 | 0.0351725 |
| MCL1 | myeloid cell leukemia 1 | 0.0350668 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.034958 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0349291 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0344252 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0334735 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0332278 |
| BMP6 | bone morphogenetic protein 6 | 0.0332241 |
| SLTM | SAFB-like, transcription modulator | 0.0325284 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0323842 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.031929 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0318173 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0306657 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0304018 |
| FAM13A | family with sequence similarity 13, member A | 0.03012 |
| HMGA2 | high mobility group AT-hook 2 | 0.0295931 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0295778 |
| IRS2 | insulin receptor substrate 2 | 0.0290858 |
| ANXA1 | annexin A1 | 0.0290262 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0288412 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0285789 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0282914 |
| MOSMO | modulator of smoothened | 0.0280894 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0273271 |
| YAP1 | Yes-associated protein 1 | 0.0262873 |
| PRELID2 | PRELI domain containing 2 | 0.0260275 |
| SMAD3 | SMAD family member 3 | 0.0258904 |
| DST | dystonin | 0.0258055 |
| ATXN1 | ataxin 1 | 0.0255189 |
| DNER | delta/notch-like EGF repeat containing | 0.0254251 |
| PAPOLA | poly(A) polymerase alpha | 0.0251929 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0246774 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0245619 |
| H1-0 | H1.0 linker histone | 0.0245396 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0244164 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0243274 |
| WWOX | WW domain containing oxidoreductase | 0.0241313 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0241304 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0240179 |
| HDAC4 | histone deacetylase 4 | 0.023987 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0238808 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0238572 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0237097 |
| SLC35F5 | solute carrier family 35, member F5 | 0.023651 |
| SON | SON DNA binding protein | 0.0236074 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0231229 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0227854 |
| PYGL | phosphorylase, glycogen, liver | 0.022684 |
| NF1 | neurofibromin 1 | 0.0225589 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0224217 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0223761 |
| AEBP2 | AE binding protein 2 | 0.0223703 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0223209 |
| SPAG9 | sperm associated antigen 9 | 0.0222449 |
| ZNF638 | zinc finger protein 638 | 0.0221337 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0220386 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0219605 |
| TLE4 | transducin-like enhancer of split 4 | 0.0218897 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0217332 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0216555 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0216315 |
| AHNAK | AHNAK nucleoprotein | 0.0214777 |
| FRY | furry homolog (Drosophila) | 0.0211897 |
| GPHN | gephyrin | 0.0208802 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.281801 |
| TXNRD1 | thioredoxin reductase 1 | -0.16216 |
| TMSB10 | thymosin beta 10 | -0.147647 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.136298 |
| NDRG1 | N-myc downstream regulated 1 | -0.109263 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0813509 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.079323 |
| ASPH | aspartate beta-hydroxylase | -0.0778101 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0715037 |
| LAMC2 | laminin, gamma 2 | -0.0684558 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0663751 |
| FTL | ferritin, light polypeptide | -0.0660504 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0625375 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0623344 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0613968 |
| PKM | pyruvate kinase, muscle | -0.060029 |
| OSMR | oncostatin M receptor | -0.0588371 |
| ACTG1 | actin gamma 1 | -0.058133 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0564742 |
| CST3 | cystatin C | -0.0521808 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0519616 |
| B2M | beta-2-microglobulin | -0.0517211 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0488101 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0484972 |
| RPL35A | ribosomal protein L35a | -0.048451 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0480065 |
| PTMA | prothymosin, alpha | -0.0473049 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0457443 |
| S100A10 | S100 calcium binding protein A10 | -0.0456735 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0452207 |
| EGR1 | early growth response 1 | -0.0442537 |
| KRT7 | keratin 7, type II | -0.0423775 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0417656 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0416147 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0410829 |
| RPLP1 | ribosomal protein, large, P1 | -0.0410533 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0404154 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0395511 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0394907 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0373877 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0373432 |
| HMGA1 | high mobility group AT-hook 1 | -0.0373003 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0365032 |
| S100A6 | S100 calcium binding protein A6 | -0.0364898 |
| RPL34 | ribosomal protein L34 | -0.0363622 |
| SEC61G | Sec61 gamma subunit | -0.0362633 |
| RPS25 | ribosomal protein S25 | -0.0361317 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0355277 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.035513 |
| HLA-B | major histocompatibility complex, class I, B | -0.0339638 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0339151 |
| ANKRD12 | ankyrin repeat domain 12 | -0.033757 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0327265 |
| ANXA2 | annexin A2 | -0.0321991 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0316516 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0315721 |
| RPL37A | ribosomal protein L37a | -0.0312418 |
| PERP | PERP, TP53 apoptosis effector | -0.0307115 |
| CDCP1 | CUB domain containing protein 1 | -0.0300502 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0294185 |
| TMEM165 | transmembrane protein 165 | -0.0293783 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.028698 |
| POTEF | POTE ankyrin domain family, member F | -0.0286368 |
| KRT18 | keratin 18, type I | -0.0285091 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0276939 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0276768 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0275356 |
| RPS27 | ribosomal protein S27 | -0.0269452 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0268941 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0266178 |
| ENO1 | enolase 1, (alpha) | -0.0262951 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0262583 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0256241 |
| ARRDC3 | arrestin domain containing 3 | -0.0254483 |
| CTSL | cathepsin L | -0.0253413 |
| KRT19 | keratin 19, type I | -0.0251594 |
| RPS8 | ribosomal protein S8 | -0.0250626 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0248523 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0246041 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0245055 |
| STC1 | stanniocalcin 1 | -0.0245046 |
| PDE8A | phosphodiesterase 8A | -0.0245008 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0243691 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0242912 |
| PCED1B | PC-esterase domain containing 1B | -0.0242254 |
| LAMA4 | laminin, alpha 4 | -0.023986 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0237766 |
| TPD52 | tumor protein D52 | -0.0237254 |
| RPL37 | ribosomal protein L37 | -0.0236152 |
| RPS3 | ribosomal protein S3 | -0.0234283 |
| CAV2 | caveolin 2 | -0.0232581 |
| S100A11 | S100 calcium binding protein A11 | -0.023233 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0229025 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0220655 |
| MYO1D | myosin ID | -0.0219752 |
| RPS23 | ribosomal protein S23 | -0.0215678 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0214381 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0212382 |
| RIN2 | Ras and Rab interactor 2 | -0.021038 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0208937 |
