Sivelestat (sodium tetrahydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.181669
ZCCHC7 zinc finger, CCHC domain containing 7 0.117471
GPC6 glypican 6 0.0899327
IGFBP3 insulin-like growth factor binding protein 3 0.0886033
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0870217
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0733181
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0717398
BIRC6 baculoviral IAP repeat containing 6 0.0656337
NDRG1 N-myc downstream regulated 1 0.0635031
SOD2 superoxide dismutase 2, mitochondrial 0.0619875
TRIO trio Rho guanine nucleotide exchange factor 0.0548426
UBA6 ubiquitin-like modifier activating enzyme 6 0.0546272
FNDC3B fibronectin type III domain containing 3B 0.0521568
PLK2 polo-like kinase 2 0.0515297
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0501462
AKAP9 A kinase (PRKA) anchor protein 9 0.04974
SPAG9 sperm associated antigen 9 0.0496754
ATP13A3 ATPase type 13A3 0.0487544
COG5 component of oligomeric golgi complex 5 0.0483107
KMT2C lysine (K)-specific methyltransferase 2C 0.0475182
SND1 staphylococcal nuclease and tudor domain containing 1 0.0464138
TTC3 tetratricopeptide repeat domain 3 0.0462452
CMIP c-Maf inducing protein 0.0459357
DLG1 discs, large homolog 1 (Drosophila) 0.0458265
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0456104
MSN moesin 0.0444953
SCFD2 sec1 family domain containing 2 0.043779
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0433581
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0414633
ZFP36L1 ZFP36 ring finger protein-like 1 0.0412998
ADAM9 ADAM metallopeptidase domain 9 0.041057
COPA coatomer protein complex, subunit alpha 0.0404218
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0383502
PTBP3 polypyrimidine tract binding protein 3 0.0381731
ADAM10 ADAM metallopeptidase domain 10 0.0379038
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0376883
PAX8 paired box 8 0.0373896
ESYT2 extended synaptotagmin-like protein 2 0.0362692
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0362249
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0359561
PDIA3 protein disulfide isomerase family A, member 3 0.0349547
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.034777
PDIA6 protein disulfide isomerase family A, member 6 0.0347712
ITGAV integrin, alpha V 0.0344131
COG6 component of oligomeric golgi complex 6 0.0343936
TRAM1 translocation associated membrane protein 1 0.0334517
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0324871
GIGYF2 GRB10 interacting GYF protein 2 0.0323653
SRPK2 SRSF protein kinase 2 0.0322987
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0320454
ATXN2 ataxin 2 0.0319466
PRKCA protein kinase C, alpha 0.0318745
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0318531
NAV2 neuron navigator 2 0.0318062
SEC31A SEC31 homolog A (S. cerevisiae) 0.0315893
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0311922
MBNL2 muscleblind-like splicing regulator 2 0.0310816
USP34 ubiquitin specific peptidase 34 0.0309772
PTK2 protein tyrosine kinase 2 0.0309631
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0308905
FNIP1 folliculin interacting protein 1 0.0306931
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0303723
TPM3 tropomyosin 3 0.0302683
VMP1 vacuole membrane protein 1 0.0301648
UBE2H ubiquitin-conjugating enzyme E2H 0.0298709
ACBD3 acyl-CoA binding domain containing 3 0.0296817
SBF2 SET binding factor 2 0.0294392
SPDYA speedy/RINGO cell cycle regulator family member A 0.0294143
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0292729
ADAM17 ADAM metallopeptidase domain 17 0.0291314
PLIN2 perilipin 2 0.0290878
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0290508
PCBP2 poly(rC) binding protein 2 0.0280745
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0280299
MAP1B microtubule-associated protein 1B 0.0275341
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0274452
CADPS2 Ca++-dependent secretion activator 2 0.0274034
STOM stomatin 0.0273779
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0273504
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0273446
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0271823
IQGAP1 IQ motif containing GTPase activating protein 1 0.0269044
CALR calreticulin 0.0268754
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0268015
RNF220 ring finger protein 220 0.0266709
LPP LIM domain containing preferred translocation partner in lipoma 0.0266361
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0266115
ZBTB20 zinc finger and BTB domain containing 20 0.0265619
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0265051
SUCO SUN domain containing ossification factor 0.0263824
CDK13 cyclin-dependent kinase 13 0.0260596
MYADM myeloid-associated differentiation marker 0.0260074
KDM4C lysine (K)-specific demethylase 4C 0.0259969
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0259808
UBAP2 ubiquitin associated protein 2 0.0258538
CLTC clathrin, heavy chain (Hc) 0.0257041
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0257026
CSNK1A1 casein kinase 1, alpha 1 0.0256627
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0256299
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0256205

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.136743
FTL ferritin, light polypeptide -0.120405
CXCL8 chemokine (C-X-C motif) ligand 8 -0.117932
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102901
VIM vimentin -0.0901243
NAMPT nicotinamide phosphoribosyltransferase -0.0892698
TPT1 tumor protein, translationally-controlled 1 -0.078724
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.072326
MT2A metallothionein 2A -0.0710654
RPL26 ribosomal protein L26 -0.0599588
RPLP1 ribosomal protein, large, P1 -0.0599437
RPL35A ribosomal protein L35a -0.0583856
ASPH aspartate beta-hydroxylase -0.0559058
RPS6 ribosomal protein S6 -0.0550013
RPLP2 ribosomal protein, large, P2 -0.0549758
CCL2 chemokine (C-C motif) ligand 2 -0.0535496
RPS8 ribosomal protein S8 -0.0535372
RPL23 ribosomal protein L23 -0.0513406
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0507436
RPS4X ribosomal protein S4, X-linked -0.0501466
RPS19 ribosomal protein S19 -0.0471273
RPS24 ribosomal protein S24 -0.0438569
RPL19 ribosomal protein L19 -0.0437686
RPL34 ribosomal protein L34 -0.0436808
RPL12 ribosomal protein L12 -0.0416376
NAP1L1 nucleosome assembly protein 1-like 1 -0.0413761
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.040155
HMGB1 high mobility group box 1 -0.0396939
G0S2 G0/G1 switch 2 -0.0388995
CD44 CD44 molecule (Indian blood group) -0.0386718
HLA-B major histocompatibility complex, class I, B -0.0385907
RPS27A ribosomal protein S27a -0.0385761
RPL30 ribosomal protein L30 -0.0385553
HSPB1 heat shock 27kDa protein 1 -0.0384699
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0372829
RPL37A ribosomal protein L37a -0.0369535
RPL35 ribosomal protein L35 -0.036907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0366574
RPL9 ribosomal protein L9 -0.0361663
PTMA prothymosin, alpha -0.0359113
RPS20 ribosomal protein S20 -0.03526
EIF1 eukaryotic translation initiation factor 1 -0.0328847
RPL28 ribosomal protein L28 -0.0327261
RPL7 ribosomal protein L7 -0.0325976
RACK1 receptor for activated C kinase 1 -0.0324848
RRBP1 ribosome binding protein 1 -0.0318002
B2M beta-2-microglobulin -0.0310552
RAD21 RAD21 homolog (S. pombe) -0.0301145
RPS12 ribosomal protein S12 -0.0292319
RPL37 ribosomal protein L37 -0.0285909
RPLP0 ribosomal protein, large, P0 -0.0281106
RPS2 ribosomal protein S2 -0.0278441
COTL1 coactosin-like F-actin binding protein 1 -0.0278225
RPL31 ribosomal protein L31 -0.0277667
ANXA2 annexin A2 -0.0271347
RPL11 ribosomal protein L11 -0.0268835
RPL36 ribosomal protein L36 -0.0268584
S100A10 S100 calcium binding protein A10 -0.0266257
RPS17 ribosomal protein S17 -0.026126
OSMR oncostatin M receptor -0.0259667
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0256421
S100A9 S100 calcium binding protein A9 -0.0239725
VCL vinculin -0.0239168
RPS21 ribosomal protein S21 -0.0236685
RPL38 ribosomal protein L38 -0.0236066
DDIT4 DNA-damage-inducible transcript 4 -0.0234784
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.02324
RPL36A ribosomal protein L36a -0.0231453
ACTG1 actin gamma 1 -0.0228034
RPS5 ribosomal protein S5 -0.0226054
PRDX1 peroxiredoxin 1 -0.022523
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0220538
RPS3 ribosomal protein S3 -0.0220212
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0220073
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0218781
GNAS GNAS complex locus -0.021855
RPL7A ribosomal protein L7a -0.0217245
RPS16 ribosomal protein S16 -0.021638
RPS27 ribosomal protein S27 -0.0211465
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0210621
CAVIN1 caveolae associated protein 1 -0.0209136
SEC61G Sec61 gamma subunit -0.0209101
NDUFA4 NDUFA4, mitochondrial complex associated -0.0206398
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.020431
RPS14 ribosomal protein S14 -0.0204118
HMGB2 high mobility group box 2 -0.020348
RPL27 ribosomal protein L27 -0.0203051
ARF1 ADP-ribosylation factor 1 -0.0202203
KLF6 Kruppel-like factor 6 -0.0199621
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0197855
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0195964
RPL32 ribosomal protein L32 -0.0194236
HLA-C major histocompatibility complex, class I, C -0.0194097
STK17A serine/threonine kinase 17a -0.0193607
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0191865
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0191311
RPL18 ribosomal protein L18 -0.0190811
IFI16 interferon, gamma-inducible protein 16 -0.0188161
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0185102
CP ceruloplasmin (ferroxidase) -0.0184063