| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.136659 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.122956 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0979506 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0927796 |
| FBN1 | fibrillin 1 | 0.0903701 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0780363 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0760173 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0746428 |
| PLAT | plasminogen activator, tissue | 0.0516452 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0486523 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0486517 |
| FLNB | filamin B, beta | 0.0463081 |
| AUTS2 | autism susceptibility candidate 2 | 0.0462839 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0439473 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0414289 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0397814 |
| LOXL2 | lysyl oxidase-like 2 | 0.0396389 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.039163 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0386371 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0371801 |
| SBF2 | SET binding factor 2 | 0.0367987 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0351438 |
| RTN4 | reticulon 4 | 0.0349633 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0332589 |
| ATP13A3 | ATPase type 13A3 | 0.0328837 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0327972 |
| SEPTIN9 | septin 9 | 0.0327828 |
| UBC | ubiquitin C | 0.0319057 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0297624 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.029346 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0291592 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0289605 |
| C1D | C1D nuclear receptor corepressor | 0.0288115 |
| COPA | coatomer protein complex, subunit alpha | 0.0284561 |
| OGA | O-GlcNAcase | 0.0284277 |
| NAV2 | neuron navigator 2 | 0.0281235 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0278076 |
| CD99 | CD99 molecule | 0.0277812 |
| ATXN1 | ataxin 1 | 0.0273978 |
| NAV1 | neuron navigator 1 | 0.027013 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0267817 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0261708 |
| ZNF148 | zinc finger protein 148 | 0.0261286 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0260223 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0259465 |
| FNIP1 | folliculin interacting protein 1 | 0.0258106 |
| COL1A2 | collagen, type I, alpha 2 | 0.0257068 |
| CD44 | CD44 molecule (Indian blood group) | 0.0248968 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0240398 |
| YEATS2 | YEATS domain containing 2 | 0.0233055 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0232139 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.022773 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0227436 |
| GLIS3 | GLIS family zinc finger 3 | 0.0227355 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0225379 |
| CD109 | CD109 molecule | 0.0220899 |
| MAP4 | microtubule-associated protein 4 | 0.0215739 |
| NF1 | neurofibromin 1 | 0.0213879 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0211483 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0211294 |
| USP34 | ubiquitin specific peptidase 34 | 0.021112 |
| NOTCH2 | notch 2 | 0.0209621 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0209441 |
| SP3 | Sp3 transcription factor | 0.020925 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0207403 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.020693 |
| CDK19 | cyclin-dependent kinase 19 | 0.0206872 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0203956 |
| ZNF292 | zinc finger protein 292 | 0.0203208 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0203077 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0201515 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0200776 |
| OPTN | optineurin | 0.0199073 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0197092 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0194608 |
| GPC6 | glypican 6 | 0.0194172 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0192978 |
| MB21D2 | Mab-21 domain containing 2 | 0.0192699 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0192343 |
| EPAS1 | endothelial PAS domain protein 1 | 0.01905 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.018663 |
| PTK2 | protein tyrosine kinase 2 | 0.0186058 |
| ATL3 | atlastin GTPase 3 | 0.0185759 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0185669 |
| CLIC4 | chloride intracellular channel 4 | 0.0184919 |
| MYADM | myeloid-associated differentiation marker | 0.0184762 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.018426 |
| COG5 | component of oligomeric golgi complex 5 | 0.018369 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0182798 |
| KIFAP3 | kinesin-associated protein 3 | 0.0182567 |
| STC1 | stanniocalcin 1 | 0.0181882 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0181774 |
| TMOD1 | tropomodulin 1 | 0.0181654 |
| LRRC49 | leucine rich repeat containing 49 | 0.0180887 |
| UBAP1 | ubiquitin associated protein 1 | 0.0179422 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0178601 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.0177071 |
| INSIG2 | insulin induced gene 2 | 0.0176211 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0176121 |
| EXOC6B | exocyst complex component 6B | 0.0174516 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.240485 |
| TMSB10 | thymosin beta 10 | -0.227501 |
| MT2A | metallothionein 2A | -0.104809 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0880004 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0824647 |
| CSTB | cystatin B (stefin B) | -0.0741157 |
| LMNA | lamin A/C | -0.0722394 |
| MAP1B | microtubule-associated protein 1B | -0.0720698 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0712127 |
| B2M | beta-2-microglobulin | -0.0707289 |
| FN1 | fibronectin 1 | -0.0693012 |
| CDH13 | cadherin 13 | -0.0660134 |
| RIGI | RNA sensor RIG-I | -0.0607517 |
| PTMA | prothymosin, alpha | -0.060526 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0561735 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.055196 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0504302 |
| COL5A1 | collagen, type V, alpha 1 | -0.0500909 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0474363 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0443162 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0435774 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0427233 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0423701 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0419434 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0411119 |
| HLA-B | major histocompatibility complex, class I, B | -0.0407425 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0402897 |
| AHNAK | AHNAK nucleoprotein | -0.0400972 |
| FSTL1 | follistatin-like 1 | -0.0385122 |
| TMSB4X | thymosin beta 4, X-linked | -0.036908 |
| RPL37A | ribosomal protein L37a | -0.0367986 |
| S100A10 | S100 calcium binding protein A10 | -0.036202 |
| TPM4 | tropomyosin 4 | -0.0359597 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0354558 |
| FTL | ferritin, light polypeptide | -0.0346098 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0344178 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.034359 |
| RPS3 | ribosomal protein S3 | -0.0336403 |
| SP100 | SP100 nuclear antigen | -0.0331737 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0320478 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0320084 |
| TAGLN2 | transgelin 2 | -0.0318336 |
| SQSTM1 | sequestosome 1 | -0.0316065 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0306471 |
| S100A6 | S100 calcium binding protein A6 | -0.0305425 |
| IL7R | interleukin 7 receptor | -0.0303863 |
| RPS19 | ribosomal protein S19 | -0.0303052 |
| PRSS23 | protease, serine, 23 | -0.0298527 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0290834 |
| RPS6 | ribosomal protein S6 | -0.0290127 |
| PODXL | podocalyxin-like | -0.0289962 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0289523 |
| CALR | calreticulin | -0.0288968 |
| RPLP1 | ribosomal protein, large, P1 | -0.0277792 |
| RPL19 | ribosomal protein L19 | -0.0274963 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0274351 |
| RPL23 | ribosomal protein L23 | -0.0274227 |
| RPL26 | ribosomal protein L26 | -0.027399 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0272032 |
| RRBP1 | ribosome binding protein 1 | -0.0271327 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0270788 |
| RPLP2 | ribosomal protein, large, P2 | -0.0269656 |
| RPL12 | ribosomal protein L12 | -0.0263972 |
| RPL35A | ribosomal protein L35a | -0.0256385 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0255314 |
| S100A11 | S100 calcium binding protein A11 | -0.0251613 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0249028 |
| RPS8 | ribosomal protein S8 | -0.0248416 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0244705 |
| RACK1 | receptor for activated C kinase 1 | -0.0244379 |
| SEC61G | Sec61 gamma subunit | -0.0242812 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0242027 |
| LRRC17 | leucine rich repeat containing 17 | -0.0240627 |
| RPS14 | ribosomal protein S14 | -0.0236572 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.023033 |
| CCND1 | cyclin D1 | -0.0227046 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0226792 |
| RPS24 | ribosomal protein S24 | -0.0225739 |
| MX2 | MX dynamin-like GTPase 2 | -0.0225322 |
| ASPH | aspartate beta-hydroxylase | -0.0219125 |
| S100A4 | S100 calcium binding protein A4 | -0.0217852 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0213406 |
| PLXNA2 | plexin A2 | -0.021216 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0211741 |
| RPL35 | ribosomal protein L35 | -0.0209045 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0207548 |
| EFNA5 | ephrin-A5 | -0.0206472 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0205872 |
| RPL28 | ribosomal protein L28 | -0.0205826 |
| RPS12 | ribosomal protein S12 | -0.0205819 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0205107 |
| POTEF | POTE ankyrin domain family, member F | -0.0203656 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0203382 |
| RPL36 | ribosomal protein L36 | -0.0201901 |
| SEPTIN7 | septin 7 | -0.0198963 |
| PCDH7 | protocadherin 7 | -0.0198543 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0198302 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0196963 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0195593 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0194511 |
