| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.183914 |
| COL6A3 | collagen, type VI, alpha 3 | 0.124845 |
| FNDC3B | fibronectin type III domain containing 3B | 0.107557 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0975653 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.086795 |
| CANX | calnexin | 0.0845617 |
| NDRG1 | N-myc downstream regulated 1 | 0.0836589 |
| LDHA | lactate dehydrogenase A | 0.0824249 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0596997 |
| FAM13A | family with sequence similarity 13, member A | 0.0579226 |
| HELZ | helicase with zinc finger | 0.0562151 |
| SMAD3 | SMAD family member 3 | 0.0560072 |
| EGFR | epidermal growth factor receptor | 0.0546038 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0515165 |
| CADM1 | cell adhesion molecule 1 | 0.0508642 |
| AHNAK | AHNAK nucleoprotein | 0.0506338 |
| PKM | pyruvate kinase, muscle | 0.0466051 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0453906 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0447128 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0427021 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0409747 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0404007 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0398149 |
| HDLBP | high density lipoprotein binding protein | 0.0388944 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0387881 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0386497 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.037427 |
| ATXN1 | ataxin 1 | 0.0352334 |
| COPA | coatomer protein complex, subunit alpha | 0.0351689 |
| SUCO | SUN domain containing ossification factor | 0.0349241 |
| NAV2 | neuron navigator 2 | 0.0347532 |
| CALR | calreticulin | 0.0346461 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0344163 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0344154 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0342559 |
| ATP13A3 | ATPase type 13A3 | 0.0341907 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0334658 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.033007 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0329473 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0326941 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0325819 |
| MYOF | myoferlin | 0.032335 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0323309 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0322534 |
| YEATS2 | YEATS domain containing 2 | 0.0322144 |
| COL5A1 | collagen, type V, alpha 1 | 0.0321098 |
| CLTC | clathrin, heavy chain (Hc) | 0.0320437 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0314841 |
| GRB10 | growth factor receptor-bound protein 10 | 0.031429 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0313934 |
| OGA | O-GlcNAcase | 0.0309649 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0308937 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0307592 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0306416 |
| HYOU1 | hypoxia up-regulated 1 | 0.0297669 |
| ANKRD17 | ankyrin repeat domain 17 | 0.029755 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0292876 |
| CALN1 | calneuron 1 | 0.0291233 |
| MYO1B | myosin IB | 0.0290275 |
| TXNRD1 | thioredoxin reductase 1 | 0.0288211 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0287479 |
| ZNF395 | zinc finger protein 395 | 0.0287322 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.028609 |
| ZNF841 | zinc finger protein 841 | 0.0285828 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0283749 |
| RTN4 | reticulon 4 | 0.0283618 |
| FLNB | filamin B, beta | 0.0282711 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0282339 |
| MEF2A | myocyte enhancer factor 2A | 0.0281732 |
| ZNF292 | zinc finger protein 292 | 0.0281255 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0281248 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.028111 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0280641 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0280287 |
| TFG | TRK-fused gene | 0.0278219 |
| PCBP3 | poly(rC) binding protein 3 | 0.0273391 |
| DST | dystonin | 0.0273115 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0269452 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0269176 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0268008 |
| FAM219A | family with sequence similarity 219, member A | 0.0267164 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0266904 |
| SNX13 | sorting nexin 13 | 0.0261299 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0260931 |
| LOXL2 | lysyl oxidase-like 2 | 0.0260699 |
| PRELID2 | PRELI domain containing 2 | 0.0260444 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0260183 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0259943 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0259321 |
| SEPTIN9 | septin 9 | 0.0257999 |
| FNIP1 | folliculin interacting protein 1 | 0.0253385 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0252881 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0251165 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0251127 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0248765 |
| SEC24D | SEC24 family member D | 0.0248627 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0248543 |
| ANK2 | ankyrin 2, neuronal | 0.024823 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0247496 |
| NBAS | neuroblastoma amplified sequence | 0.0244042 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.184125 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.127486 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.124257 |
| TMSB10 | thymosin beta 10 | -0.118354 |
| MT2A | metallothionein 2A | -0.110207 |
| B2M | beta-2-microglobulin | -0.0652366 |
| HLA-B | major histocompatibility complex, class I, B | -0.0633292 |
| FN1 | fibronectin 1 | -0.0599242 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0598762 |
| RPS8 | ribosomal protein S8 | -0.0551563 |
| RPL35A | ribosomal protein L35a | -0.0523051 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0484067 |
| PTMA | prothymosin, alpha | -0.0435953 |
| PRSS23 | protease, serine, 23 | -0.0421971 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0420297 |
| FTL | ferritin, light polypeptide | -0.0416674 |
| RPLP2 | ribosomal protein, large, P2 | -0.0402007 |
| TPM4 | tropomyosin 4 | -0.0401959 |
| RPL34 | ribosomal protein L34 | -0.0401923 |
| S100A6 | S100 calcium binding protein A6 | -0.0397323 |
| CD44 | CD44 molecule (Indian blood group) | -0.0388346 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0375127 |
| CALD1 | caldesmon 1 | -0.0362925 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0355994 |
| RPL37A | ribosomal protein L37a | -0.0355597 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0354889 |
| CLMP | CXADR-like membrane protein | -0.0331235 |
| RPS6 | ribosomal protein S6 | -0.0328041 |
| RPS13 | ribosomal protein S13 | -0.0326046 |
| S100A9 | S100 calcium binding protein A9 | -0.0321734 |
| RPL9 | ribosomal protein L9 | -0.0319222 |
| IGF2 | insulin-like growth factor 2 | -0.0298012 |
| S100A10 | S100 calcium binding protein A10 | -0.0297273 |
| RPLP1 | ribosomal protein, large, P1 | -0.0295625 |
| SEC61G | Sec61 gamma subunit | -0.0283559 |
| ACTG1 | actin gamma 1 | -0.0281563 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0280165 |
| RPS19 | ribosomal protein S19 | -0.0276719 |
| RPS24 | ribosomal protein S24 | -0.0276019 |
| RPS21 | ribosomal protein S21 | -0.0257307 |
| RPL23 | ribosomal protein L23 | -0.0253829 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0247497 |
| HLA-A | major histocompatibility complex, class I, A | -0.0243463 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0240304 |
| TMSB4X | thymosin beta 4, X-linked | -0.0234093 |
| RPL12 | ribosomal protein L12 | -0.0228276 |
| CCND1 | cyclin D1 | -0.0228191 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0226407 |
| MT1X | metallothionein 1X | -0.0225087 |
| CBX3 | chromobox homolog 3 | -0.0221804 |
| HMGA1 | high mobility group AT-hook 1 | -0.0220696 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0220556 |
| RPS29 | ribosomal protein S29 | -0.0217871 |
| RPS27A | ribosomal protein S27a | -0.0216787 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0215253 |
| RPL19 | ribosomal protein L19 | -0.0212619 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0206473 |
| RPS14 | ribosomal protein S14 | -0.0201711 |
| RPLP0 | ribosomal protein, large, P0 | -0.0200853 |
| RPL28 | ribosomal protein L28 | -0.0197987 |
| STC1 | stanniocalcin 1 | -0.0197074 |
| SEPTIN7 | septin 7 | -0.0197032 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0196798 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0195585 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0194232 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0193288 |
| HLA-C | major histocompatibility complex, class I, C | -0.0190208 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0188691 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0185921 |
| RPS12 | ribosomal protein S12 | -0.0185346 |
| RPL7A | ribosomal protein L7a | -0.0185008 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0184493 |
| H3-3B | H3.3 histone B | -0.0182768 |
| ASTN2 | astrotactin 2 | -0.0182751 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.017965 |
| RPS11 | ribosomal protein S11 | -0.0179294 |
| RPL11 | ribosomal protein L11 | -0.0179188 |
| CDK14 | cyclin-dependent kinase 14 | -0.0178923 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0178298 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0178217 |
| PXDN | peroxidasin | -0.0177501 |
| DEK | DEK proto-oncogene | -0.0177452 |
| MRC2 | mannose receptor, C type 2 | -0.017332 |
| HMGB1 | high mobility group box 1 | -0.0171789 |
| NAV3 | neuron navigator 3 | -0.0169176 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0168529 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0168207 |
| RPS20 | ribosomal protein S20 | -0.0168041 |
| RPS17 | ribosomal protein S17 | -0.0166927 |
| ASPH | aspartate beta-hydroxylase | -0.0166848 |
| MYLK | myosin light chain kinase | -0.016475 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0164697 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.016423 |
| RPL8 | ribosomal protein L8 | -0.0164142 |
| LMNA | lamin A/C | -0.0163726 |
| RPL31 | ribosomal protein L31 | -0.0162228 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0160127 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0157231 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0155953 |
| RPL7 | ribosomal protein L7 | -0.0155757 |
