Sivelestat (sodium tetrahydrate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.128637
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.104732
FNDC3B fibronectin type III domain containing 3B 0.101631
FTH1 ferritin, heavy polypeptide 1 0.0952531
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0939049
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0905921
SPAG9 sperm associated antigen 9 0.0836862
USP3 ubiquitin specific peptidase 3 0.0795343
SMAD3 SMAD family member 3 0.0775608
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0702627
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0682966
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0669779
SOD2 superoxide dismutase 2, mitochondrial 0.0608469
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0586978
PCBP2 poly(rC) binding protein 2 0.0586148
HELZ helicase with zinc finger 0.0576577
GRB10 growth factor receptor-bound protein 10 0.0573119
LDHA lactate dehydrogenase A 0.055854
ADAM17 ADAM metallopeptidase domain 17 0.0530427
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.048725
TNIP1 TNFAIP3 interacting protein 1 0.0458883
PKM pyruvate kinase, muscle 0.0451779
BIRC6 baculoviral IAP repeat containing 6 0.0447092
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0439487
MYO1B myosin IB 0.0437294
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0434794
NUP58 nucleoporin 58 0.0417932
ARHGAP26 Rho GTPase activating protein 26 0.0410925
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0409027
NAMPT nicotinamide phosphoribosyltransferase 0.0407841
FMNL2 formin-like 2 0.0405662
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0395921
ARL5B ADP-ribosylation factor-like 5B 0.0389484
GOLGA4 golgin A4 0.038426
RICTOR RPTOR independent companion of MTOR, complex 2 0.0369864
RTN4 reticulon 4 0.0364307
COPA coatomer protein complex, subunit alpha 0.0363333
RB1CC1 RB1-inducible coiled-coil 1 0.0362315
WAC WW domain containing adaptor with coiled-coil 0.0359185
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0352158
AXL AXL receptor tyrosine kinase 0.034833
CCNL1 cyclin L1 0.0347422
EEF2 eukaryotic translation elongation factor 2 0.0346156
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0341962
NRIP1 nuclear receptor interacting protein 1 0.0340347
NBAS neuroblastoma amplified sequence 0.0339763
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0330489
ANKRD11 ankyrin repeat domain 11 0.033005
RAB1A RAB1A, member RAS oncogene family 0.0329458
DGKD diacylglycerol kinase, delta 130kDa 0.0329292
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0327745
RBM39 RNA binding motif protein 39 0.0325108
FAM13A family with sequence similarity 13, member A 0.0319998
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0319089
TFG TRK-fused gene 0.0315049
FAM107B family with sequence similarity 107, member B 0.0313647
MSN moesin 0.0311993
KCTD9 potassium channel tetramerization domain containing 9 0.0311871
TXNRD1 thioredoxin reductase 1 0.0311674
UBC ubiquitin C 0.0311113
UBA6 ubiquitin-like modifier activating enzyme 6 0.03063
WDR43 WD repeat domain 43 0.0306272
CEMIP cell migration inducing protein, hyaluronan binding 0.0302014
KMT2E lysine (K)-specific methyltransferase 2E 0.02948
DENND4C DENN/MADD domain containing 4C 0.0290923
ZNF292 zinc finger protein 292 0.0290122
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0281221
ECPAS Ecm29 proteasome adaptor and scaffold 0.0278858
SUCO SUN domain containing ossification factor 0.0272611
CMIP c-Maf inducing protein 0.0272381
USP9X ubiquitin specific peptidase 9, X-linked 0.0270445
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0266427
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.026625
TBK1 TANK-binding kinase 1 0.0260862
MYH9 myosin, heavy chain 9, non-muscle 0.0251562
QKI QKI, KH domain containing, RNA binding 0.0249192
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0247869
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0246899
MCL1 myeloid cell leukemia 1 0.02454
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0244798
ADAM9 ADAM metallopeptidase domain 9 0.0244012
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0243147
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0242592
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0242103
RNF145 ring finger protein 145 0.0240602
AGFG1 ArfGAP with FG repeats 1 0.0238406
C1D C1D nuclear receptor corepressor 0.0238122
PTK2 protein tyrosine kinase 2 0.0237946
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0234963
PDIA6 protein disulfide isomerase family A, member 6 0.0233924
ATP13A3 ATPase type 13A3 0.0233512
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0233504
ELL2 elongation factor, RNA polymerase II, 2 0.0233412
SP3 Sp3 transcription factor 0.0231379
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0230509
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0230203
SRP54 signal recognition particle 54kDa 0.0228235
USP34 ubiquitin specific peptidase 34 0.0227814
KDM2A lysine (K)-specific demethylase 2A 0.0226829
TNS1 tensin 1 0.0226647

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.249112
MT2A metallothionein 2A -0.23392
RPS19 ribosomal protein S19 -0.134062
VIM vimentin -0.129358
RPLP1 ribosomal protein, large, P1 -0.118007
ACTG1 actin gamma 1 -0.111094
FTL ferritin, light polypeptide -0.100595
TPT1 tumor protein, translationally-controlled 1 -0.0830988
RPL23 ribosomal protein L23 -0.0797572
RPL26 ribosomal protein L26 -0.0786388
TM4SF1 transmembrane 4 L six family member 1 -0.0776794
RPS16 ribosomal protein S16 -0.0705003
MT1X metallothionein 1X -0.069277
RPS6 ribosomal protein S6 -0.0685682
EIF1 eukaryotic translation initiation factor 1 -0.0664722
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0654306
RPL12 ribosomal protein L12 -0.0646612
RPS3 ribosomal protein S3 -0.063059
RPS24 ribosomal protein S24 -0.0621572
PDE4D phosphodiesterase 4D, cAMP-specific -0.0612446
KRT81 keratin 81, type II -0.0607374
RPLP2 ribosomal protein, large, P2 -0.059245
RPL19 ribosomal protein L19 -0.0576399
RPL37A ribosomal protein L37a -0.0547695
RPL35A ribosomal protein L35a -0.054061
RPS27A ribosomal protein S27a -0.0529546
RPS8 ribosomal protein S8 -0.052811
PTMA prothymosin, alpha -0.0504408
RPS17 ribosomal protein S17 -0.0476659
RPS29 ribosomal protein S29 -0.0454522
RPL7A ribosomal protein L7a -0.0453252
SLC35F3 solute carrier family 35, member F3 -0.0445876
RPL13A ribosomal protein L13a -0.0440515
NAP1L1 nucleosome assembly protein 1-like 1 -0.0425103
RPS12 ribosomal protein S12 -0.0413355
RPL31 ribosomal protein L31 -0.0405873
VCL vinculin -0.0400583
EFNA5 ephrin-A5 -0.0399646
HMGA2 high mobility group AT-hook 2 -0.0396208
BASP1 brain abundant, membrane attached signal protein 1 -0.0386298
RPL36A ribosomal protein L36a -0.0385696
RPL18 ribosomal protein L18 -0.0375521
RPS13 ribosomal protein S13 -0.0369505
RPL34 ribosomal protein L34 -0.0368298
S100A6 S100 calcium binding protein A6 -0.0363647
RPL32 ribosomal protein L32 -0.0363264
RPL28 ribosomal protein L28 -0.0361325
ALCAM activated leukocyte cell adhesion molecule -0.0354748
RPL9 ribosomal protein L9 -0.0346689
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.03366
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0335954
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0331667
RPL38 ribosomal protein L38 -0.032758
RPL36 ribosomal protein L36 -0.0327186
KYNU kynureninase -0.0319203
THSD4 thrombospondin, type I, domain containing 4 -0.031807
RPL35 ribosomal protein L35 -0.0317535
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0316475
STC1 stanniocalcin 1 -0.0315164
S100A10 S100 calcium binding protein A10 -0.0313142
RPL11 ribosomal protein L11 -0.0310343
RACK1 receptor for activated C kinase 1 -0.030637
RPL8 ribosomal protein L8 -0.0303762
RPS23 ribosomal protein S23 -0.0303457
RPS11 ribosomal protein S11 -0.0302964
MAML3 mastermind-like 3 (Drosophila) -0.0300282
RPL7 ribosomal protein L7 -0.0290537
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0285943
EGFR epidermal growth factor receptor -0.0279489
RPS25 ribosomal protein S25 -0.0274545
RPL37 ribosomal protein L37 -0.0274526
INTS6 integrator complex subunit 6 -0.0273959
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0271956
KLF6 Kruppel-like factor 6 -0.0270228
RPL5 ribosomal protein L5 -0.0267407
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0267043
CAVIN1 caveolae associated protein 1 -0.026626
RPL30 ribosomal protein L30 -0.0265796
AADAC arylacetamide deacetylase -0.0264256
RPS21 ribosomal protein S21 -0.0260119
RPS27 ribosomal protein S27 -0.0256643
NACA nascent polypeptide-associated complex alpha subunit -0.0255823
RPLP0 ribosomal protein, large, P0 -0.0253183
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0251784
RPL27 ribosomal protein L27 -0.0250047
RPS14 ribosomal protein S14 -0.0249294
AHNAK AHNAK nucleoprotein -0.024783
BTG1 B-cell translocation gene 1, anti-proliferative -0.0245224
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0243979
PRKCA protein kinase C, alpha -0.0242843
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0240306
RPS4X ribosomal protein S4, X-linked -0.0236956
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0236462
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0235998
C15ORF48 chromosome 15 open reading frame 48 -0.0231991
EIF5B eukaryotic translation initiation factor 5B -0.0229551
IGFBP4 insulin-like growth factor binding protein 4 -0.0223725
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0222167
LMNA lamin A/C -0.0220936
AHNAK2 AHNAK nucleoprotein 2 -0.0220163