| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sinomenine perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sinomenine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC22D2 | TSC22 domain family, member 2 | 0.140918 |
| HDAC9 | histone deacetylase 9 | 0.12591 |
| ZNF292 | zinc finger protein 292 | 0.0872372 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0843518 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0688322 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0612356 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0490885 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0489564 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0485565 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0485153 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0482031 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0473026 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0467893 |
| USP3 | ubiquitin specific peptidase 3 | 0.045828 |
| USP53 | ubiquitin specific peptidase 53 | 0.0418242 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0413273 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0403599 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0399764 |
| MED13L | mediator complex subunit 13-like | 0.038906 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0386257 |
| FOXP2 | forkhead box P2 | 0.0381339 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0375016 |
| NCKAP1 | NCK-associated protein 1 | 0.0359047 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0358717 |
| YAP1 | Yes-associated protein 1 | 0.035354 |
| HBS1L | HBS1-like translational GTPase | 0.0348478 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0344256 |
| COL5A2 | collagen, type V, alpha 2 | 0.0343283 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0341014 |
| H1-0 | H1.0 linker histone | 0.0340333 |
| OGA | O-GlcNAcase | 0.0326567 |
| FBXO11 | F-box protein 11 | 0.0321063 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0320337 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0316567 |
| MYO10 | myosin X | 0.0316423 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0315766 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.031351 |
| CDC73 | cell division cycle 73 | 0.0313439 |
| WWC2 | WW and C2 domain containing 2 | 0.0313019 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0312764 |
| NUP58 | nucleoporin 58 | 0.031051 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0306743 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0306356 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0304039 |
| APP | amyloid beta (A4) precursor protein | 0.0303325 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0299717 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0298662 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0291055 |
| MEF2A | myocyte enhancer factor 2A | 0.0285802 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0284992 |
| MTF2 | metal response element binding transcription factor 2 | 0.0283403 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0282229 |
| NFIA | nuclear factor I/A | 0.0279982 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0275165 |
| MEMO1 | mediator of cell motility 1 | 0.0274736 |
| CDH19 | cadherin 19, type 2 | 0.0274313 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0274041 |
| TRIM33 | tripartite motif containing 33 | 0.0272214 |
| DENND4A | DENN/MADD domain containing 4A | 0.026693 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0263903 |
| XPO1 | exportin 1 | 0.0263488 |
| ANK2 | ankyrin 2, neuronal | 0.0262187 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0259827 |
| JMJD1C | jumonji domain containing 1C | 0.0256104 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.025415 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0252878 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0249117 |
| PDS5B | PDS5 cohesin associated factor B | 0.024726 |
| EFNA5 | ephrin-A5 | 0.024662 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0244589 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0242881 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0242771 |
| FOXO1 | forkhead box O1 | 0.0241486 |
| SIK3 | SIK family kinase 3 | 0.0240601 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.023759 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0237565 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0236419 |
| PTK2 | protein tyrosine kinase 2 | 0.0234526 |
| USP8 | ubiquitin specific peptidase 8 | 0.0234052 |
| DMXL1 | Dmx-like 1 | 0.023383 |
| MYO6 | myosin VI | 0.0232793 |
| XPO6 | exportin 6 | 0.0232473 |
| RYBP | RING1 and YY1 binding protein | 0.0231862 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0231563 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0231132 |
| RHEB | Ras homolog enriched in brain | 0.0229296 |
| RHOH | ras homolog family member H | 0.0225852 |
| QKI | QKI, KH domain containing, RNA binding | 0.0224291 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0224247 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0223972 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0223401 |
| PRKD1 | protein kinase D1 | 0.022281 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0221962 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.022178 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0221429 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0218421 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0217074 |
| MSN | moesin | 0.021572 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0215538 |
| PREPL | prolyl endopeptidase-like | 0.0214914 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.184971 |
| VIM | vimentin | -0.183485 |
| COL11A1 | collagen, type XI, alpha 1 | -0.160088 |
| CADM2 | cell adhesion molecule 2 | -0.127536 |
| PTMA | prothymosin, alpha | -0.0982317 |
| COL1A2 | collagen, type I, alpha 2 | -0.0879652 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0874614 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0807621 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0805805 |
| RPL35A | ribosomal protein L35a | -0.078853 |
| RPS8 | ribosomal protein S8 | -0.0766731 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0716888 |
| GPC3 | glypican 3 | -0.0681373 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0670012 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0655228 |
| RPS16 | ribosomal protein S16 | -0.0648919 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0598659 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0573838 |
| NTM | neurotrimin | -0.0535609 |
| RPL23 | ribosomal protein L23 | -0.0521489 |
| TENM3 | teneurin transmembrane protein 3 | -0.0504606 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0503444 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0503097 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0499694 |
| ITGAV | integrin, alpha V | -0.048886 |
| ACTG1 | actin gamma 1 | -0.0476869 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0466224 |
| RPL31 | ribosomal protein L31 | -0.0461234 |
| MAP4 | microtubule-associated protein 4 | -0.0448759 |
| RAI1 | retinoic acid induced 1 | -0.0447167 |
| CENPF | centromere protein F, 350/400kDa | -0.0446122 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0444695 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0435399 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0434254 |
| RPS25 | ribosomal protein S25 | -0.0427681 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0426206 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0423057 |
| THOC2 | THO complex 2 | -0.0422568 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.041733 |
| MEIS2 | Meis homeobox 2 | -0.0406814 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0403243 |
| HMCN1 | hemicentin 1 | -0.0402902 |
| RPS6 | ribosomal protein S6 | -0.0400271 |
| SNX6 | sorting nexin 6 | -0.0395532 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0394491 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.039043 |
| UPP1 | uridine phosphorylase 1 | -0.0387537 |
| RPL36A | ribosomal protein L36a | -0.0382286 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0378395 |
| RPS13 | ribosomal protein S13 | -0.0377062 |
| DEK | DEK proto-oncogene | -0.0377051 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0364136 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0362917 |
| SERF2 | small EDRK-rich factor 2 | -0.0356885 |
| NRG1 | neuregulin 1 | -0.0356428 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0344501 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0341025 |
| S100A9 | S100 calcium binding protein A9 | -0.0339411 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0338272 |
| S100A10 | S100 calcium binding protein A10 | -0.0333044 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.032846 |
| PHIP | pleckstrin homology domain interacting protein | -0.0327982 |
| RPL11 | ribosomal protein L11 | -0.0327095 |
| SMIM44 | small integral membrane protein 44 | -0.0321691 |
| LRRC4C | leucine rich repeat containing 4C | -0.0317335 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0313086 |
| FTL | ferritin, light polypeptide | -0.031227 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0309785 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.030676 |
| LYST | lysosomal trafficking regulator | -0.0305166 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0304617 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0304271 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0304129 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0302423 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0301962 |
| CALR | calreticulin | -0.0300739 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0300426 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0297547 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.0297492 |
| TOX | thymocyte selection-associated high mobility group box | -0.029576 |
| PFN1 | profilin 1 | -0.0293488 |
| RPS12 | ribosomal protein S12 | -0.0289966 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0289829 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0287705 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0284952 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0284886 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0284281 |
| RPL5 | ribosomal protein L5 | -0.028315 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.028054 |
| GNAS | GNAS complex locus | -0.0280285 |
| PCDH9 | protocadherin 9 | -0.0279843 |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | -0.0279255 |
| FBXO17 | F-box protein 17 | -0.0278102 |
| ENO1 | enolase 1, (alpha) | -0.027746 |
| KIF4A | kinesin family member 4A | -0.0266938 |
| EXOC4 | exocyst complex component 4 | -0.026424 |
| PRKAR2A | protein kinase, cAMP-dependent, regulatory, type II, alpha | -0.0263681 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0263561 |
| RPS14 | ribosomal protein S14 | -0.0263198 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0262992 |
