| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sinomenine perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sinomenine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0914474 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0705789 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0525336 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0504729 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0480075 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.046677 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0407842 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0382914 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0371922 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0367487 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0363605 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0352869 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348002 |
| KYNU | kynureninase | 0.0329729 |
| RBM39 | RNA binding motif protein 39 | 0.031496 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0311718 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0309218 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0298142 |
| COPA | coatomer protein complex, subunit alpha | 0.0293534 |
| EGFR | epidermal growth factor receptor | 0.0281205 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0276994 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0264308 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.025966 |
| GOLGA4 | golgin A4 | 0.0251693 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0244671 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0240505 |
| ATF6 | activating transcription factor 6 | 0.0236176 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0232128 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0229825 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0228028 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0227706 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0224071 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.021815 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0215147 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0212876 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0211241 |
| SETD5 | SET domain containing 5 | 0.0211155 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.02104 |
| BRD2 | bromodomain containing 2 | 0.0205599 |
| CUX1 | cut-like homeobox 1 | 0.020289 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0202794 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0199551 |
| NF1 | neurofibromin 1 | 0.0198043 |
| STK17A | serine/threonine kinase 17a | 0.0196223 |
| SMAD2 | SMAD family member 2 | 0.0195605 |
| NUMB | numb homolog (Drosophila) | 0.0193724 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0191909 |
| VCL | vinculin | 0.0191097 |
| HELZ | helicase with zinc finger | 0.0187977 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0186576 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0184238 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.018191 |
| ATXN1 | ataxin 1 | 0.0181513 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0181431 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0180962 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0179512 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0177857 |
| MYO1E | myosin IE | 0.017675 |
| USP36 | ubiquitin specific peptidase 36 | 0.0176412 |
| FMNL2 | formin-like 2 | 0.0173823 |
| RAB1A | RAB1A, member RAS oncogene family | 0.017351 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0171824 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0171531 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0169739 |
| USP47 | ubiquitin specific peptidase 47 | 0.016808 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0167941 |
| PDE10A | phosphodiesterase 10A | 0.0167693 |
| NRG1 | neuregulin 1 | 0.0166838 |
| VRK2 | vaccinia related kinase 2 | 0.0165742 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0162986 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0161407 |
| RBM6 | RNA binding motif protein 6 | 0.0160605 |
| PYGL | phosphorylase, glycogen, liver | 0.0160365 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0160001 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0158733 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0157986 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0156231 |
| NDRG1 | N-myc downstream regulated 1 | 0.0156162 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0155188 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0154783 |
| BMP6 | bone morphogenetic protein 6 | 0.0154772 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0154256 |
| DYM | dymeclin | 0.0149069 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0148656 |
| PCNX4 | pecanex 4 | 0.014844 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.014808 |
| HLA-B | major histocompatibility complex, class I, B | 0.0147824 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0147732 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0147329 |
| MRTFA | myocardin related transcription factor A | 0.0146431 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0146304 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0145982 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0145792 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0144684 |
| MAP7 | microtubule-associated protein 7 | 0.0144302 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0142058 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0141294 |
| MYO1D | myosin ID | 0.0140244 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0139713 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.01397 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.157374 |
| VIM | vimentin | -0.131873 |
| TMSB10 | thymosin beta 10 | -0.116683 |
| GRAMD1B | GRAM domain containing 1B | -0.111133 |
| RPL23 | ribosomal protein L23 | -0.10512 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.103719 |
| RPS27A | ribosomal protein S27a | -0.102082 |
| PTMA | prothymosin, alpha | -0.0889024 |
| FGB | fibrinogen beta chain | -0.0869595 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0848502 |
| TXNRD1 | thioredoxin reductase 1 | -0.0828643 |
| UBC | ubiquitin C | -0.0781046 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0773816 |
| FTL | ferritin, light polypeptide | -0.0695938 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0685439 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0620444 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0605192 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0533332 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0524081 |
| ENO1 | enolase 1, (alpha) | -0.0495444 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0494585 |
| PKM | pyruvate kinase, muscle | -0.0479944 |
| ASPH | aspartate beta-hydroxylase | -0.0467471 |
| RPL19 | ribosomal protein L19 | -0.0442088 |
| POTEF | POTE ankyrin domain family, member F | -0.041826 |
| TPM3 | tropomyosin 3 | -0.0406592 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0398333 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0394613 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0352172 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0351245 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0347881 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0342281 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0337148 |
| RPS12 | ribosomal protein S12 | -0.0325543 |
| PCBP2 | poly(rC) binding protein 2 | -0.0323959 |
| S100A6 | S100 calcium binding protein A6 | -0.0321509 |
| RPS3 | ribosomal protein S3 | -0.0311412 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0291473 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0286036 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.028587 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0280517 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0271103 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0269924 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0266536 |
| FLNA | filamin A, alpha | -0.0263034 |
| CALR | calreticulin | -0.0260632 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0259075 |
| RPS29 | ribosomal protein S29 | -0.0258971 |
| RTN4 | reticulon 4 | -0.0255258 |
| HDGF | hepatoma-derived growth factor | -0.0249874 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0247565 |
| MKI67 | marker of proliferation Ki-67 | -0.0245946 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0240283 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0239078 |
| RPL8 | ribosomal protein L8 | -0.0237787 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0237437 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0236793 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0236267 |
| AHNAK | AHNAK nucleoprotein | -0.0235711 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0234465 |
| RPL26 | ribosomal protein L26 | -0.0233766 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0233501 |
| YBX1 | Y box binding protein 1 | -0.0233235 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0228203 |
| MCL1 | myeloid cell leukemia 1 | -0.0224881 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | -0.0224073 |
| AREG | amphiregulin | -0.0223984 |
| RPL37A | ribosomal protein L37a | -0.0223162 |
| RPS8 | ribosomal protein S8 | -0.0221862 |
| THBS1 | thrombospondin 1 | -0.0221371 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0220789 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0216088 |
| LMNA | lamin A/C | -0.0212564 |
| RACK1 | receptor for activated C kinase 1 | -0.0211309 |
| RPL36 | ribosomal protein L36 | -0.0210935 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0208998 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0208884 |
| RPL15 | ribosomal protein L15 | -0.0208178 |
| RPL31 | ribosomal protein L31 | -0.0207682 |
| RPL7 | ribosomal protein L7 | -0.0207213 |
| RPLP1 | ribosomal protein, large, P1 | -0.0205809 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0201921 |
| RPL5 | ribosomal protein L5 | -0.0200778 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0199345 |
| RHOA | ras homolog family member A | -0.0199076 |
| IER3 | immediate early response 3 | -0.0196038 |
| SET | SET nuclear proto-oncogene | -0.0195589 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0194681 |
| RPL4 | ribosomal protein L4 | -0.0192756 |
| CENPF | centromere protein F, 350/400kDa | -0.019068 |
| ANLN | anillin, actin binding protein | -0.0190455 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0188543 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0187113 |
| UPP1 | uridine phosphorylase 1 | -0.0186952 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0186417 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0185574 |
| APP | amyloid beta (A4) precursor protein | -0.0184641 |
| LDHB | lactate dehydrogenase B | -0.0184599 |
| JUN | jun proto-oncogene | -0.0183834 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.0183212 |
