Sivelestat (sodium tetrahydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 0.170463
PRKG1 protein kinase, cGMP-dependent, type I 0.140341
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.130148
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0976582
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0901872
JMJD1C jumonji domain containing 1C 0.0764708
FNDC3B fibronectin type III domain containing 3B 0.0717244
ZEB1 zinc finger E-box binding homeobox 1 0.0698474
MED13L mediator complex subunit 13-like 0.0698238
CTBP2 C-terminal binding protein 2 0.0651061
ZFAND3 zinc finger, AN1-type domain 3 0.0642192
VEGFA vascular endothelial growth factor A 0.0637328
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0619975
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0599146
TRIO trio Rho guanine nucleotide exchange factor 0.0552131
KMT2C lysine (K)-specific methyltransferase 2C 0.0550374
AFF4 AF4/FMR2 family, member 4 0.0540828
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0535614
SEPTIN11 septin 11 0.0524472
GMDS GDP-mannose 4,6-dehydratase 0.0503275
KDM6A lysine (K)-specific demethylase 6A 0.0486655
HMGA2 high mobility group AT-hook 2 0.0485711
MYOF myoferlin 0.0478744
NCOR2 nuclear receptor corepressor 2 0.0461286
SIK3 SIK family kinase 3 0.0447841
ZMIZ1 zinc finger, MIZ-type containing 1 0.0443076
KAZN kazrin, periplakin interacting protein 0.0438382
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0433438
IGF2R insulin-like growth factor 2 receptor 0.0416346
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0414666
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.041257
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0386726
SPPL3 signal peptide peptidase like 3 0.0385891
PICALM phosphatidylinositol binding clathrin assembly protein 0.0385124
ANKHD1 ankyrin repeat and KH domain containing 1 0.0377462
NBEA neurobeachin 0.0377434
KDM4C lysine (K)-specific demethylase 4C 0.0375044
PDS5B PDS5 cohesin associated factor B 0.0374539
LPP LIM domain containing preferred translocation partner in lipoma 0.0373645
USP9X ubiquitin specific peptidase 9, X-linked 0.0373022
ZFHX3 zinc finger homeobox 3 0.0371821
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.036559
EGFR epidermal growth factor receptor 0.0362536
ERBIN erbb2 interacting protein 0.0353978
SBF2 SET binding factor 2 0.0353431
PDGFC platelet derived growth factor C 0.0352961
ANO6 anoctamin 6 0.0349573
PARD3 par-3 family cell polarity regulator 0.0343042
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0341326
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0335513
GLS2 glutaminase 2 (liver, mitochondrial) 0.0331175
FLNB filamin B, beta 0.0328219
GOLGA4 golgin A4 0.0327357
PKM pyruvate kinase, muscle 0.0325818
RAB7A RAB7A, member RAS oncogene family 0.0325052
PCBP2 poly(rC) binding protein 2 0.0324784
JARID2 jumonji, AT rich interactive domain 2 0.032097
PIAS2 protein inhibitor of activated STAT, 2 0.0317387
ANKRD12 ankyrin repeat domain 12 0.0312203
ARHGAP12 Rho GTPase activating protein 12 0.0311876
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.031153
MSRB3 methionine sulfoxide reductase B3 0.0311459
ATXN2 ataxin 2 0.030977
SERTAD2 SERTA domain containing 2 0.0305859
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0304682
BIRC6 baculoviral IAP repeat containing 6 0.0299851
PGK1 phosphoglycerate kinase 1 0.0297997
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0296667
YAP1 Yes-associated protein 1 0.0292484
ACACA acetyl-CoA carboxylase alpha 0.029208
RBM33 RNA binding motif protein 33 0.0290818
FAM168A family with sequence similarity 168, member A 0.0289888
APLP2 amyloid beta (A4) precursor-like protein 2 0.0288541
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0288455
RCOR1 REST corepressor 1 0.0287483
KMT2E lysine (K)-specific methyltransferase 2E 0.0286665
SND1 staphylococcal nuclease and tudor domain containing 1 0.0285309
CLIP2 CAP-GLY domain containing linker protein 2 0.0285163
QKI QKI, KH domain containing, RNA binding 0.0284975
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0283367
FAM13A family with sequence similarity 13, member A 0.0283359
RHEB Ras homolog enriched in brain 0.028302
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0282751
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0281659
NUP58 nucleoporin 58 0.0280129
FMNL2 formin-like 2 0.0280067
NBAS neuroblastoma amplified sequence 0.0278692
PRKCE protein kinase C, epsilon 0.0278312
ANKRD11 ankyrin repeat domain 11 0.0274223
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0273816
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.027341
IPO7 importin 7 0.0273237
CDK8 cyclin-dependent kinase 8 0.0271963
PUM2 pumilio RNA-binding family member 2 0.0271256
DMXL1 Dmx-like 1 0.0269112
ADIPOR2 adiponectin receptor 2 0.026835
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0266494
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0265704
BBX bobby sox homolog (Drosophila) 0.0264846
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0264351

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.194512
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0789141
PTMA prothymosin, alpha -0.0751139
SOX4 SRY (sex determining region Y)-box 4 -0.0680049
TMSB4X thymosin beta 4, X-linked -0.0633778
RPLP1 ribosomal protein, large, P1 -0.0576148
RPLP0 ribosomal protein, large, P0 -0.0565882
RPS6 ribosomal protein S6 -0.0562795
CENPF centromere protein F, 350/400kDa -0.0553898
MGP matrix Gla protein -0.053341
MEST mesoderm specific transcript -0.0475041
TMSB10 thymosin beta 10 -0.0474265
MT2A metallothionein 2A -0.0471787
IER3 immediate early response 3 -0.0442227
TPT1 tumor protein, translationally-controlled 1 -0.0411052
RPL12 ribosomal protein L12 -0.0409573
RPL26 ribosomal protein L26 -0.0400591
RPL23 ribosomal protein L23 -0.039132
TUBB tubulin, beta class I -0.0383794
RPLP2 ribosomal protein, large, P2 -0.0373488
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0363612
RPS27A ribosomal protein S27a -0.0344796
RACK1 receptor for activated C kinase 1 -0.0339144
RPS24 ribosomal protein S24 -0.033892
RPL35A ribosomal protein L35a -0.0331529
COL1A2 collagen, type I, alpha 2 -0.0326997
RPS19 ribosomal protein S19 -0.0325151
HMGB1 high mobility group box 1 -0.0319086
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0318918
HMGB2 high mobility group box 2 -0.0315226
RPS8 ribosomal protein S8 -0.0291839
FTL ferritin, light polypeptide -0.0289495
RPL11 ribosomal protein L11 -0.0288763
RPL36 ribosomal protein L36 -0.0285334
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0283961
RPS14 ribosomal protein S14 -0.0283347
EIF1 eukaryotic translation initiation factor 1 -0.0281769
RAD21 RAD21 homolog (S. pombe) -0.0277222
SMC3 structural maintenance of chromosomes 3 -0.0274655
RPL5 ribosomal protein L5 -0.0269867
SQSTM1 sequestosome 1 -0.0269374
LMO4 LIM domain only 4 -0.0262478
RPS3 ribosomal protein S3 -0.0257869
RPL34 ribosomal protein L34 -0.025655
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0251377
RPL19 ribosomal protein L19 -0.0246765
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0243295
RPS21 ribosomal protein S21 -0.023994
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0232971
PNISR PNN-interacting serine/arginine-rich protein -0.0231858
RPS12 ribosomal protein S12 -0.023095
RPL35 ribosomal protein L35 -0.0229159
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0227307
RPS4X ribosomal protein S4, X-linked -0.0226456
RPS15 ribosomal protein S15 -0.0224102
FOXC1 forkhead box C1 -0.0223151
RPL37 ribosomal protein L37 -0.022282
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0222488
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0218169
RPL7 ribosomal protein L7 -0.0217936
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0217404
TPI1 triosephosphate isomerase 1 -0.021305
RPS5 ribosomal protein S5 -0.0212947
MKI67 marker of proliferation Ki-67 -0.0212334
AKR1C1 aldo-keto reductase family 1, member C1 -0.0206648
KNL1 kinetochore scaffold 1 -0.0203155
KPNB1 karyopherin (importin) beta 1 -0.0198767
B2M beta-2-microglobulin -0.0197281
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0195919
UBB ubiquitin B -0.0189819
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0189331
WBP11 WW domain binding protein 11 -0.0184231
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0183717
CCNI cyclin I -0.0181682
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0181377
SMC4 structural maintenance of chromosomes 4 -0.0180828
GPX4 glutathione peroxidase 4 -0.0177386
MIS18BP1 MIS18 binding protein 1 -0.0177161
S100A9 S100 calcium binding protein A9 -0.0172446
MEOX2 mesenchyme homeobox 2 -0.0170502
NUSAP1 nucleolar and spindle associated protein 1 -0.0170407
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0169658
CCAR1 cell division cycle and apoptosis regulator 1 -0.0169102
H1-4 H1.4 linker histone, cluster member -0.0168645
RPL37A ribosomal protein L37a -0.0166356
RPL30 ribosomal protein L30 -0.0166012
SLF2 SMC5-SMC6 complex localization factor 2 -0.0164019
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.016281
ZBTB20 zinc finger and BTB domain containing 20 -0.0162708
RPS13 ribosomal protein S13 -0.0160744
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -0.016011
RPL13A ribosomal protein L13a -0.0160062
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0159604
ACTG1 actin gamma 1 -0.0156221
RPL9 ribosomal protein L9 -0.0155856
FTH1 ferritin, heavy polypeptide 1 -0.0154758
NEMF nuclear export mediator factor -0.0154587
AKR1C2 aldo-keto reductase family 1, member C2 -0.0154514
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0153378
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0152751