Sivelestat (sodium tetrahydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.23399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.113881
PDIA4 protein disulfide isomerase family A, member 4 0.113061
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0884745
NAMPT nicotinamide phosphoribosyltransferase 0.0757117
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0527232
LEF1 lymphoid enhancer-binding factor 1 0.0481404
TMEM178B transmembrane protein 178B 0.0471087
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0466947
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0444669
PRELID2 PRELI domain containing 2 0.0413425
CALR calreticulin 0.0381902
EGLN1 egl-9 family hypoxia-inducible factor 1 0.038099
ESYT2 extended synaptotagmin-like protein 2 0.0380794
APP amyloid beta (A4) precursor protein 0.0379008
NBAS neuroblastoma amplified sequence 0.0356677
CANX calnexin 0.0355684
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0309286
CDC73 cell division cycle 73 0.027435
TAC4 tachykinin 4 (hemokinin) 0.0271221
ZYX zyxin 0.026874
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0265742
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.025776
CHSY1 chondroitin sulfate synthase 1 0.0249445
VGF VGF nerve growth factor inducible 0.0241285
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0238965
ARRDC3 arrestin domain containing 3 0.0238781
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0237268
LOC112694756 uncharaterized LOC112694756 0.0235496
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0233024
MCL1 myeloid cell leukemia 1 0.023037
FNDC3B fibronectin type III domain containing 3B 0.022881
PDE4D phosphodiesterase 4D, cAMP-specific 0.0227769
IL1RAP interleukin 1 receptor accessory protein 0.0227698
AFDN afadin, adherens junction formation factor 0.0213898
LRMDA leucine rich melanocyte differentiation associated 0.0213462
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0213461
COG5 component of oligomeric golgi complex 5 0.021142
FMNL2 formin-like 2 0.0209165
RNF145 ring finger protein 145 0.0204681
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0203897
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0201376
MACF1 microtubule-actin crosslinking factor 1 0.0200289
SPRED1 sprouty-related, EVH1 domain containing 1 0.0200233
COPA coatomer protein complex, subunit alpha 0.0195024
NHSL1 NHS-like 1 0.0194035
PYGB phosphorylase, glycogen; brain 0.0188706
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0188407
ZFAND3 zinc finger, AN1-type domain 3 0.0187909
HOOK2 hook microtubule-tethering protein 2 0.0185135
ERRFI1 ERBB receptor feedback inhibitor 1 0.0184727
FLNB filamin B, beta 0.0182118
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0179925
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0179761
RBM33 RNA binding motif protein 33 0.0179409
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0177021
IFRD1 interferon-related developmental regulator 1 0.017613
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0169819
MIDEAS mitotic deacetylase associated SANT domain protein 0.0166332
HYOU1 hypoxia up-regulated 1 0.0166216
UBE2H ubiquitin-conjugating enzyme E2H 0.0166098
NEK7 NIMA-related kinase 7 0.0164508
PICALM phosphatidylinositol binding clathrin assembly protein 0.0162535
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.016162
EXOC4 exocyst complex component 4 0.0160822
VGLL4 vestigial-like family member 4 0.0159611
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0156186
IGF1R insulin-like growth factor 1 receptor 0.0155969
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0155047
INSIG2 insulin induced gene 2 0.0152616
HELZ helicase with zinc finger 0.0152041
KDM3A lysine (K)-specific demethylase 3A 0.0150802
MYH9 myosin, heavy chain 9, non-muscle 0.0150274
FBXO7 F-box protein 7 0.0149866
USP9X ubiquitin specific peptidase 9, X-linked 0.0145788
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0144621
RASA3 RAS p21 protein activator 3 0.0142342
UBA6 ubiquitin-like modifier activating enzyme 6 0.0139908
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0139675
BTBD9 BTB (POZ) domain containing 9 0.0139261
SOX13 SRY (sex determining region Y)-box 13 0.0138656
MBD5 methyl-CpG binding domain protein 5 0.0137771
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0137402
AHNAK AHNAK nucleoprotein 0.0136908
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0135318
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0133845
RBM39 RNA binding motif protein 39 0.0133103
CAPRIN1 cell cycle associated protein 1 0.0132666
KMT2E lysine (K)-specific methyltransferase 2E 0.013116
VMP1 vacuole membrane protein 1 0.0129533
CDK19 cyclin-dependent kinase 19 0.0129273
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0129089
NIBAN2 niban apoptosis regulator 2 0.0128459
TOP2B topoisomerase (DNA) II beta 180kDa 0.0126475
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0126151
SPAG9 sperm associated antigen 9 0.0125557
AFAP1 actin filament associated protein 1 0.0125438
RNF150 ring finger protein 150 0.0125073
SMYD3 SET and MYND domain containing 3 0.0124205
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0123896

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.341829
VIM vimentin -0.240863
IGFBP5 insulin-like growth factor binding protein 5 -0.133619
S100A6 S100 calcium binding protein A6 -0.10074
TMSB10 thymosin beta 10 -0.0932731
GPC6 glypican 6 -0.0864979
ACTG1 actin gamma 1 -0.0844552
HLA-B major histocompatibility complex, class I, B -0.0792353
CALD1 caldesmon 1 -0.0667279
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0639528
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0622933
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0617264
DCT dopachrome tautomerase -0.055202
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0543034
NLGN1 neuroligin 1 -0.052355
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0473442
FRMD4A FERM domain containing 4A -0.0469909
S100A9 S100 calcium binding protein A9 -0.0467192
FMN1 formin 1 -0.04616
POTEF POTE ankyrin domain family, member F -0.0459986
AKAP12 A kinase (PRKA) anchor protein 12 -0.0416586
PTMA prothymosin, alpha -0.0414939
HILPDA hypoxia inducible lipid droplet-associated -0.0407902
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0403027
RPS8 ribosomal protein S8 -0.0397983
B2M beta-2-microglobulin -0.0396978
TAGLN2 transgelin 2 -0.0381167
NAV3 neuron navigator 3 -0.0380713
MARCKS myristoylated alanine-rich protein kinase C substrate -0.037504
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0372512
LMNA lamin A/C -0.0364485
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0363523
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0358863
TPT1 tumor protein, translationally-controlled 1 -0.0357728
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0341826
HSPB1 heat shock 27kDa protein 1 -0.033191
FTL ferritin, light polypeptide -0.0329356
RPLP1 ribosomal protein, large, P1 -0.0325776
TPI1 triosephosphate isomerase 1 -0.0324871
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0323058
CENPF centromere protein F, 350/400kDa -0.0321208
S100A10 S100 calcium binding protein A10 -0.0315145
GDF15 growth differentiation factor 15 -0.0314872
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0312843
CTTNBP2 cortactin binding protein 2 -0.0311499
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.030857
EHBP1 EH domain binding protein 1 -0.0306705
CTSD cathepsin D -0.0306226
EGR1 early growth response 1 -0.0305339
RPL35A ribosomal protein L35a -0.0296116
MT2A metallothionein 2A -0.0296085
KTN1 kinectin 1 (kinesin receptor) -0.0294477
PTCHD4 patched domain containing 4 -0.0288778
VDAC1 voltage-dependent anion channel 1 -0.0283625
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0276473
GNAS GNAS complex locus -0.027613
NPC1 Niemann-Pick disease, type C1 -0.0274772
PLIN2 perilipin 2 -0.0273501
CD44 CD44 molecule (Indian blood group) -0.0273007
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0271802
NAV1 neuron navigator 1 -0.0269827
MYO10 myosin X -0.0269086
RPL37A ribosomal protein L37a -0.0269058
MTDH metadherin -0.0267008
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0256068
TRIM2 tripartite motif containing 2 -0.0253544
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0250335
LOC102724023 ES1 protein homolog, mitochondrial -0.0249553
TM4SF1 transmembrane 4 L six family member 1 -0.0249122
COL19A1 collagen, type XIX, alpha 1 -0.0246741
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0245392
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.024163
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0238894
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0238354
MFSD12 major facilitator superfamily domain containing 12 -0.0236732
ENO2 enolase 2 (gamma, neuronal) -0.0235048
ANKRD12 ankyrin repeat domain 12 -0.0234433
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0233475
CYB5R3 cytochrome b5 reductase 3 -0.0232724
RPL34 ribosomal protein L34 -0.0231113
MT1X metallothionein 1X -0.0230715
HMGA1 high mobility group AT-hook 1 -0.0230125
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0228886
IFI16 interferon, gamma-inducible protein 16 -0.0227235
RPS19 ribosomal protein S19 -0.0225926
MYO1E myosin IE -0.0224848
ENO1 enolase 1, (alpha) -0.0222522
RPLP2 ribosomal protein, large, P2 -0.0218451
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0216572
KDM2A lysine (K)-specific demethylase 2A -0.0216099
IFITM3 interferon induced transmembrane protein 3 -0.0215604
IFI6 interferon, alpha-inducible protein 6 -0.0214485
RPL9 ribosomal protein L9 -0.02124
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0212286
DSTN destrin (actin depolymerizing factor) -0.0209885
CUX1 cut-like homeobox 1 -0.0206962
RPL30 ribosomal protein L30 -0.0205109
NEGR1 neuronal growth regulator 1 -0.0203556
PTPRD protein tyrosine phosphatase, receptor type, D -0.0202878
RNF24 ring finger protein 24 -0.0201783