| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0830495 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0806422 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0688606 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0647957 |
| PCBP2 | poly(rC) binding protein 2 | 0.0621184 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0547599 |
| MED13L | mediator complex subunit 13-like | 0.0523552 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.049813 |
| DST | dystonin | 0.044185 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0404974 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.040381 |
| AHNAK | AHNAK nucleoprotein | 0.0402467 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.04004 |
| NEK7 | NIMA-related kinase 7 | 0.0372059 |
| EPHA6 | EPH receptor A6 | 0.0366927 |
| TENM3 | teneurin transmembrane protein 3 | 0.0359447 |
| PLK2 | polo-like kinase 2 | 0.0359317 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0352382 |
| TXNRD1 | thioredoxin reductase 1 | 0.03521 |
| MMP12 | matrix metallopeptidase 12 | 0.034904 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0345329 |
| DSCAM | Down syndrome cell adhesion molecule | 0.033361 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0331144 |
| ECT2 | epithelial cell transforming 2 | 0.032496 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0321946 |
| OXR1 | oxidation resistance 1 | 0.0317662 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0312508 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0309448 |
| AXIN2 | axin 2 | 0.0305091 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0303505 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0303147 |
| CPOX | coproporphyrinogen oxidase | 0.0303053 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0302726 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.029936 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0297697 |
| MPG | N-methylpurine-DNA glycosylase | 0.0296718 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0294099 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0292791 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0291714 |
| CCNL1 | cyclin L1 | 0.0289547 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0286887 |
| LMO7 | LIM domain 7 | 0.0286488 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0285885 |
| CDK6 | cyclin-dependent kinase 6 | 0.0284898 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0276618 |
| RAD51B | RAD51 paralog B | 0.0273469 |
| EXOC6B | exocyst complex component 6B | 0.0272991 |
| ANXA1 | annexin A1 | 0.0271545 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0267011 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0265266 |
| IL6ST | interleukin 6 signal transducer | 0.0263472 |
| ATP11A | ATPase, class VI, type 11A | 0.0258842 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0256854 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0255185 |
| ZNF292 | zinc finger protein 292 | 0.0254942 |
| USP34 | ubiquitin specific peptidase 34 | 0.0253248 |
| PGK1 | phosphoglycerate kinase 1 | 0.0251438 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0249885 |
| SMYD3 | SET and MYND domain containing 3 | 0.0248401 |
| HDAC9 | histone deacetylase 9 | 0.0248204 |
| LDHA | lactate dehydrogenase A | 0.0248158 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0247654 |
| CDK19 | cyclin-dependent kinase 19 | 0.024677 |
| RBM39 | RNA binding motif protein 39 | 0.0236734 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0235364 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0234852 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0230059 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0228228 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0227572 |
| HDLBP | high density lipoprotein binding protein | 0.0226542 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0222135 |
| SEPTIN2 | septin 2 | 0.0219688 |
| PHF21A | PHD finger protein 21A | 0.0219672 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0219068 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0217334 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0215034 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0212047 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0209691 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0209011 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0207282 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0204901 |
| PCNP | PEST proteolytic signal containing nuclear protein | 0.0204177 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0202951 |
| XPO1 | exportin 1 | 0.0202903 |
| NF1 | neurofibromin 1 | 0.0201348 |
| OGA | O-GlcNAcase | 0.0200578 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0198203 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0197403 |
| USP15 | ubiquitin specific peptidase 15 | 0.0196043 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0195584 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.019518 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0195156 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 0.0193984 |
| AFDN | afadin, adherens junction formation factor | 0.0193366 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0192644 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0191637 |
| RHBDD1 | rhomboid domain containing 1 | 0.0191327 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0190689 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0190351 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0189497 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.302053 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.149411 |
| ACTG1 | actin gamma 1 | -0.0960058 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.083674 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0758505 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0622746 |
| AREG | amphiregulin | -0.0619299 |
| PTMA | prothymosin, alpha | -0.060804 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.060176 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0584217 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0571361 |
| HMGA2 | high mobility group AT-hook 2 | -0.0555998 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0528481 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0509794 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0439732 |
| ASPH | aspartate beta-hydroxylase | -0.0431081 |
| TMEM41B | transmembrane protein 41B | -0.0401873 |
| RPS6 | ribosomal protein S6 | -0.040058 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0400381 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0390571 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0389465 |
| RPS27A | ribosomal protein S27a | -0.0382017 |
| RPS8 | ribosomal protein S8 | -0.0368876 |
| RPL35A | ribosomal protein L35a | -0.0363613 |
| RPLP1 | ribosomal protein, large, P1 | -0.0346842 |
| NHSL1 | NHS-like 1 | -0.0341996 |
| JMJD1C | jumonji domain containing 1C | -0.0338417 |
| MTAP | methylthioadenosine phosphorylase | -0.0338012 |
| PCDH7 | protocadherin 7 | -0.0326521 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0325205 |
| S100A6 | S100 calcium binding protein A6 | -0.0318937 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0309099 |
| TMSB10 | thymosin beta 10 | -0.0306406 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0295417 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0279955 |
| NAV3 | neuron navigator 3 | -0.0279181 |
| RPS29 | ribosomal protein S29 | -0.0277056 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0266398 |
| RPL37 | ribosomal protein L37 | -0.0263882 |
| S100A10 | S100 calcium binding protein A10 | -0.0260378 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.026029 |
| PRDX1 | peroxiredoxin 1 | -0.0259612 |
| RPL34 | ribosomal protein L34 | -0.0259521 |
| CUX1 | cut-like homeobox 1 | -0.0254084 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0253691 |
| HMGA1 | high mobility group AT-hook 1 | -0.025095 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0250448 |
| PCDH9 | protocadherin 9 | -0.0242318 |
| RPS12 | ribosomal protein S12 | -0.0240844 |
| RPL9 | ribosomal protein L9 | -0.0238304 |
| RPL37A | ribosomal protein L37a | -0.0237436 |
| RTN4 | reticulon 4 | -0.023665 |
| MKI67 | marker of proliferation Ki-67 | -0.0234595 |
| RPLP2 | ribosomal protein, large, P2 | -0.0229201 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.022748 |
| BRI3BP | BRI3 binding protein | -0.0227392 |
| RPL26 | ribosomal protein L26 | -0.0227104 |
| RPS21 | ribosomal protein S21 | -0.0226823 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0225852 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0224355 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0213003 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.021168 |
| GNAS | GNAS complex locus | -0.0207805 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0192596 |
| RPS13 | ribosomal protein S13 | -0.0188603 |
| RPL38 | ribosomal protein L38 | -0.018776 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0186308 |
| ZNF804A | zinc finger protein 804A | -0.0186115 |
| RPS11 | ribosomal protein S11 | -0.0184453 |
| TPM4 | tropomyosin 4 | -0.0182402 |
| RPS27 | ribosomal protein S27 | -0.0180996 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0176595 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0175972 |
| EGR1 | early growth response 1 | -0.017592 |
| RASAL2 | RAS protein activator like 2 | -0.0175557 |
| TBCA | tubulin folding cofactor A | -0.0175397 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0170586 |
| EHBP1 | EH domain binding protein 1 | -0.0169265 |
| RPLP0 | ribosomal protein, large, P0 | -0.0165859 |
| SET | SET nuclear proto-oncogene | -0.0163564 |
| HMGB1 | high mobility group box 1 | -0.0163216 |
| KIF18B | kinesin family member 18B | -0.0162918 |
| TUBA1B | tubulin, alpha 1b | -0.0162783 |
| RPS23 | ribosomal protein S23 | -0.0161487 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.016114 |
| RPL36A | ribosomal protein L36a | -0.0160533 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -0.0160254 |
| RSU1 | Ras suppressor protein 1 | -0.0160245 |
| ADIPOR2 | adiponectin receptor 2 | -0.0156887 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0156388 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0156222 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0153749 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.0152333 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0150157 |
| HDGF | hepatoma-derived growth factor | -0.0148906 |
| RRM2 | ribonucleotide reductase M2 | -0.0147776 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0146042 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | -0.0144209 |
| ANK2 | ankyrin 2, neuronal | -0.0142701 |
| CAVIN1 | caveolae associated protein 1 | -0.0141421 |
