Sivelestat (sodium tetrahydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.181763
SPTBN1 spectrin, beta, non-erythrocytic 1 0.136932
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.12709
NAMPT nicotinamide phosphoribosyltransferase 0.089519
TSC22D2 TSC22 domain family, member 2 0.0893871
FNDC3B fibronectin type III domain containing 3B 0.0834875
SMAD3 SMAD family member 3 0.068309
CANX calnexin 0.0677588
APP amyloid beta (A4) precursor protein 0.06048
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.059731
LOC112694756 uncharaterized LOC112694756 0.0582405
TRIO trio Rho guanine nucleotide exchange factor 0.0578728
ELL2 elongation factor, RNA polymerase II, 2 0.0568088
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0561753
FAM13A family with sequence similarity 13, member A 0.0537242
RBM39 RNA binding motif protein 39 0.0527121
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0526889
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0522924
RUNX1 runt-related transcription factor 1 0.0466714
ERRFI1 ERBB receptor feedback inhibitor 1 0.0465015
SPAG9 sperm associated antigen 9 0.0458322
HELZ helicase with zinc finger 0.0445292
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.042878
DST dystonin 0.0427188
MYH9 myosin, heavy chain 9, non-muscle 0.042532
CXCL8 chemokine (C-X-C motif) ligand 8 0.0422449
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0408789
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0407559
MYOF myoferlin 0.0406061
KDM5B lysine (K)-specific demethylase 5B 0.0401283
CCNL1 cyclin L1 0.0395481
PABPC1 poly(A) binding protein, cytoplasmic 1 0.039232
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0392193
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0370621
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.035889
ANKRD11 ankyrin repeat domain 11 0.035885
EPAS1 endothelial PAS domain protein 1 0.0352186
HOOK2 hook microtubule-tethering protein 2 0.0348417
CTNND1 catenin (cadherin-associated protein), delta 1 0.0346235
PLAU plasminogen activator, urokinase 0.0344135
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0342615
LDHA lactate dehydrogenase A 0.034172
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0341642
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0338857
PPARD peroxisome proliferator-activated receptor delta 0.0336454
MCTP1 multiple C2 domains, transmembrane 1 0.0335458
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0334905
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0331487
ARRDC3 arrestin domain containing 3 0.0330982
JMJD1C jumonji domain containing 1C 0.0329044
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0319624
EIF1 eukaryotic translation initiation factor 1 0.0317711
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0309512
KMT2E lysine (K)-specific methyltransferase 2E 0.0306869
APLP2 amyloid beta (A4) precursor-like protein 2 0.0304583
KDM3A lysine (K)-specific demethylase 3A 0.0302567
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0300979
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0300536
ADAM9 ADAM metallopeptidase domain 9 0.0299445
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0298124
DSCAM Down syndrome cell adhesion molecule 0.0297698
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0291685
EZR ezrin 0.0291073
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0288514
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0287842
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0282638
PHF3 PHD finger protein 3 0.0279133
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271752
HKDC1 hexokinase domain containing 1 0.0270445
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0266403
ZNF292 zinc finger protein 292 0.0265193
ANXA2 annexin A2 0.0265009
GCLC glutamate-cysteine ligase, catalytic subunit 0.0262479
FLNB filamin B, beta 0.026245
SQSTM1 sequestosome 1 0.0260394
OGA O-GlcNAcase 0.0259106
NPTN neuroplastin 0.0256857
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256364
SUCO SUN domain containing ossification factor 0.0256238
BRD2 bromodomain containing 2 0.0256163
TFRC transferrin receptor 0.0255094
TNIP1 TNFAIP3 interacting protein 1 0.02547
TXNRD1 thioredoxin reductase 1 0.0254021
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0252755
CCNY cyclin Y 0.0251674
TUFT1 tuftelin 1 0.0251319
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.025027
SRP54 signal recognition particle 54kDa 0.0244268
STC2 stanniocalcin 2 0.024409
MYO1B myosin IB 0.024367
TTC3 tetratricopeptide repeat domain 3 0.0243065
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0243006
TGM2 transglutaminase 2 0.0242622
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0241928
YEATS2 YEATS domain containing 2 0.024133
EREG epiregulin 0.0241076
FTH1 ferritin, heavy polypeptide 1 0.0240466
TRA2A transformer 2 alpha homolog (Drosophila) 0.0239665
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0237735
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0237711

decreased expression

Symbol Name Standardized Value
MMP7 matrix metallopeptidase 7 -0.168463
CP ceruloplasmin (ferroxidase) -0.122005
IFI27 interferon, alpha-inducible protein 27 -0.117969
TMSB10 thymosin beta 10 -0.116992
KRT19 keratin 19, type I -0.103917
B2M beta-2-microglobulin -0.0926116
LAMB3 laminin, beta 3 -0.0899814
TPT1 tumor protein, translationally-controlled 1 -0.0889146
MT2A metallothionein 2A -0.0856826
APOL1 apolipoprotein L, 1 -0.0851345
PTMA prothymosin, alpha -0.0819563
S100A6 S100 calcium binding protein A6 -0.081694
HLA-B major histocompatibility complex, class I, B -0.0794591
TM4SF1 transmembrane 4 L six family member 1 -0.0592193
PLAT plasminogen activator, tissue -0.0574572
ISG15 ISG15 ubiquitin-like modifier -0.0548436
TMSB4X thymosin beta 4, X-linked -0.0525341
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0514434
LCN2 lipocalin 2 -0.0513733
CNRIP1 cannabinoid receptor interacting protein 1 -0.049257
CSTB cystatin B (stefin B) -0.0480444
LAMC2 laminin, gamma 2 -0.0479017
LAMA4 laminin, alpha 4 -0.0468857
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.04677
RPL35A ribosomal protein L35a -0.0465159
IFI6 interferon, alpha-inducible protein 6 -0.0440925
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0428034
C15ORF48 chromosome 15 open reading frame 48 -0.0417862
RPS8 ribosomal protein S8 -0.0415808
ITGA6 integrin, alpha 6 -0.0387406
VIM vimentin -0.0374741
SACK1A scaffolding CK1 anchoring protein A -0.0363247
LY6E lymphocyte antigen 6 complex, locus E -0.0351644
RPL9 ribosomal protein L9 -0.0348504
EFNA5 ephrin-A5 -0.0337559
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0334353
RPS24 ribosomal protein S24 -0.0329765
EGR1 early growth response 1 -0.031906
IGFBP3 insulin-like growth factor binding protein 3 -0.0315507
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0306465
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.030438
RPS21 ribosomal protein S21 -0.0303743
RPL37A ribosomal protein L37a -0.0303248
RPLP1 ribosomal protein, large, P1 -0.0295042
RPL34 ribosomal protein L34 -0.0292207
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0290972
SLC38A1 solute carrier family 38, member 1 -0.0281414
RPS19 ribosomal protein S19 -0.0278636
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0274597
S100A10 S100 calcium binding protein A10 -0.0272691
PARD3 par-3 family cell polarity regulator -0.0268115
NPEPPS aminopeptidase puromycin sensitive -0.0265148
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0255377
RPL19 ribosomal protein L19 -0.0255135
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0253626
RPL23 ribosomal protein L23 -0.02489
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0248275
ANTXR2 anthrax toxin receptor 2 -0.0247518
RPS6 ribosomal protein S6 -0.0245629
RPS25 ribosomal protein S25 -0.0245233
ANXA4 annexin A4 -0.0243334
MAML2 mastermind-like 2 (Drosophila) -0.0239538
LMO7 LIM domain 7 -0.0239089
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0238806
IFITM1 interferon induced transmembrane protein 1 -0.0237958
S100A11 S100 calcium binding protein A11 -0.0236244
HMGA2 high mobility group AT-hook 2 -0.0235789
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0232761
MDK midkine (neurite growth-promoting factor 2) -0.0229856
IFITM3 interferon induced transmembrane protein 3 -0.0226757
HMGA1 high mobility group AT-hook 1 -0.0226665
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0224677
ZMYND8 zinc finger, MYND-type containing 8 -0.022363
S100P S100 calcium binding protein P -0.0222778
RPLP2 ribosomal protein, large, P2 -0.0219055
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0218376
TPM4 tropomyosin 4 -0.0217843
MX2 MX dynamin-like GTPase 2 -0.0217487
C3 complement component 3 -0.0213205
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0209817
RPL11 ribosomal protein L11 -0.020553
MUC1 mucin 1, cell surface associated -0.0203736
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0202712
CD63 CD63 molecule -0.0200504
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0199966
GCC2 GRIP and coiled-coil domain containing 2 -0.0199881
NT5C2 5'-nucleotidase, cytosolic II -0.0198294
KRT18 keratin 18, type I -0.0195895
NPAS2 neuronal PAS domain protein 2 -0.0195074
PERP PERP, TP53 apoptosis effector -0.0194904
RPL12 ribosomal protein L12 -0.019398
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0193591
PMP22 peripheral myelin protein 22 -0.0193459
RPS29 ribosomal protein S29 -0.0189928
RPS27 ribosomal protein S27 -0.0189822
FERMT1 fermitin family member 1 -0.0188699
RPL26 ribosomal protein L26 -0.0187692
CYBA cytochrome b-245, alpha polypeptide -0.0186931
DSG2 desmoglein 2 -0.0184122
RPL37 ribosomal protein L37 -0.0183148