| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.141652 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.115397 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.114733 |
| COL5A2 | collagen, type V, alpha 2 | 0.101209 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0921699 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.091652 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0894079 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0847163 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0827291 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0792056 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0790043 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.077869 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0761776 |
| NUP58 | nucleoporin 58 | 0.0688189 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0686092 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0678171 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0641621 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0635909 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0628506 |
| SMYD3 | SET and MYND domain containing 3 | 0.0622471 |
| AUTS2 | autism susceptibility candidate 2 | 0.0580542 |
| CABIN1 | calcineurin binding protein 1 | 0.0554892 |
| JMJD1C | jumonji domain containing 1C | 0.0546609 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.053188 |
| HELZ | helicase with zinc finger | 0.0527729 |
| FOXO3 | forkhead box O3 | 0.0523922 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0511025 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0500116 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0499387 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0490305 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0487009 |
| ZNF608 | zinc finger protein 608 | 0.0478807 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0477246 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0471589 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0470256 |
| LDHA | lactate dehydrogenase A | 0.0469108 |
| PCBP2 | poly(rC) binding protein 2 | 0.0462512 |
| TOX | thymocyte selection-associated high mobility group box | 0.0448913 |
| OGA | O-GlcNAcase | 0.0448267 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0438866 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0436028 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0432795 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0430479 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0424417 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0424258 |
| PHIP | pleckstrin homology domain interacting protein | 0.0417512 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0414264 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0410773 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0408908 |
| CDC73 | cell division cycle 73 | 0.0408525 |
| RAD51B | RAD51 paralog B | 0.0405681 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0402622 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0400815 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0399163 |
| ATRN | attractin | 0.039722 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0396965 |
| WDR45B | WD repeat domain 45B | 0.0389893 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0389391 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0387759 |
| FAM168A | family with sequence similarity 168, member A | 0.0386069 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0385625 |
| FBXO11 | F-box protein 11 | 0.0383164 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0381364 |
| ZNF292 | zinc finger protein 292 | 0.0380809 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0380099 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | 0.0379369 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0378939 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0378293 |
| BBX | bobby sox homolog (Drosophila) | 0.0376617 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0376077 |
| RNF145 | ring finger protein 145 | 0.0374889 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0374727 |
| VCL | vinculin | 0.0369337 |
| SRPK2 | SRSF protein kinase 2 | 0.0369099 |
| HOMER1 | homer scaffolding protein 1 | 0.0366874 |
| CADM2 | cell adhesion molecule 2 | 0.0364684 |
| CDH18 | cadherin 18, type 2 | 0.0364613 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0364509 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0364226 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0359873 |
| USP34 | ubiquitin specific peptidase 34 | 0.0348385 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.034598 |
| PCM1 | pericentriolar material 1 | 0.0343363 |
| RYBP | RING1 and YY1 binding protein | 0.0342998 |
| XPO1 | exportin 1 | 0.0342177 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0340887 |
| RTN4 | reticulon 4 | 0.0336125 |
| SYAP1 | synapse associated protein 1 | 0.0334926 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0334785 |
| TBK1 | TANK-binding kinase 1 | 0.0332239 |
| EFNA5 | ephrin-A5 | 0.0324013 |
| YAP1 | Yes-associated protein 1 | 0.0323379 |
| PARD3 | par-3 family cell polarity regulator | 0.0322541 |
| ZNF638 | zinc finger protein 638 | 0.0320369 |
| NBEAL1 | neurobeachin-like 1 | 0.0318576 |
| QKI | QKI, KH domain containing, RNA binding | 0.0315798 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0315048 |
| SERTAD2 | SERTA domain containing 2 | 0.0312116 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0311917 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0311161 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0914399 |
| RPS8 | ribosomal protein S8 | -0.0751973 |
| RPL37A | ribosomal protein L37a | -0.0664022 |
| RPS6 | ribosomal protein S6 | -0.0663499 |
| TMSB10 | thymosin beta 10 | -0.0568995 |
| RPL26 | ribosomal protein L26 | -0.0517808 |
| PTMA | prothymosin, alpha | -0.0511375 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0480948 |
| RPLP2 | ribosomal protein, large, P2 | -0.0478891 |
| RPL35A | ribosomal protein L35a | -0.0476519 |
| RPS12 | ribosomal protein S12 | -0.0463376 |
| RPS19 | ribosomal protein S19 | -0.0447105 |
| ACTG1 | actin gamma 1 | -0.0442479 |
| RPLP1 | ribosomal protein, large, P1 | -0.0441781 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0415336 |
| RPS3 | ribosomal protein S3 | -0.0414767 |
| SET | SET nuclear proto-oncogene | -0.0386938 |
| RPS24 | ribosomal protein S24 | -0.0385007 |
| RPL9 | ribosomal protein L9 | -0.0384651 |
| RPS27A | ribosomal protein S27a | -0.0377441 |
| RPS21 | ribosomal protein S21 | -0.0360027 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0331598 |
| CENPF | centromere protein F, 350/400kDa | -0.0327834 |
| RPS4X | ribosomal protein S4, X-linked | -0.0326898 |
| MKI67 | marker of proliferation Ki-67 | -0.0318656 |
| ATP11A | ATPase, class VI, type 11A | -0.0308864 |
| RACK1 | receptor for activated C kinase 1 | -0.0302374 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0302168 |
| RPL11 | ribosomal protein L11 | -0.0301754 |
| RPL34 | ribosomal protein L34 | -0.0291443 |
| RPL36A | ribosomal protein L36a | -0.0280753 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0280567 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0275442 |
| RPL12 | ribosomal protein L12 | -0.0275279 |
| RPL23 | ribosomal protein L23 | -0.0273174 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0272916 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0268424 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0266783 |
| RPLP0 | ribosomal protein, large, P0 | -0.0266382 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.026503 |
| RPL38 | ribosomal protein L38 | -0.0264625 |
| RPS13 | ribosomal protein S13 | -0.0259988 |
| RPS17 | ribosomal protein S17 | -0.0251638 |
| RPS29 | ribosomal protein S29 | -0.0248273 |
| RPL19 | ribosomal protein L19 | -0.02462 |
| HMGB1 | high mobility group box 1 | -0.0245521 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0237914 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0233183 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0232094 |
| RPL37 | ribosomal protein L37 | -0.0227812 |
| RPL7A | ribosomal protein L7a | -0.0226993 |
| RPS28 | ribosomal protein S28 | -0.0225555 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -0.022371 |
| RPS5 | ribosomal protein S5 | -0.0219758 |
| NEBL | nebulette | -0.0218032 |
| RPS25 | ribosomal protein S25 | -0.0217243 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0217075 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0216076 |
| GNAS | GNAS complex locus | -0.0212902 |
| RPL13A | ribosomal protein L13a | -0.0211972 |
| RPL5 | ribosomal protein L5 | -0.0207727 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.020703 |
| RPL35 | ribosomal protein L35 | -0.0207027 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0206638 |
| UBTF | upstream binding transcription factor, RNA polymerase I | -0.0204686 |
| LDHB | lactate dehydrogenase B | -0.020319 |
| RPL36 | ribosomal protein L36 | -0.0198637 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0196015 |
| RPS11 | ribosomal protein S11 | -0.019488 |
| RPS16 | ribosomal protein S16 | -0.0194832 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0191169 |
| MAP4 | microtubule-associated protein 4 | -0.0185151 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0184864 |
| PRDX1 | peroxiredoxin 1 | -0.0183686 |
| ATF4 | activating transcription factor 4 | -0.0183453 |
| RPS10 | ribosomal protein S10 | -0.0178817 |
| RPL31 | ribosomal protein L31 | -0.0177213 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0176152 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0172049 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0171987 |
| MAGEA4 | melanoma antigen family A4 | -0.0171695 |
| RPL10A | ribosomal protein L10a | -0.0171692 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0167891 |
| RPL27 | ribosomal protein L27 | -0.0165205 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0165033 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0164069 |
| RBM25 | RNA binding motif protein 25 | -0.0162834 |
| RPL4 | ribosomal protein L4 | -0.016241 |
| RPS2 | ribosomal protein S2 | -0.0161688 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0161104 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.016106 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -0.0157978 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0157599 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0157344 |
| RPL30 | ribosomal protein L30 | -0.0157144 |
| RPS14 | ribosomal protein S14 | -0.0156215 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0155706 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.0154926 |
| EXOC4 | exocyst complex component 4 | -0.0154652 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.0152491 |
