Sivelestat (sodium tetrahydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.195424
AHNAK AHNAK nucleoprotein 0.124963
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.098111
DSCAM Down syndrome cell adhesion molecule 0.0887967
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0859997
MED13L mediator complex subunit 13-like 0.0717817
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0696522
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0649266
CANX calnexin 0.0620641
LDHA lactate dehydrogenase A 0.0599514
CTNND1 catenin (cadherin-associated protein), delta 1 0.0568511
PRELID2 PRELI domain containing 2 0.0560514
EZR ezrin 0.0521123
JMJD1C jumonji domain containing 1C 0.0504822
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0494475
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.047618
FNDC3B fibronectin type III domain containing 3B 0.046027
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0458376
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0453106
ENO1 enolase 1, (alpha) 0.0446844
TXNRD1 thioredoxin reductase 1 0.0438993
PGK1 phosphoglycerate kinase 1 0.0421162
CD2AP CD2-associated protein 0.0420703
RAD51B RAD51 paralog B 0.0419874
ZFAND3 zinc finger, AN1-type domain 3 0.0415731
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0415462
BIRC6 baculoviral IAP repeat containing 6 0.0415186
ZNF292 zinc finger protein 292 0.0405956
HDLBP high density lipoprotein binding protein 0.0392197
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0385904
SEC31A SEC31 homolog A (S. cerevisiae) 0.038571
CTBP2 C-terminal binding protein 2 0.0379258
EIF4B eukaryotic translation initiation factor 4B 0.0376932
TENM3 teneurin transmembrane protein 3 0.0372837
LOC112694756 uncharaterized LOC112694756 0.0372508
MYH9 myosin, heavy chain 9, non-muscle 0.0371641
RBM39 RNA binding motif protein 39 0.0370232
EEF2 eukaryotic translation elongation factor 2 0.036544
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0365273
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0365093
KDM4C lysine (K)-specific demethylase 4C 0.0363618
NF1 neurofibromin 1 0.0359075
PCBP2 poly(rC) binding protein 2 0.03522
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0350475
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0349519
TCF12 transcription factor 12 0.0344466
PRRC2B proline-rich coiled-coil 2B 0.0343616
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0339164
KRT8 keratin 8, type II 0.0332145
MBD5 methyl-CpG binding domain protein 5 0.0329086
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0328707
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0326336
PATJ PATJ crumbs cell polarity complex component 0.0324147
TAS2R14 taste receptor, type 2, member 14 0.0322361
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0320141
PUM2 pumilio RNA-binding family member 2 0.0314283
MSI2 musashi RNA-binding protein 2 0.0307437
LCORL ligand dependent nuclear receptor corepressor-like 0.0306124
PDIA3 protein disulfide isomerase family A, member 3 0.0303745
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0302468
RAB1A RAB1A, member RAS oncogene family 0.0299023
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0298366
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0296427
MON2 MON2 homolog (S. cerevisiae) 0.0293949
MBNL2 muscleblind-like splicing regulator 2 0.029365
EXOC4 exocyst complex component 4 0.0291975
GANAB glucosidase, alpha; neutral AB 0.0291656
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0288939
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0287315
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0287199
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0286556
LMAN1 lectin, mannose-binding, 1 0.0286058
WAC WW domain containing adaptor with coiled-coil 0.0279158
FAM117B family with sequence similarity 117, member B 0.0278521
FTH1 ferritin, heavy polypeptide 1 0.02779
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.027706
TBC1D22A TBC1 domain family, member 22A 0.0277024
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0274041
ACTN4 actinin, alpha 4 0.0271572
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0270953
WDR26 WD repeat domain 26 0.0269062
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0264887
FUS FUS RNA binding protein 0.0263987
LSR lipolysis stimulated lipoprotein receptor 0.0263483
SPTBN1 spectrin, beta, non-erythrocytic 1 0.026341
SPRED2 sprouty-related, EVH1 domain containing 2 0.0262039
SFPQ splicing factor proline/glutamine-rich 0.0259499
TMEM263 transmembrane protein 263 0.0259447
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0258831
HOOK2 hook microtubule-tethering protein 2 0.025713
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0256392
ARHGAP5 Rho GTPase activating protein 5 0.0254262
SHROOM3 shroom family member 3 0.0254059
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0253145
CSDE1 cold shock domain containing E1, RNA-binding 0.0252817
LPP LIM domain containing preferred translocation partner in lipoma 0.0248469
RAD21 RAD21 homolog (S. pombe) 0.0247744
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0246917
CALR calreticulin 0.0244376
HMBOX1 homeobox containing 1 0.0241942

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0688448
MT2A metallothionein 2A -0.0683989
RPS3 ribosomal protein S3 -0.0650588
TMSB10 thymosin beta 10 -0.0648246
RPS6 ribosomal protein S6 -0.064006
RPS8 ribosomal protein S8 -0.0564456
FTL ferritin, light polypeptide -0.0562602
TPT1 tumor protein, translationally-controlled 1 -0.0541978
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0534624
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0522356
RPS2 ribosomal protein S2 -0.0500339
RPL37A ribosomal protein L37a -0.045881
RPS12 ribosomal protein S12 -0.0451058
PTMA prothymosin, alpha -0.044723
RPL26 ribosomal protein L26 -0.0402018
RPLP2 ribosomal protein, large, P2 -0.0383102
RPL35A ribosomal protein L35a -0.0375789
INTS6 integrator complex subunit 6 -0.0375158
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0368754
RPL7A ribosomal protein L7a -0.0356805
RPL19 ribosomal protein L19 -0.0327281
RPS27A ribosomal protein S27a -0.0326483
RPL18 ribosomal protein L18 -0.0319205
RPLP1 ribosomal protein, large, P1 -0.0316707
RPL31 ribosomal protein L31 -0.0295186
RPS25 ribosomal protein S25 -0.0290895
SET SET nuclear proto-oncogene -0.0290035
RPL36 ribosomal protein L36 -0.0287963
RPS19 ribosomal protein S19 -0.0280793
RPL7 ribosomal protein L7 -0.0278425
RPL11 ribosomal protein L11 -0.0256936
RPS29 ribosomal protein S29 -0.0256405
PRRC2C proline-rich coiled-coil 2C -0.0253656
NAP1L1 nucleosome assembly protein 1-like 1 -0.0244134
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0241566
RPL12 ribosomal protein L12 -0.0236517
TPI1 triosephosphate isomerase 1 -0.0235854
RPS13 ribosomal protein S13 -0.0234968
RPS17 ribosomal protein S17 -0.0233906
KTN1 kinectin 1 (kinesin receptor) -0.0223511
TUBB4B tubulin, beta 4B class IVb -0.0222257
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0221693
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0221385
RPS16 ribosomal protein S16 -0.0208708
RPL32 ribosomal protein L32 -0.0207105
RPS14 ribosomal protein S14 -0.0206826
RPL34 ribosomal protein L34 -0.0205027
EIF1 eukaryotic translation initiation factor 1 -0.0202597
LRRC23 leucine rich repeat containing 23 -0.0200408
RPL36A ribosomal protein L36a -0.0199615
RPL35 ribosomal protein L35 -0.0197115
ACTG1 actin gamma 1 -0.0194818
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0189849
RPL9 ribosomal protein L9 -0.018168
RPS10 ribosomal protein S10 -0.0181425
RPL23 ribosomal protein L23 -0.0179413
S100A10 S100 calcium binding protein A10 -0.0173141
RPS5 ribosomal protein S5 -0.0171426
SNX14 sorting nexin 14 -0.0171163
RPL21 ribosomal protein L21 -0.0171087
RPS27 ribosomal protein S27 -0.0170153
RUNX1 runt-related transcription factor 1 -0.0168852
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0168836
IFITM3 interferon induced transmembrane protein 3 -0.016729
PFN1 profilin 1 -0.0165379
RPL28 ribosomal protein L28 -0.0163306
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0161658
TLN1 talin 1 -0.015811
RACK1 receptor for activated C kinase 1 -0.0155738
GPC5 glypican 5 -0.015443
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0151774
RPL37 ribosomal protein L37 -0.0151478
ATF4 activating transcription factor 4 -0.0151051
DDIT4 DNA-damage-inducible transcript 4 -0.0150936
SERF2 small EDRK-rich factor 2 -0.014919
FAM107B family with sequence similarity 107, member B -0.0147971
PABPN1 poly(A) binding protein, nuclear 1 -0.0147302
RPL8 ribosomal protein L8 -0.0145335
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0144318
S100A9 S100 calcium binding protein A9 -0.0144218
LDHB lactate dehydrogenase B -0.0144193
RPL15 ribosomal protein L15 -0.0141583
RPL10A ribosomal protein L10a -0.0138165
RPL5 ribosomal protein L5 -0.0137622
H1-4 H1.4 linker histone, cluster member -0.0136962
SEC61G Sec61 gamma subunit -0.0136756
NIPSNAP2 nipsnap homolog 2 -0.0134006
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0131358
RNF24 ring finger protein 24 -0.0131263
NDRG1 N-myc downstream regulated 1 -0.0128685
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.012827
RPS23 ribosomal protein S23 -0.0126967
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0126378
RPL27 ribosomal protein L27 -0.0125549
TGFB1 transforming growth factor, beta 1 -0.0125247
TMF1 TATA element modulatory factor 1 -0.0124134
AGO3 argonaute RISC catalytic component 3 -0.0124003
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0123557
RPS15 ribosomal protein S15 -0.0123219
NACA nascent polypeptide-associated complex alpha subunit -0.0122812