| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.12578 |
| ASPH | aspartate beta-hydroxylase | 0.0905223 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0741712 |
| CEP250 | centrosomal protein 250kDa | 0.0676195 |
| VMP1 | vacuole membrane protein 1 | 0.0612743 |
| CLTC | clathrin, heavy chain (Hc) | 0.0564385 |
| SMYD3 | SET and MYND domain containing 3 | 0.0561877 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0556047 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0537053 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0535818 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0528581 |
| CDK12 | cyclin-dependent kinase 12 | 0.0520989 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0512436 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0488758 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0441763 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0388519 |
| APP | amyloid beta (A4) precursor protein | 0.0358331 |
| LDHA | lactate dehydrogenase A | 0.0352729 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0351354 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0327569 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0327505 |
| PTK2 | protein tyrosine kinase 2 | 0.0317321 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0305755 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0302488 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0290002 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0276573 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0276048 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0271676 |
| RAD51B | RAD51 paralog B | 0.0269912 |
| VCP | valosin containing protein | 0.0266057 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0260968 |
| AHNAK | AHNAK nucleoprotein | 0.0260273 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | 0.0255078 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0253318 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0252886 |
| ENO1 | enolase 1, (alpha) | 0.0251045 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0249564 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.024632 |
| CANX | calnexin | 0.0238506 |
| PGK1 | phosphoglycerate kinase 1 | 0.0237704 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.0233054 |
| MCL1 | myeloid cell leukemia 1 | 0.0230494 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0230088 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0229855 |
| LASP1 | LIM and SH3 protein 1 | 0.0228672 |
| DSPP | dentin sialophosphoprotein | 0.0227066 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0226126 |
| SBF2 | SET binding factor 2 | 0.022197 |
| ATXN1 | ataxin 1 | 0.0219975 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0219955 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0219798 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0216617 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0215803 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0215442 |
| DENND1A | DENN/MADD domain containing 1A | 0.021183 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.020614 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.020406 |
| ANXA2 | annexin A2 | 0.0204026 |
| AHR | aryl hydrocarbon receptor | 0.0200523 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0200189 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0199724 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0199414 |
| PLEC | plectin | 0.0196266 |
| NDRG1 | N-myc downstream regulated 1 | 0.0196237 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0195507 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0194821 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0193945 |
| ITGB6 | integrin, beta 6 | 0.01936 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0192305 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0189591 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0188179 |
| DTNA | dystrobrevin, alpha | 0.0187869 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0183287 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0183221 |
| YAP1 | Yes-associated protein 1 | 0.0179817 |
| BBX | bobby sox homolog (Drosophila) | 0.0179089 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0178407 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0176724 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0176263 |
| NEBL | nebulette | 0.0175195 |
| TMEM123 | transmembrane protein 123 | 0.0174909 |
| MYO5B | myosin VB | 0.0173891 |
| MYOF | myoferlin | 0.0173871 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.0172469 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0172212 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.017214 |
| FAM168A | family with sequence similarity 168, member A | 0.0171281 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0171135 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0170391 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.0168735 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0168622 |
| TPD52 | tumor protein D52 | 0.0166918 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0166698 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0166278 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0165923 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0165424 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0164994 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0164863 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0164805 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0163887 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0526039 |
| RPL23 | ribosomal protein L23 | -0.0455381 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0426034 |
| RPL19 | ribosomal protein L19 | -0.0320198 |
| PTMA | prothymosin, alpha | -0.0302946 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.029893 |
| S100A8 | S100 calcium binding protein A8 | -0.0293669 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0290851 |
| TMSB10 | thymosin beta 10 | -0.0289615 |
| S100A9 | S100 calcium binding protein A9 | -0.0253561 |
| RPL35A | ribosomal protein L35a | -0.0233883 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.022556 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0201819 |
| AREG | amphiregulin | -0.0190438 |
| RPS19 | ribosomal protein S19 | -0.0175735 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0171185 |
| FTL | ferritin, light polypeptide | -0.0169751 |
| ACTG1 | actin gamma 1 | -0.0164589 |
| RPS6 | ribosomal protein S6 | -0.0162161 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0161251 |
| B2M | beta-2-microglobulin | -0.0159034 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0158483 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0152423 |
| S100A14 | S100 calcium binding protein A14 | -0.0145796 |
| RPS8 | ribosomal protein S8 | -0.014224 |
| RPL12 | ribosomal protein L12 | -0.0141911 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0141877 |
| S100A6 | S100 calcium binding protein A6 | -0.0139505 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0130705 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0125578 |
| RPS29 | ribosomal protein S29 | -0.0121168 |
| RPS27 | ribosomal protein S27 | -0.0121121 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.011918 |
| RPL8 | ribosomal protein L8 | -0.011829 |
| HMGB1 | high mobility group box 1 | -0.0116788 |
| EGR1 | early growth response 1 | -0.011337 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0113122 |
| RPLP1 | ribosomal protein, large, P1 | -0.0112613 |
| RPL35 | ribosomal protein L35 | -0.0111057 |
| RPL36 | ribosomal protein L36 | -0.0110555 |
| RPL26 | ribosomal protein L26 | -0.0109476 |
| RPL32 | ribosomal protein L32 | -0.010919 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0108186 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0106499 |
| S100A7 | S100 calcium binding protein A7 | -0.0105222 |
| RPL9 | ribosomal protein L9 | -0.010353 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0102245 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0102147 |
| VIM | vimentin | -0.00982277 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00977208 |
| RPL37 | ribosomal protein L37 | -0.00969064 |
| RPL34 | ribosomal protein L34 | -0.00945544 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.00931302 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.00894438 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.00893615 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -0.00890798 |
| GNAS | GNAS complex locus | -0.00890101 |
| SET | SET nuclear proto-oncogene | -0.00879323 |
| RPS13 | ribosomal protein S13 | -0.00870794 |
| MT1X | metallothionein 1X | -0.00866063 |
| RPL30 | ribosomal protein L30 | -0.00856554 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.00854624 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00847517 |
| RPS12 | ribosomal protein S12 | -0.00847126 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00841494 |
| RPLP2 | ribosomal protein, large, P2 | -0.00838258 |
| RPL28 | ribosomal protein L28 | -0.00838139 |
| MIEN1 | migration and invasion enhancer 1 | -0.00836008 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.00833292 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00824512 |
| RPS16 | ribosomal protein S16 | -0.00821409 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.00813614 |
| RPS27A | ribosomal protein S27a | -0.00802632 |
| RPS21 | ribosomal protein S21 | -0.00788181 |
| KLF6 | Kruppel-like factor 6 | -0.00780675 |
| RPS23 | ribosomal protein S23 | -0.00780666 |
| GPC5 | glypican 5 | -0.00759777 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.00744289 |
| LMNA | lamin A/C | -0.00739763 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.00738728 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00734849 |
| CCNI | cyclin I | -0.0073235 |
| S100P | S100 calcium binding protein P | -0.00729723 |
| ZFP36 | ZFP36 ring finger protein | -0.0072951 |
| RPL37A | ribosomal protein L37a | -0.00724496 |
| RPS3 | ribosomal protein S3 | -0.00722789 |
| PFDN4 | prefoldin subunit 4 | -0.00718792 |
| RPL11 | ribosomal protein L11 | -0.00714355 |
| RPL36A | ribosomal protein L36a | -0.00712171 |
| SERF2 | small EDRK-rich factor 2 | -0.00706234 |
| COX6C | cytochrome c oxidase subunit VIc | -0.0069993 |
| RPS15 | ribosomal protein S15 | -0.00699429 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.00698281 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.00697055 |
| SEPTIN7 | septin 7 | -0.00695628 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.00683735 |
| RPS20 | ribosomal protein S20 | -0.00672094 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.00664994 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00664921 |
| S100A11 | S100 calcium binding protein A11 | -0.00656216 |
