Sinomenine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sinomenine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sinomenine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0876943
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0790546
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0750318
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0680424
EPS8 epidermal growth factor receptor pathway substrate 8 0.063733
RNF145 ring finger protein 145 0.0594139
ELL2 elongation factor, RNA polymerase II, 2 0.0535631
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0489557
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0486719
FNDC3A fibronectin type III domain containing 3A 0.0471734
TXNIP thioredoxin interacting protein 0.0457265
FNDC3B fibronectin type III domain containing 3B 0.0425451
ANKRD28 ankyrin repeat domain 28 0.0404567
JMJD1C jumonji domain containing 1C 0.0401387
NEK7 NIMA-related kinase 7 0.0381206
FAM13A family with sequence similarity 13, member A 0.037796
HIPK2 homeodomain interacting protein kinase 2 0.0374076
LTBP1 latent transforming growth factor beta binding protein 1 0.0373243
FMNL2 formin-like 2 0.0370434
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0364049
WAC WW domain containing adaptor with coiled-coil 0.0358068
RICTOR RPTOR independent companion of MTOR, complex 2 0.0344539
ERBIN erbb2 interacting protein 0.0342176
NPAS2 neuronal PAS domain protein 2 0.0341507
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.034004
UBE2H ubiquitin-conjugating enzyme E2H 0.0338644
ESYT2 extended synaptotagmin-like protein 2 0.0331345
ZC3H12C zinc finger CCCH-type containing 12C 0.0330285
MBNL1 muscleblind-like splicing regulator 1 0.0329772
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0325828
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0325475
XPO1 exportin 1 0.0322482
PDLIM5 PDZ and LIM domain 5 0.0318969
KMT2C lysine (K)-specific methyltransferase 2C 0.0315176
KMT2E lysine (K)-specific methyltransferase 2E 0.0307845
CDC73 cell division cycle 73 0.0307085
ERRFI1 ERBB receptor feedback inhibitor 1 0.0306777
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0305574
SIRT1 sirtuin 1 0.0305221
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0301141
CARD16 caspase recruitment domain family, member 16 0.0298696
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0298444
PDE4D phosphodiesterase 4D, cAMP-specific 0.0297793
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0295247
QKI QKI, KH domain containing, RNA binding 0.0293389
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0290266
PARD3 par-3 family cell polarity regulator 0.0287746
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0286631
FNIP1 folliculin interacting protein 1 0.0285555
TTC3 tetratricopeptide repeat domain 3 0.0285285
ATF6 activating transcription factor 6 0.0284593
NTN4 netrin 4 0.0282917
ATXN1 ataxin 1 0.028201
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0281541
HELZ helicase with zinc finger 0.0280517
TGFB2 transforming growth factor, beta 2 0.0280392
PTK2 protein tyrosine kinase 2 0.0278006
IL6ST interleukin 6 signal transducer 0.0275907
NPTN neuroplastin 0.0274911
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0271678
KDM6A lysine (K)-specific demethylase 6A 0.0270903
GLS2 glutaminase 2 (liver, mitochondrial) 0.0268448
GPHN gephyrin 0.0265209
OGA O-GlcNAcase 0.0264273
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0263773
YAP1 Yes-associated protein 1 0.0261875
IRS2 insulin receptor substrate 2 0.0259679
DSCAM Down syndrome cell adhesion molecule 0.0258933
PUM2 pumilio RNA-binding family member 2 0.0253028
RAB10 RAB10, member RAS oncogene family 0.0252985
AKAP13 A kinase (PRKA) anchor protein 13 0.0251813
SAMD4A sterile alpha motif domain containing 4A 0.0251192
ETNK1 ethanolamine kinase 1 0.0250274
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0250258
PRRC2C proline-rich coiled-coil 2C 0.0250152
ZNF292 zinc finger protein 292 0.0247183
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0246873
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0244958
SSBP2 single-stranded DNA binding protein 2 0.0243533
TOP1 topoisomerase (DNA) I 0.0241832
GOLGA4 golgin A4 0.0238523
WSB1 WD repeat and SOCS box containing 1 0.0238017
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0234997
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0234331
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0233335
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0232271
LIFR leukemia inhibitory factor receptor alpha 0.0230622
SLC38A2 solute carrier family 38, member 2 0.0230313
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0229152
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0227764
RB1CC1 RB1-inducible coiled-coil 1 0.0227059
SRPK2 SRSF protein kinase 2 0.0226841
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0226557
ATOSA atos homolog A 0.0225433
CTBP2 C-terminal binding protein 2 0.0225395
MYO1B myosin IB 0.0222687
LCORL ligand dependent nuclear receptor corepressor-like 0.0222239
YBX3 Y box binding protein 3 0.0221758
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0221402
UBA6 ubiquitin-like modifier activating enzyme 6 0.0220816

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.298723
NRG1 neuregulin 1 -0.257083
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.246633
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.177615
HMGA2 high mobility group AT-hook 2 -0.125921
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109985
SQSTM1 sequestosome 1 -0.104458
TMSB10 thymosin beta 10 -0.0966439
ITGA1 integrin, alpha 1 -0.0950153
GLIS3 GLIS family zinc finger 3 -0.0912804
ASPH aspartate beta-hydroxylase -0.071541
HLA-B major histocompatibility complex, class I, B -0.0701379
VCL vinculin -0.0658552
S100A6 S100 calcium binding protein A6 -0.0634521
IFI27 interferon, alpha-inducible protein 27 -0.0615158
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0614125
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0609149
TMSB4X thymosin beta 4, X-linked -0.0598318
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0563937
RAI14 retinoic acid induced 14 -0.0521146
LOC102724023 ES1 protein homolog, mitochondrial -0.0504683
TPT1 tumor protein, translationally-controlled 1 -0.0493813
SOX4 SRY (sex determining region Y)-box 4 -0.048889
FTL ferritin, light polypeptide -0.0481438
DNAH5 dynein, axonemal, heavy chain 5 -0.0466431
PTMA prothymosin, alpha -0.0465774
ETV6 ets variant 6 -0.0415638
NDRG1 N-myc downstream regulated 1 -0.0392335
ACTG1 actin gamma 1 -0.0391638
EGR1 early growth response 1 -0.039053
VIM vimentin -0.0389727
LRRC23 leucine rich repeat containing 23 -0.036935
ENO2 enolase 2 (gamma, neuronal) -0.0368132
IFI6 interferon, alpha-inducible protein 6 -0.0362486
ENO1 enolase 1, (alpha) -0.0358704
SYT1 synaptotagmin I -0.0357821
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0357789
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0357621
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0355998
MBD5 methyl-CpG binding domain protein 5 -0.0355699
NCOA7 nuclear receptor coactivator 7 -0.0355389
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0346943
MRPS6 mitochondrial ribosomal protein S6 -0.0346706
SFRP1 secreted frizzled-related protein 1 -0.0336865
SLC35F3 solute carrier family 35, member F3 -0.0328231
ZBTB20 zinc finger and BTB domain containing 20 -0.0323822
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0304771
IGFBP3 insulin-like growth factor binding protein 3 -0.030385
PLIN2 perilipin 2 -0.0303581
TENM4 teneurin transmembrane protein 4 -0.0299759
TAS2R14 taste receptor, type 2, member 14 -0.0297271
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0286635
AHRR aryl-hydrocarbon receptor repressor -0.0286277
CENPF centromere protein F, 350/400kDa -0.0277938
AEBP2 AE binding protein 2 -0.0277922
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0276546
STC2 stanniocalcin 2 -0.0276474
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0269018
PTPRD protein tyrosine phosphatase, receptor type, D -0.0263393
TGFA transforming growth factor, alpha -0.0261321
TFPI2 tissue factor pathway inhibitor 2 -0.0260781
HMGA1 high mobility group AT-hook 1 -0.0254882
NT5E 5'-nucleotidase, ecto (CD73) -0.0247588
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0244782
FAM20C family with sequence similarity 20, member C -0.0238776
B2M beta-2-microglobulin -0.0235172
S100A10 S100 calcium binding protein A10 -0.0234303
NAV1 neuron navigator 1 -0.0232696
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0232204
LOX lysyl oxidase -0.0230568
HLA-A major histocompatibility complex, class I, A -0.0230379
S100A9 S100 calcium binding protein A9 -0.022908
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0228194
CD63 CD63 molecule -0.0228147
CANX calnexin -0.0226892
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0224781
TSC22D1 TSC22 domain family, member 1 -0.0224588
LMNA lamin A/C -0.0224043
MAML2 mastermind-like 2 (Drosophila) -0.0219245
TNNC1 troponin C type 1 (slow) -0.0216672
LOC112694756 uncharaterized LOC112694756 -0.021606
SOX5 SRY (sex determining region Y)-box 5 -0.0215029
RPL31 ribosomal protein L31 -0.0214907
TBC1D22A TBC1 domain family, member 22A -0.0213964
SPDYA speedy/RINGO cell cycle regulator family member A -0.021096
DUSP6 dual specificity phosphatase 6 -0.020624
TTC28 tetratricopeptide repeat domain 28 -0.0205542
RNF213 ring finger protein 213 -0.0201594
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0201194
IER3 immediate early response 3 -0.020073
JUN jun proto-oncogene -0.019932
CCDC91 coiled-coil domain containing 91 -0.0198783
DPYD dihydropyrimidine dehydrogenase -0.019852
OSMR oncostatin M receptor -0.0197224
TNS3 tensin 3 -0.0196298
OXR1 oxidation resistance 1 -0.0195794
AHNAK2 AHNAK nucleoprotein 2 -0.019434
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0193515
CTSD cathepsin D -0.0192283
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0191056