Sinomenine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sinomenine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sinomenine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZCCHC7 zinc finger, CCHC domain containing 7 0.0784735
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.070024
INTS6 integrator complex subunit 6 0.0557285
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0500318
COPA coatomer protein complex, subunit alpha 0.0488823
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0462192
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0444897
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0410895
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0403359
PDLIM5 PDZ and LIM domain 5 0.0403197
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0392892
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.03651
WNT2B wingless-type MMTV integration site family, member 2B 0.0357667
AEBP2 AE binding protein 2 0.0351956
BRD2 bromodomain containing 2 0.0351406
JMJD1C jumonji domain containing 1C 0.0346049
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0343464
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0329063
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0324327
HOMER1 homer scaffolding protein 1 0.0322166
PDE4D phosphodiesterase 4D, cAMP-specific 0.0321597
ZSWIM6 zinc finger, SWIM-type containing 6 0.031394
SND1 staphylococcal nuclease and tudor domain containing 1 0.0313571
AFF3 AF4/FMR2 family, member 3 0.0308482
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0305728
RAB7A RAB7A, member RAS oncogene family 0.02995
BPTF bromodomain PHD finger transcription factor 0.028318
ZNF638 zinc finger protein 638 0.0279662
ELL2 elongation factor, RNA polymerase II, 2 0.0273781
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.026491
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0259989
AKAP9 A kinase (PRKA) anchor protein 9 0.0259832
KDM2A lysine (K)-specific demethylase 2A 0.0258729
SEC31A SEC31 homolog A (S. cerevisiae) 0.0257174
GOLGB1 golgin B1 0.0257115
SFPQ splicing factor proline/glutamine-rich 0.0252057
RABGAP1L RAB GTPase activating protein 1-like 0.024788
MACF1 microtubule-actin crosslinking factor 1 0.0244999
GSK3B glycogen synthase kinase 3 beta 0.0238572
VMP1 vacuole membrane protein 1 0.0237575
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0234805
GON4L gon-4-like (C. elegans) 0.0233529
TTC3 tetratricopeptide repeat domain 3 0.0233002
ANKRD17 ankyrin repeat domain 17 0.023151
NABP1 nucleic acid binding protein 1 0.022955
TPM3 tropomyosin 3 0.022443
R3HDM2 R3H domain containing 2 0.022401
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0218162
SETD5 SET domain containing 5 0.0217005
USP34 ubiquitin specific peptidase 34 0.0216312
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0214818
TRA2A transformer 2 alpha homolog (Drosophila) 0.0212929
N4BP2L2 NEDD4 binding protein 2-like 2 0.0211813
UBN2 ubinuclein 2 0.0211524
SETX senataxin 0.0211443
GPATCH2L G patch domain containing 2-like 0.0210264
FMNL2 formin-like 2 0.0209121
SAMD4A sterile alpha motif domain containing 4A 0.0208865
ANO6 anoctamin 6 0.0207915
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0206881
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0204141
PTK2 protein tyrosine kinase 2 0.0203787
MCL1 myeloid cell leukemia 1 0.0203566
ZMYM4 zinc finger, MYM-type 4 0.0200879
PATJ PATJ crumbs cell polarity complex component 0.0200403
CDK13 cyclin-dependent kinase 13 0.0196943
AGO3 argonaute RISC catalytic component 3 0.0196217
EXOC6B exocyst complex component 6B 0.019441
FAF1 Fas (TNFRSF6) associated factor 1 0.0194356
UBAP2L ubiquitin associated protein 2-like 0.0192921
UBE3C ubiquitin protein ligase E3C 0.0191546
WNK1 WNK lysine deficient protein kinase 1 0.0190762
SCFD1 sec1 family domain containing 1 0.019006
TTC17 tetratricopeptide repeat domain 17 0.0189623
PRKCE protein kinase C, epsilon 0.0188665
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0187729
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0187141
ZNF207 zinc finger protein 207 0.0186981
NBEAL1 neurobeachin-like 1 0.0185928
DCAF8 DDB1 and CUL4 associated factor 8 0.0185752
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0182233
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0180383
YAP1 Yes-associated protein 1 0.0179789
ZNF644 zinc finger protein 644 0.0178371
RICTOR RPTOR independent companion of MTOR, complex 2 0.0176075
UBAP2 ubiquitin associated protein 2 0.0175955
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0175493
NF1 neurofibromin 1 0.0174942
MSN moesin 0.0174589
DSCAM Down syndrome cell adhesion molecule 0.0174193
TASOR2 transcription activation suppressor family member 2 0.0173644
CSNK1A1 casein kinase 1, alpha 1 0.0172187
GOSR2 golgi SNAP receptor complex member 2 0.0171416
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0169876
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0169496
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0168596
PUM1 pumilio RNA-binding family member 1 0.0167784
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0167605
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0167136
ATP13A3 ATPase type 13A3 0.0167059

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291676
TMSB10 thymosin beta 10 -0.133356
TFPI2 tissue factor pathway inhibitor 2 -0.130403
VIM vimentin -0.0997909
PTMA prothymosin, alpha -0.088119
TXNRD1 thioredoxin reductase 1 -0.0759322
TPI1 triosephosphate isomerase 1 -0.0656781
YBX3 Y box binding protein 3 -0.0613219
RPS21 ribosomal protein S21 -0.0604315
TM4SF1 transmembrane 4 L six family member 1 -0.051924
MYL12B myosin, light chain 12B, regulatory -0.0515569
ACTG1 actin gamma 1 -0.0514957
RPS8 ribosomal protein S8 -0.0504722
RPL26 ribosomal protein L26 -0.0503067
RPL35A ribosomal protein L35a -0.0483678
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0467805
RPL12 ribosomal protein L12 -0.0445899
IGF1R insulin-like growth factor 1 receptor -0.0418906
TPT1 tumor protein, translationally-controlled 1 -0.0417604
MT2A metallothionein 2A -0.0416971
RPLP1 ribosomal protein, large, P1 -0.0406501
RPL37 ribosomal protein L37 -0.0405867
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0399037
RPL23 ribosomal protein L23 -0.0396346
RPL19 ribosomal protein L19 -0.0371304
RPL34 ribosomal protein L34 -0.0365044
RPS3 ribosomal protein S3 -0.0361405
RPL38 ribosomal protein L38 -0.0360894
RPS27 ribosomal protein S27 -0.0359451
RPLP0 ribosomal protein, large, P0 -0.0354947
RPS19 ribosomal protein S19 -0.0351923
RPS12 ribosomal protein S12 -0.0336291
RPS15 ribosomal protein S15 -0.0330583
IFI6 interferon, alpha-inducible protein 6 -0.0329065
RPS29 ribosomal protein S29 -0.0326709
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0320584
RPLP2 ribosomal protein, large, P2 -0.0316046
KTN1 kinectin 1 (kinesin receptor) -0.0314682
PGK1 phosphoglycerate kinase 1 -0.0312371
PFN1 profilin 1 -0.0306925
KLF6 Kruppel-like factor 6 -0.0296218
BASP1 brain abundant, membrane attached signal protein 1 -0.0295318
RPL8 ribosomal protein L8 -0.029141
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0289244
RPS27A ribosomal protein S27a -0.0288372
RPS24 ribosomal protein S24 -0.0288207
RPL32 ribosomal protein L32 -0.0286115
RPL36 ribosomal protein L36 -0.0280402
NAP1L1 nucleosome assembly protein 1-like 1 -0.0278524
GNAS GNAS complex locus -0.0277582
HLA-B major histocompatibility complex, class I, B -0.0270034
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.026565
RPL37A ribosomal protein L37a -0.0265487
ATP5F1E ATP synthase F1 subunit epsilon -0.0262136
RPS4X ribosomal protein S4, X-linked -0.0261379
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0259995
RPL9 ribosomal protein L9 -0.0259478
VDAC1 voltage-dependent anion channel 1 -0.0258717
CSDE1 cold shock domain containing E1, RNA-binding -0.0256201
MIS18BP1 MIS18 binding protein 1 -0.0251889
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0251363
LDHB lactate dehydrogenase B -0.0248108
GSTP1 glutathione S-transferase pi 1 -0.0246307
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0244138
RPL31 ribosomal protein L31 -0.0242985
RPL11 ribosomal protein L11 -0.0242656
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0240226
KDM3A lysine (K)-specific demethylase 3A -0.0237
LOC112694756 uncharaterized LOC112694756 -0.02351
RACK1 receptor for activated C kinase 1 -0.0234956
RPS6 ribosomal protein S6 -0.023035
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.022853
BSG basigin (Ok blood group) -0.0227595
SSB Sjogren syndrome antigen B (autoantigen La) -0.0226266
FTL ferritin, light polypeptide -0.022352
RPL5 ribosomal protein L5 -0.0222499
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0221789
KRT18 keratin 18, type I -0.0221458
UBB ubiquitin B -0.0219491
BZW1 basic leucine zipper and W2 domains 1 -0.021931
RPS10 ribosomal protein S10 -0.0218922
RPL35 ribosomal protein L35 -0.021725
S100A6 S100 calcium binding protein A6 -0.0217172
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0216469
CBX3 chromobox homolog 3 -0.0216178
DEK DEK proto-oncogene -0.0216145
CCND2 cyclin D2 -0.0215791
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0213942
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.021163
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0211388
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0206453
S100A10 S100 calcium binding protein A10 -0.0205206
TUBB tubulin, beta class I -0.0204539
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.02033
RPL27 ribosomal protein L27 -0.0202551
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0200102
OSMR oncostatin M receptor -0.019976
RPS14 ribosomal protein S14 -0.0195022
RPS17 ribosomal protein S17 -0.0193522
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.019134