| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/44599207 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Siponimod relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | 5.27 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 1.16 |
| PRELID3B | PRELI domain containing 3B | 1.11 |
| CCDC150 | coiled-coil domain containing 150 | 1.11 |
| TMC4 | transmembrane channel-like 4 | 0.85 |
| CFAP57 | cilia and flagella associated protein 57 | 0.69 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.69 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.64 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.62 |
| DIPK1B | divergent protein kinase domain 1B | 0.61 |
| PLIN2 | perilipin 2 | 0.6 |
| PKM | pyruvate kinase, muscle | 0.58 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.56 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.56 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.5 |
| DDTL | D-dopachrome tautomerase-like | 0.49 |
| LONP2 | lon peptidase 2, peroxisomal | 0.48 |
| ACTBL2 | actin, beta-like 2 | 0.48 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.46 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.44 |
| KIAA1210 | KIAA1210 | 0.43 |
| ZNF414 | zinc finger protein 414 | 0.39 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.38 |
| ACOX1 | acyl-CoA oxidase 1, palmitoyl | 0.38 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.36 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.36 |
| TOB2 | transducer of ERBB2, 2 | 0.36 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.36 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.34 |
| PLAUR | plasminogen activator, urokinase receptor | 0.34 |
| RGN | regucalcin | 0.34 |
| KLHL15 | kelch-like family member 15 | 0.33 |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 | 0.33 |
| ZBTB7B | zinc finger and BTB domain containing 7B | 0.33 |
| PLD6 | phospholipase D family, member 6 | 0.33 |
| ZNF777 | zinc finger protein 777 | 0.32 |
| NEMP2 | nuclear envelope integral membrane protein 2 | 0.32 |
| TUFT1 | tuftelin 1 | 0.32 |
| HSPA14 | heat shock 70kDa protein 14 | 0.31 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | 0.31 |
| CENPH | centromere protein H | 0.3 |
| KANK3 | KN motif and ankyrin repeat domains 3 | 0.3 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.3 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | 0.3 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.3 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.3 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.3 |
| CEP70 | centrosomal protein 70kDa | 0.3 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.29 |
| RHOT2 | ras homolog family member T2 | 0.29 |
| SNX5 | sorting nexin 5 | 0.29 |
| STK17B | serine/threonine kinase 17b | 0.29 |
| DOCK3 | dedicator of cytokinesis 3 | 0.29 |
| RPL37A | ribosomal protein L37a | 0.29 |
| ABHD3 | abhydrolase domain containing 3 | 0.29 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.29 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | 0.28 |
| EED | embryonic ectoderm development | 0.28 |
| SFXN4 | sideroflexin 4 | 0.28 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.28 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.28 |
| ADCY9 | adenylate cyclase 9 | 0.28 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.28 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.28 |
| TRMT61A | tRNA methyltransferase 61A | 0.28 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 0.28 |
| TP73 | tumor protein p73 | 0.28 |
| VIM | vimentin | 0.28 |
| ABHD15 | abhydrolase domain containing 15 | 0.27 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | 0.27 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | 0.27 |
| NAF1 | nuclear assembly factor 1 ribonucleoprotein | 0.27 |
| MFSD14B | major facilitator superfamily domain containing 14B | 0.27 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.27 |
| ZNF136 | zinc finger protein 136 | 0.27 |
| FEM1A | fem-1 homolog a (C. elegans) | 0.27 |
| TJP1 | tight junction protein 1 | 0.27 |
| SKIL | SKI-like proto-oncogene | 0.26 |
| SQLE | squalene epoxidase | 0.26 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | 0.26 |
| DES | desmin | 0.26 |
| BORA | bora, aurora kinase A activator | 0.26 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.26 |
| FAM210B | family with sequence similarity 210, member B | 0.26 |
| AKTIP | AKT interacting protein | 0.26 |
| PCYT1B | phosphate cytidylyltransferase 1, choline, beta | 0.25 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 0.25 |
| PPHLN1 | periphilin 1 | 0.25 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.25 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | 0.25 |
| SURF2 | surfeit 2 | 0.25 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.25 |
| ZNF714 | zinc finger protein 714 | 0.25 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.25 |
| AEBP2 | AE binding protein 2 | 0.24 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.24 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.24 |
| PIR | pirin (iron-binding nuclear protein) | 0.24 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.24 |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | -1.33 |
| SBSN | suprabasin | -1.19 |
| FBN3 | fibrillin 3 | -0.89 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | -0.82 |
| WWC3 | WWC family member 3 | -0.73 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.64 |
| SH2B3 | SH2B adaptor protein 3 | -0.64 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.62 |
| GON7 | GON7 subunit of KEOPS complex | -0.62 |
| HSBP1 | heat shock factor binding protein 1 | -0.6 |
| ADIRF | adipogenesis regulatory factor | -0.57 |
| MIEN1 | migration and invasion enhancer 1 | -0.54 |
| BANF1 | barrier to autointegration factor 1 | -0.51 |
| SMIM26 | small integral membrane protein 26 | -0.49 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.49 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.48 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.47 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.46 |
| IFT43 | intraflagellar transport 43 | -0.46 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.45 |
| TMSB10 | thymosin beta 10 | -0.44 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.43 |
| IGF1R | insulin-like growth factor 1 receptor | -0.43 |
| S100A6 | S100 calcium binding protein A6 | -0.42 |
| PAH | phenylalanine hydroxylase | -0.42 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.42 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.41 |
| BAG4 | BCL2-associated athanogene 4 | -0.41 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | -0.4 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.4 |
| BMP4 | bone morphogenetic protein 4 | -0.4 |
| MT1X | metallothionein 1X | -0.39 |
| TMEM135 | transmembrane protein 135 | -0.39 |
| MED10 | mediator complex subunit 10 | -0.39 |
| CBR3 | carbonyl reductase 3 | -0.39 |
| HBA1 | hemoglobin, alpha 1 | -0.38 |
| APOB | apolipoprotein B | -0.38 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.38 |
| TLE5 | TLE family member 5, transcriptional modulator | -0.37 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.37 |
| ATP9A | ATPase, class II, type 9A | -0.37 |
| S100A14 | S100 calcium binding protein A14 | -0.37 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -0.37 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.36 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.36 |
| ERH | enhancer of rudimentary homolog (Drosophila) | -0.36 |
| PSAP | prosaposin | -0.36 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | -0.36 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.35 |
| AMPD1 | adenosine monophosphate deaminase 1 | -0.35 |
| NFYB | nuclear transcription factor Y, beta | -0.35 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.35 |
| DAP | death-associated protein | -0.35 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.34 |
| ETV5 | ets variant 5 | -0.34 |
| PTK6 | protein tyrosine kinase 6 | -0.33 |
| NRBF2 | nuclear receptor binding factor 2 | -0.33 |
| ZNF524 | zinc finger protein 524 | -0.33 |
| MBP | myelin basic protein | -0.33 |
| MT1E | metallothionein 1E | -0.33 |
| C17ORF53 | chromosome 17 open reading frame 53 | -0.33 |
| ABRACL | ABRA C-terminal like | -0.33 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.33 |
| TRIM29 | tripartite motif containing 29 | -0.33 |
| PFDN1 | prefoldin subunit 1 | -0.32 |
| CLTA | clathrin, light chain A | -0.32 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.32 |
| TRIM35 | tripartite motif containing 35 | -0.31 |
| GSTZ1 | glutathione S-transferase zeta 1 | -0.31 |
| S100A11 | S100 calcium binding protein A11 | -0.31 |
| FAM219B | family with sequence similarity 219, member B | -0.31 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.3 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.3 |
| MT1F | metallothionein 1F | -0.29 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.29 |
| KDM8 | lysine (K)-specific demethylase 8 | -0.29 |
| ZNF724 | zinc finger protein 724 | -0.29 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | -0.28 |
| MTPN | myotrophin | -0.28 |
| SARDH | sarcosine dehydrogenase | -0.28 |
| SPTB | spectrin, beta, erythrocytic | -0.27 |
| ABHD13 | abhydrolase domain containing 13 | -0.27 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.27 |
| MCOLN3 | mucolipin 3 | -0.27 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.27 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | -0.27 |
| BLOC1S1 | biogenesis of lysosomal organelles complex-1, subunit 1 | -0.27 |
| MXRA7 | matrix-remodelling associated 7 | -0.26 |
| ALDOC | aldolase C, fructose-bisphosphate | -0.26 |
| DUSP5 | dual specificity phosphatase 5 | -0.26 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.26 |
| DLG2 | discs, large homolog 2 (Drosophila) | -0.26 |
| RNASEL | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | -0.26 |
| GID8 | GID complex subunit 8 | -0.26 |
| NUTF2 | nuclear transport factor 2 | -0.25 |
| LIPT1 | lipoyltransferase 1 | -0.25 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.25 |
| ANGPTL4 | angiopoietin-like 4 | -0.25 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.25 |
| OSBPL2 | oxysterol binding protein-like 2 | -0.25 |
