Sivelestat (sodium tetrahydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.151333
LSAMP limbic system-associated membrane protein 0.114583
NRG1 neuregulin 1 0.104549
VCL vinculin 0.0904372
NALF1 NALCN channel auxiliary factor 1 0.0878661
PTPRD protein tyrosine phosphatase, receptor type, D 0.0749161
MEIS2 Meis homeobox 2 0.0689415
PRKCA protein kinase C, alpha 0.0608803
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0571392
LINGO2 leucine rich repeat and Ig domain containing 2 0.0555499
EXT1 exostosin glycosyltransferase 1 0.0555292
TLE4 transducin-like enhancer of split 4 0.0553008
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.053492
VMP1 vacuole membrane protein 1 0.0516699
ANTXR1 anthrax toxin receptor 1 0.0510897
ZSWIM6 zinc finger, SWIM-type containing 6 0.0502236
FNDC3B fibronectin type III domain containing 3B 0.0425688
MSI2 musashi RNA-binding protein 2 0.0425044
RAD51B RAD51 paralog B 0.0422063
LIMCH1 LIM and calponin homology domains 1 0.0421631
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.040622
FRMD4A FERM domain containing 4A 0.0401707
SOS1 son of sevenless homolog 1 (Drosophila) 0.0384694
UNC5C unc-5 homolog C (C. elegans) 0.038439
CPED1 cadherin-like and PC-esterase domain containing 1 0.0384001
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0373177
PSD3 pleckstrin and Sec7 domain containing 3 0.0364437
PBX1 pre-B-cell leukemia homeobox 1 0.0364291
SYT1 synaptotagmin I 0.0362791
ITPRID2 ITPR interacting domain containing 2 0.0362162
PLAT plasminogen activator, tissue 0.0346924
AHR aryl hydrocarbon receptor 0.0346512
PDZRN3 PDZ domain containing ring finger 3 0.0342187
MBD5 methyl-CpG binding domain protein 5 0.0339138
HELZ helicase with zinc finger 0.0326858
BCAS3 breast carcinoma amplified sequence 3 0.0326079
ZBTB20 zinc finger and BTB domain containing 20 0.0323846
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0322966
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0316914
THSD4 thrombospondin, type I, domain containing 4 0.031533
SMYD3 SET and MYND domain containing 3 0.0309144
TPST1 tyrosylprotein sulfotransferase 1 0.030705
KLHL13 kelch-like family member 13 0.0306456
SLITRK6 SLIT and NTRK-like family, member 6 0.030622
ADARB1 adenosine deaminase, RNA-specific, B1 0.0303373
NCAM2 neural cell adhesion molecule 2 0.0298945
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0293306
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0285896
EXOC4 exocyst complex component 4 0.0279603
CADM2 cell adhesion molecule 2 0.0277988
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0277629
TCF12 transcription factor 12 0.0276954
COL4A2 collagen, type IV, alpha 2 0.0272502
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0270733
MBNL2 muscleblind-like splicing regulator 2 0.0268421
NREP neuronal regeneration related protein 0.0268013
GLCCI1 glucocorticoid induced 1 0.0266791
LPP LIM domain containing preferred translocation partner in lipoma 0.0265427
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0259991
AUTS2 autism susceptibility candidate 2 0.0259653
PTPRM protein tyrosine phosphatase, receptor type, M 0.0259537
DST dystonin 0.0258195
KCNIP4 Kv channel interacting protein 4 0.0256841
PACS1 phosphofurin acidic cluster sorting protein 1 0.0254775
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0254759
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0254015
ADGRB3 adhesion G protein-coupled receptor B3 0.0253535
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0252746
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0251577
GREM2 gremlin 2, DAN family BMP antagonist 0.0246182
MAPK10 mitogen-activated protein kinase 10 0.0242207
FERMT2 fermitin family member 2 0.0241545
TRPS1 trichorhinophalangeal syndrome I 0.0236061
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0233758
FNDC3A fibronectin type III domain containing 3A 0.0231554
SEPTIN9 septin 9 0.023025
FAM13B family with sequence similarity 13, member B 0.0229303
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0227558
COL4A5 collagen, type IV, alpha 5 0.0226797
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0226156
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0225071
TENM4 teneurin transmembrane protein 4 0.0224523
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0222548
TAS2R14 taste receptor, type 2, member 14 0.0216738
MBTD1 mbt domain containing 1 0.0214704
PUM2 pumilio RNA-binding family member 2 0.0213004
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.021237
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.021047
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0209379
PTPRG protein tyrosine phosphatase, receptor type, G 0.0207796
DPH6 diphthamine biosynthesis 6 0.0206653
MYH9 myosin, heavy chain 9, non-muscle 0.0206245
RAB30 RAB30, member RAS oncogene family 0.0202531
PTPRK protein tyrosine phosphatase, receptor type, K 0.0201834
FTO fat mass and obesity associated 0.0201536
PEAK1 pseudopodium-enriched atypical kinase 1 0.0199223
CHD9 chromodomain helicase DNA binding protein 9 0.0198452
IGFBP5 insulin-like growth factor binding protein 5 0.0198432
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0197842
ATRNL1 attractin-like 1 0.0197804

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.0964555
ACTG1 actin gamma 1 -0.0938854
PTMA prothymosin, alpha -0.0926013
VIM vimentin -0.0922906
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.091857
IGF2 insulin-like growth factor 2 -0.0897938
TPT1 tumor protein, translationally-controlled 1 -0.0655511
RPL35A ribosomal protein L35a -0.0641635
RPS8 ribosomal protein S8 -0.0581285
RPS24 ribosomal protein S24 -0.0566906
RPL34 ribosomal protein L34 -0.0564839
RPL11 ribosomal protein L11 -0.0553129
TMSB10 thymosin beta 10 -0.047976
RPLP1 ribosomal protein, large, P1 -0.0478718
RPL38 ribosomal protein L38 -0.0461245
RPS25 ribosomal protein S25 -0.0457568
RPL19 ribosomal protein L19 -0.0439227
RPLP0 ribosomal protein, large, P0 -0.0429346
NDRG1 N-myc downstream regulated 1 -0.0428765
IER3 immediate early response 3 -0.0415816
RPL23 ribosomal protein L23 -0.0414961
RPL12 ribosomal protein L12 -0.0382934
S100A6 S100 calcium binding protein A6 -0.0377443
RPS19 ribosomal protein S19 -0.0369078
RPS16 ribosomal protein S16 -0.0368585
B2M beta-2-microglobulin -0.0364596
EIF1 eukaryotic translation initiation factor 1 -0.0364131
RPL26 ribosomal protein L26 -0.0352857
FTL ferritin, light polypeptide -0.0347958
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0346742
RPL28 ribosomal protein L28 -0.0338262
RPS12 ribosomal protein S12 -0.033824
RPS27 ribosomal protein S27 -0.0335335
RPS29 ribosomal protein S29 -0.0329816
RPS27A ribosomal protein S27a -0.0326708
RPL36A ribosomal protein L36a -0.0310992
RPL32 ribosomal protein L32 -0.0304665
RPS14 ribosomal protein S14 -0.0302003
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029356
ENO1 enolase 1, (alpha) -0.0288988
RPL7A ribosomal protein L7a -0.0288586
RPL9 ribosomal protein L9 -0.0287753
TM4SF1 transmembrane 4 L six family member 1 -0.028462
RPS3 ribosomal protein S3 -0.0280153
S100A10 S100 calcium binding protein A10 -0.0277663
RPL31 ribosomal protein L31 -0.027717
RPS13 ribosomal protein S13 -0.0266715
MT2A metallothionein 2A -0.0265868
RPS23 ribosomal protein S23 -0.0261734
AKAP12 A kinase (PRKA) anchor protein 12 -0.0259434
NAP1L1 nucleosome assembly protein 1-like 1 -0.0258192
PDE4D phosphodiesterase 4D, cAMP-specific -0.0247594
RPL30 ribosomal protein L30 -0.0246016
RACK1 receptor for activated C kinase 1 -0.0244512
LOC102724023 ES1 protein homolog, mitochondrial -0.0244455
RPL37A ribosomal protein L37a -0.0244188
RPL13A ribosomal protein L13a -0.0243656
RPS21 ribosomal protein S21 -0.0243344
RPS11 ribosomal protein S11 -0.0242991
FTH1 ferritin, heavy polypeptide 1 -0.0239315
ACBD3 acyl-CoA binding domain containing 3 -0.0237777
RPS10 ribosomal protein S10 -0.0237126
RPLP2 ribosomal protein, large, P2 -0.0236121
RTN4 reticulon 4 -0.0234009
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0233449
ANXA2 annexin A2 -0.023251
GDF15 growth differentiation factor 15 -0.0232452
GCC2 GRIP and coiled-coil domain containing 2 -0.0231829
HMGA1 high mobility group AT-hook 1 -0.0226918
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0225634
RPS5 ribosomal protein S5 -0.0222543
RPS17 ribosomal protein S17 -0.0219275
RPS15 ribosomal protein S15 -0.0215247
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0212745
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0212217
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0206024
PHIP pleckstrin homology domain interacting protein -0.0203496
HMGB1 high mobility group box 1 -0.0202394
WSB1 WD repeat and SOCS box containing 1 -0.0200433
KIAA1217 KIAA1217 -0.0199479
RPL37 ribosomal protein L37 -0.0198022
HLA-B major histocompatibility complex, class I, B -0.0197154
MTDH metadherin -0.0195635
RPL36 ribosomal protein L36 -0.0194916
CEMIP cell migration inducing protein, hyaluronan binding -0.019398
RPS20 ribosomal protein S20 -0.0193919
EFNA5 ephrin-A5 -0.0193805
DDIT4 DNA-damage-inducible transcript 4 -0.0193519
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0193336
EIF5B eukaryotic translation initiation factor 5B -0.0190387
KPNB1 karyopherin (importin) beta 1 -0.018987
NACA nascent polypeptide-associated complex alpha subunit -0.0189714
VDAC1 voltage-dependent anion channel 1 -0.0188497
GNAS GNAS complex locus -0.0188296
LMNA lamin A/C -0.0187401
ZNFX1 zinc finger, NFX1-type containing 1 -0.0186712
POTEF POTE ankyrin domain family, member F -0.0181386
SRP72 signal recognition particle 72kDa -0.0179811
STC1 stanniocalcin 1 -0.0179308
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0179191